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    Pwwp3b PWWP domain containing 3B [ Mus musculus (house mouse) ]

    Gene ID: 245631, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pwwp3bprovided by MGI
    Official Full Name
    PWWP domain containing 3Bprovided by MGI
    Primary source
    MGI:MGI:2445062
    See related
    Ensembl:ENSMUSG00000042515 AllianceGenome:MGI:2445062
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mum1l1; 9430086K21Rik
    Summary
    Is expressed in heart; lateral ventricle choroid plexus; metencephalon part of 4th ventricle choroid plexus; tongue muscle; and vertebral axis musculature. Orthologous to human PWWP3B (PWWP domain containing 3B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in limb E14.5 (RPKM 4.6), placenta adult (RPKM 3.8) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pwwp3b in Genome Data Viewer
    Location:
    X F1; X 61.29 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (138110726..138139084)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (139209977..139238335)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 pseudogene Neighboring gene RIKEN cDNA 4933428M09 gene Neighboring gene pluripotency associated transcript 21 Neighboring gene STARR-seq mESC enhancer starr_47991 Neighboring gene tumor rejection antigen P1A Neighboring gene STARR-seq mESC enhancer starr_47993 Neighboring gene transcription elongation factor B (SIII), polypeptide 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Endocardiogenesis in embryoid bodies: novel markers identified by gene expression profiling. Narumiya H, et al. Biochem Biophys Res Commun, 2007 Jun 15. PMID 17462595
    2. Quantitative Proteomic Analysis Reveals apoE4-Dependent Phosphorylation of the Actin-Regulating Protein VASP. Cakir Z, et al. Mol Cell Proteomics, 2023 May. PMID 37019383, Free PMC Article
    3. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    PWWP domain-containing DNA repair factor 3B
    Names
    MUM1-like protein 1
    PWWP domain-containing protein MUM1L1
    melanoma associated antigen (mutated) 1-like 1
    mutated melanoma-associated antigen 1-like protein 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164630.1 → NP_001158102.1  PWWP domain-containing DNA repair factor 3B

      See identical proteins and their annotated locations for NP_001158102.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, 4, and 5 encode the same protein
      Source sequence(s)
      AL732419, BC068178, BY713797
      Consensus CDS
      CCDS30432.2
      UniProtKB/Swiss-Prot
      B1AW67, Q0VBL8, Q4VA55, Q7TSI2, Q8BS63
      UniProtKB/TrEMBL
      B2RPZ1
      Related
      ENSMUSP00000108666.2, ENSMUST00000113043.8
      Conserved Domains (1) summary
      cd06080
      Location:375 → 454
      MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...

    2. NM_001164631.1 → NP_001158103.1  PWWP domain-containing DNA repair factor 3B

      See identical proteins and their annotated locations for NP_001158103.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
      Source sequence(s)
      AL732419, BC068178, CN695260
      Consensus CDS
      CCDS30432.2
      UniProtKB/Swiss-Prot
      B1AW67, Q0VBL8, Q4VA55, Q7TSI2, Q8BS63
      UniProtKB/TrEMBL
      B2RPZ1
      Related
      ENSMUSP00000108665.3, ENSMUST00000113042.3
      Conserved Domains (1) summary
      cd06080
      Location:375 → 454
      MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...

    3. NM_001164632.1 → NP_001158104.1  PWWP domain-containing DNA repair factor 3B

      See identical proteins and their annotated locations for NP_001158104.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
      Source sequence(s)
      AL732419, BC068178, BY124815, CD351791
      Consensus CDS
      CCDS30432.2
      UniProtKB/Swiss-Prot
      B1AW67, Q0VBL8, Q4VA55, Q7TSI2, Q8BS63
      UniProtKB/TrEMBL
      B2RPZ1
      Related
      ENSMUSP00000108664.3, ENSMUST00000113041.9
      Conserved Domains (1) summary
      cd06080
      Location:375 → 454
      MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...

    4. NM_001164633.1 → NP_001158105.1  PWWP domain-containing DNA repair factor 3B

      See identical proteins and their annotated locations for NP_001158105.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
      Source sequence(s)
      AL732419
      Consensus CDS
      CCDS30432.2
      UniProtKB/Swiss-Prot
      B1AW67, Q0VBL8, Q4VA55, Q7TSI2, Q8BS63
      UniProtKB/TrEMBL
      B2RPZ1
      Conserved Domains (1) summary
      cd06080
      Location:375 → 454
      MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...

    5. NM_175541.3 → NP_780750.2  PWWP domain-containing DNA repair factor 3B

      See identical proteins and their annotated locations for NP_780750.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
      Source sequence(s)
      AL732419, BC068178, BY729100
      Consensus CDS
      CCDS30432.2
      UniProtKB/Swiss-Prot
      B1AW67, Q0VBL8, Q4VA55, Q7TSI2, Q8BS63
      UniProtKB/TrEMBL
      B2RPZ1
      Related
      ENSMUSP00000108668.3, ENSMUST00000113045.9
      Conserved Domains (1) summary
      cd06080
      Location:375 → 454
      MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      138110726..138139084
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528544.2 → XP_006528607.1  PWWP domain-containing DNA repair factor 3B isoform X1

      See identical proteins and their annotated locations for XP_006528607.1

      UniProtKB/Swiss-Prot
      B1AW67, Q0VBL8, Q4VA55, Q7TSI2, Q8BS63
      UniProtKB/TrEMBL
      B2RPZ1
      Conserved Domains (1) summary
      cd06080
      Location:375 → 454
      MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...

    2. XM_006528541.1 → XP_006528604.1  PWWP domain-containing DNA repair factor 3B isoform X1

      See identical proteins and their annotated locations for XP_006528604.1

      UniProtKB/Swiss-Prot
      B1AW67, Q0VBL8, Q4VA55, Q7TSI2, Q8BS63
      UniProtKB/TrEMBL
      B2RPZ1
      Conserved Domains (1) summary
      cd06080
      Location:375 → 454
      MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...

    3. XM_006528543.1 → XP_006528606.1  PWWP domain-containing DNA repair factor 3B isoform X1

      See identical proteins and their annotated locations for XP_006528606.1

      UniProtKB/Swiss-Prot
      B1AW67, Q0VBL8, Q4VA55, Q7TSI2, Q8BS63
      UniProtKB/TrEMBL
      B2RPZ1
      Conserved Domains (1) summary
      cd06080
      Location:375 → 454
      MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...

    4. XM_017318499.2 → XP_017173988.1  PWWP domain-containing DNA repair factor 3B isoform X1

      UniProtKB/Swiss-Prot
      B1AW67, Q0VBL8, Q4VA55, Q7TSI2, Q8BS63
      UniProtKB/TrEMBL
      B2RPZ1
      Conserved Domains (1) summary
      cd06080
      Location:375 → 454
      MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...

    5. XM_030251345.1 → XP_030107205.1  PWWP domain-containing DNA repair factor 3B isoform X1

      UniProtKB/Swiss-Prot
      B1AW67, Q0VBL8, Q4VA55, Q7TSI2, Q8BS63
      UniProtKB/TrEMBL
      B2RPZ1
      Conserved Domains (1) summary
      cd06080
      Location:375 → 454
      MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4VA55.2 GenPept UniProtKB/Swiss-Prot:Q4VA55

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