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    BRCA1 BRCA1 DNA repair associated [ Pan paniscus (pygmy chimpanzee) ]

    Gene ID: 100986197, updated on 6-Jun-2024

    Summary

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    Gene symbol
    BRCA1
    Gene description
    BRCA1 DNA repair associated
    See related
    Ensembl:ENSPPAG00000030624
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pan paniscus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs
    human mouse all
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    Genomic context

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    See BRCA1 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanPan1-v2.0_pri (GCF_029289425.2) 19 NC_073268.2 (21865798..21957438)
    RS_2023_05 previous assembly NHGRI_mPanPan1-v1.1-0.1.freeze_pri (GCF_029289425.1) 17 NC_073266.1 (23755123..23836219)

    Chromosome 19 - NC_073268.2Genomic Context describing neighboring genes Neighboring gene transmembrane protein 106A Neighboring gene NBR1 autophagy cargo receptor Neighboring gene uncharacterized LOC130540913 Neighboring gene Rho family GTPase 2 Neighboring gene vesicle amine transport 1 Neighboring gene interferon induced protein 35

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evidence of a warfarin-sensitive cancer procoagulant in V2 carcinoma. Roncaglioni MC, et al. Haematologica, 1989 Mar-Apr. PMID 2501168
    2. Rapid evolution of BRCA1 and BRCA2 in humans and other primates. Lou DI, et al. BMC Evol Biol, 2014 Jul 11. PMID 25011685, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chordate embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in dosage compensation by inactivation of X chromosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of BRCA1-A complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of BRCA1-BARD1 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    breast cancer type 1 susceptibility protein
    Names
    BRCA1 homologue
    breast cancer type 1 susceptibility protein homolog
    NP_001288687.1
    XP_034797073.2
    XP_034797074.2
    XP_034797075.2
    XP_034797076.2
    XP_054956824.2
    XP_054956825.2
    XP_054956826.2
    XP_054956827.2
    XP_054956828.2
    XP_054956829.2
    XP_054956830.2
    XP_054956831.2
    XP_054956832.2
    XP_057156164.2
    XP_057156165.2
    XP_057156166.2
    XP_057156167.2
    XP_057156168.2
    XP_057156169.2
    XP_057156170.2
    XP_057156171.2
    XP_057156172.2
    XP_057156173.2
    XP_057156174.2
    XP_057156175.2
    XP_057156176.2
    XP_057156177.2
    XP_057156178.2
    XP_057156179.2
    XP_057156180.2
    XP_057156181.2
    XP_057156182.2
    XP_057156183.2
    XP_057156184.2
    XP_057156185.2
    XP_057156186.2
    XP_063454662.1
    XP_063454663.1
    XP_063454664.1
    XP_063454665.1
    XP_063454666.1
    XP_063454667.1
    XP_063454668.1
    XP_063454669.1
    XP_063454670.1
    XP_063454671.1
    XP_063454672.1
    XP_063454673.1
    XP_063454674.1
    XP_063454675.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301758.1 → NP_001288687.1  breast cancer type 1 susceptibility protein

      See identical proteins and their annotated locations for NP_001288687.1

      Status: PROVISIONAL

      Source sequence(s)
      KM017616
      UniProtKB/TrEMBL
      A0A075VQZ2, A0A2R9AJD0
      Related
      ENSPPAP00000015729.1, ENSPPAT00000038420.1
      Conserved Domains (4) summary
      smart00292
      Location:1758 → 1839
      BRCT; breast cancer carboxy-terminal domain
      cd00027
      Location:1650 → 1724
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      cd00162
      Location:23 → 68
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam12820
      Location:345 → 507
      BRCT_assoc; Serine-rich domain associated with BRCT

    RefSeqs of Annotated Genomes: GCF_029289425.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanPan1-v2.0_pri Primary Assembly

    Genomic

    1. NC_073268.2 Reference NHGRI_mPanPan1-v2.0_pri Primary Assembly

      Range
      21865798..21957438
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_055100850.3 → XP_054956825.2  breast cancer type 1 susceptibility protein isoform X5

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    2. XM_057300188.2 → XP_057156171.2  breast cancer type 1 susceptibility protein isoform X8

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    3. XM_063598593.1 → XP_063454663.1  breast cancer type 1 susceptibility protein isoform X17

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    4. XM_063598597.1 → XP_063454667.1  breast cancer type 1 susceptibility protein isoform X18

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    5. XM_055100852.3 → XP_054956827.2  breast cancer type 1 susceptibility protein isoform X7

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    6. XM_057300190.2 → XP_057156173.2  breast cancer type 1 susceptibility protein isoform X9

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    7. XM_057300194.2 → XP_057156177.2  breast cancer type 1 susceptibility protein isoform X10

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    8. XM_063598600.1 → XP_063454670.1  breast cancer type 1 susceptibility protein isoform X19

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    9. XM_057300196.2 → XP_057156179.2  breast cancer type 1 susceptibility protein isoform X13

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    10. XM_057300199.2 → XP_057156182.2  breast cancer type 1 susceptibility protein isoform X15

