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    rag2.S recombination activating gene 2 S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 100037211, updated on 11-Apr-2024

    Summary

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    Official Symbol
    rag2.S
    Official Full Name
    recombination activating gene 2 S homeolog
    Primary source
    Xenbase:XB-GENE-1018151
    Locus tag
    XELAEV_18024515mg
    See related
    EnsemblRapid:ENSXLAG00005023044
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    rag2
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    Genomic context

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    See rag2.S in Genome Data Viewer
    Location:
    chromosome: 4S
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4S NC_054378.1 (16048620..16077716, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4S NC_030731.1 (15456942..15485965, complement)

    Chromosome 4S - NC_054378.1Genomic Context describing neighboring genes Neighboring gene TNF receptor associated factor 6 S homeolog Neighboring gene recombination activating gene 1 S homeolog Neighboring gene uncharacterized LOC121393436 Neighboring gene ribosomal protein S6 kinase beta-2 Neighboring gene exostosin glycosyltransferase 2 S homeolog Neighboring gene ALX homeobox 4 S homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization and expression of recombination activating genes (RAG-1 and RAG-2) in Xenopus laevis. Greenhalgh P, et al. J Immunol, 1993 Sep 15. PMID 8376769
    2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidylinositol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidylinositol-3,5-bisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within T cell differentiation in thymus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within V(D)J recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within V(D)J recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA recombinase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    V(D)J recombination-activating protein 2
    Names
    RAG-2
    recombination activating protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001097900.1 → NP_001091369.1  V(D)J recombination-activating protein 2

      See identical proteins and their annotated locations for NP_001091369.1

      Status: PROVISIONAL

      Source sequence(s)
      BC129719
      UniProtKB/TrEMBL
      A2VDB6
      Conserved Domains (2) summary
      pfam03089
      Location:51 → 385
      RAG2; Recombination activating protein 2
      pfam13341
      Location:407 → 484
      RAG2_PHD; RAG2 PHD domain

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054378.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      16048620..16077716 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_018259243.2 → XP_018114732.1  V(D)J recombination-activating protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q91830
      UniProtKB/TrEMBL
      A0A1L8GDK5, A0A974HL03
      Conserved Domains (2) summary
      pfam03089
      Location:51 → 385
      RAG2; Recombination activating protein 2
      pfam13341
      Location:407 → 484
      RAG2_PHD; RAG2 PHD domain

    2. XM_041591103.1 → XP_041447037.1  V(D)J recombination-activating protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q91830
      UniProtKB/TrEMBL
      A0A1L8GDK5, A0A974HL03
      Related
      ENSXLAP00005068007.1, ENSXLAT00005069541.1
      Conserved Domains (2) summary
      pfam03089
      Location:51 → 385
      RAG2; Recombination activating protein 2
      pfam13341
      Location:407 → 484
      RAG2_PHD; RAG2 PHD domain

    3. XM_041591106.1 → XP_041447040.1  V(D)J recombination-activating protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q91830
      UniProtKB/TrEMBL
      A0A1L8GDK5, A0A974HL03
      Related
      ENSXLAP00005067978.1, ENSXLAT00005069512.1
      Conserved Domains (2) summary
      pfam03089
      Location:51 → 385
      RAG2; Recombination activating protein 2
      pfam13341
      Location:407 → 484
      RAG2_PHD; RAG2 PHD domain

    4. XM_041591104.1 → XP_041447038.1  V(D)J recombination-activating protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q91830
      UniProtKB/TrEMBL
      A0A1L8GDK5, A0A974HL03
      Related
      ENSXLAP00005067986.1, ENSXLAT00005069520.1
      Conserved Domains (2) summary
      pfam03089
      Location:51 → 385
      RAG2; Recombination activating protein 2
      pfam13341
      Location:407 → 484
      RAG2_PHD; RAG2 PHD domain

    5. XM_041591102.1 → XP_041447036.1  V(D)J recombination-activating protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q91830
      UniProtKB/TrEMBL
      A0A1L8GDK5, A0A974HL03
      Related
      ENSXLAP00005067994.1, ENSXLAT00005069528.1
      Conserved Domains (2) summary
      pfam03089
      Location:51 → 385
      RAG2; Recombination activating protein 2
      pfam13341
      Location:407 → 484
      RAG2_PHD; RAG2 PHD domain

    6. XM_041591107.1 → XP_041447041.1  V(D)J recombination-activating protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q91830
      UniProtKB/TrEMBL
      A0A1L8GDK5, A0A974HL03
      Related
      ENSXLAP00005067940.1, ENSXLAT00005069474.1
      Conserved Domains (2) summary
      pfam03089
      Location:51 → 385
      RAG2; Recombination activating protein 2
      pfam13341
      Location:407 → 484
      RAG2_PHD; RAG2 PHD domain

    7. XM_041591105.1 → XP_041447039.1  V(D)J recombination-activating protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q91830
      UniProtKB/TrEMBL
      A0A1L8GDK5, A0A974HL03
      Related
      ENSXLAP00005067921.1, ENSXLAT00005069455.1
      Conserved Domains (2) summary
      pfam03089
      Location:51 → 385
      RAG2; Recombination activating protein 2
      pfam13341
      Location:407 → 484
      RAG2_PHD; RAG2 PHD domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91830.1 GenPept UniProtKB/Swiss-Prot:Q91830

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