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    11. XM_057300185.2 → XP_057156168.2  breast cancer type 1 susceptibility protein isoform X5

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    12. XM_055100853.2 → XP_054956828.2  breast cancer type 1 susceptibility protein isoform X6

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    13. XM_057300187.2 → XP_057156170.2  breast cancer type 1 susceptibility protein isoform X8

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    14. XM_063598594.1 → XP_063454664.1  breast cancer type 1 susceptibility protein isoform X17

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    15. XM_057300186.2 → XP_057156169.2  breast cancer type 1 susceptibility protein isoform X7

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    16. XM_057300191.2 → XP_057156174.2  breast cancer type 1 susceptibility protein isoform X9

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    17. XM_063598601.1 → XP_063454671.1  breast cancer type 1 susceptibility protein isoform X19

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    18. XM_057300197.2 → XP_057156180.2  breast cancer type 1 susceptibility protein isoform X14

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    19. XM_057300184.2 → XP_057156167.2  breast cancer type 1 susceptibility protein isoform X4

      UniProtKB/TrEMBL
      A0A2R9AJD0

    20. XM_034941182.3 → XP_034797073.2  breast cancer type 1 susceptibility protein isoform X5

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    21. XM_034941183.3 → XP_034797074.2  breast cancer type 1 susceptibility protein isoform X6

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    22. XM_034941184.3 → XP_034797075.2  breast cancer type 1 susceptibility protein isoform X8

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    23. XM_055100855.2 → XP_054956830.2  breast cancer type 1 susceptibility protein isoform X11

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    24. XM_063598595.1 → XP_063454665.1  breast cancer type 1 susceptibility protein isoform X17

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    25. XM_063598598.1 → XP_063454668.1  breast cancer type 1 susceptibility protein isoform X18

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    26. XM_055100851.2 → XP_054956826.2  breast cancer type 1 susceptibility protein isoform X7

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    27. XM_055100854.2 → XP_054956829.2  breast cancer type 1 susceptibility protein isoform X9

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    28. XM_055100856.2 → XP_054956831.2  breast cancer type 1 susceptibility protein isoform X10

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    29. XM_055100857.2 → XP_054956832.2  breast cancer type 1 susceptibility protein isoform X12

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    30. XM_063598602.1 → XP_063454672.1  breast cancer type 1 susceptibility protein isoform X19

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    31. XM_063598604.1 → XP_063454674.1  breast cancer type 1 susceptibility protein isoform X20

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    32. XM_063598605.1 → XP_063454675.1  breast cancer type 1 susceptibility protein isoform X24

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    33. XM_057300183.2 → XP_057156166.2  breast cancer type 1 susceptibility protein isoform X3

      UniProtKB/TrEMBL
      A0A2R9AJD0

    34. XM_057300201.2 → XP_057156184.2  breast cancer type 1 susceptibility protein isoform X21

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    35. XM_057300203.2 → XP_057156186.2  breast cancer type 1 susceptibility protein isoform X23

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    36. XM_057300198.2 → XP_057156181.2  breast cancer type 1 susceptibility protein isoform X14

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    37. XM_055100849.2 → XP_054956824.2  breast cancer type 1 susceptibility protein isoform X5

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    38. XM_057300189.2 → XP_057156172.2  breast cancer type 1 susceptibility protein isoform X8

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    39. XM_057300193.2 → XP_057156176.2  breast cancer type 1 susceptibility protein isoform X11

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    40. XM_063598592.1 → XP_063454662.1  breast cancer type 1 susceptibility protein isoform X16

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    41. XM_063598596.1 → XP_063454666.1  breast cancer type 1 susceptibility protein isoform X17

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    42. XM_063598599.1 → XP_063454669.1  breast cancer type 1 susceptibility protein isoform X18

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    43. XM_034941185.3 → XP_034797076.2  breast cancer type 1 susceptibility protein isoform X7

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    44. XM_057300192.2 → XP_057156175.2  breast cancer type 1 susceptibility protein isoform X9

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    45. XM_057300195.2 → XP_057156178.2  breast cancer type 1 susceptibility protein isoform X10

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    46. XM_063598603.1 → XP_063454673.1  breast cancer type 1 susceptibility protein isoform X19

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    47. XM_057300200.2 → XP_057156183.2  breast cancer type 1 susceptibility protein isoform X15

      UniProtKB/TrEMBL
      A0A2R9AFJ2

    48. XM_057300181.2 → XP_057156164.2  breast cancer type 1 susceptibility protein isoform X1

      UniProtKB/TrEMBL
      A0A2R9AJD0

    49. XM_057300182.2 → XP_057156165.2  breast cancer type 1 susceptibility protein isoform X2

      UniProtKB/TrEMBL
      A0A2R9AJD0

    50. XM_057300202.2 → XP_057156185.2  breast cancer type 1 susceptibility protein isoform X22

      UniProtKB/TrEMBL
      A0A2R9AFJ2
    Nucleotide Protein
    Heading Accession and Version

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