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    Gcnt3 glucosaminyl (N-acetyl) transferase 3, mucin type [ Rattus norvegicus (Norway rat) ]

    Gene ID: 286976, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Gcnt3provided by RGD
    Official Full Name
    glucosaminyl (N-acetyl) transferase 3, mucin typeprovided by RGD
    Primary source
    RGD:631333
    See related
    EnsemblRapid:ENSRNOG00000059540 AllianceGenome:RGD:631333
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    dIGnT; C2GnT-M; dI/C2/C4GnT
    Summary
    Enables N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity. Predicted to be involved in protein glycosylation. Predicted to act upstream of or within intestinal absorption; kidney morphogenesis; and tissue morphogenesis. Predicted to be located in Golgi membrane. Orthologous to human GCNT3 (glucosaminyl (N-acetyl) transferase 3, mucin type). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 9.0), Liver (RPKM 3.2) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gcnt3 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (79570081..79577389, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (70689173..70696476, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (76449078..76459431, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene BCL2 interacting protein 2 Neighboring gene general transcription factor 2A subunit 2 Neighboring gene selenoprotein K, pseudogene 1 Neighboring gene family with sequence similarity 81, member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Purification and cDNA cloning of UDP-GlcNAc:GlcNAcbeta1-3Galbeta1-4Glc(NAc)-R [GlcNAc to Gal]beta1,6N-acetylglucosaminyltransferase from rat small intestine: a major carrier of dIGnT activity in rat small intestine. Korekane H, et al. Glycobiology, 2003 May. PMID 12626393
    2. Glycosyltransferase function in core 2-type protein O glycosylation. Stone EL, et al. Mol Cell Biol, 2009 Jul. PMID 19349303, Free PMC Article
    3. Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation. Zhang T, et al. Genome Res, 2004 Jan. PMID 14672974, Free PMC Article
    4. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. purification, cloning and sequencing of enzyme from small intestine; significant homology with human and virus enzyme
      Title: Purification and cDNA cloning of UDP-GlcNAc:GlcNAcbeta1-3Galbeta1-4Glc(NAc)-R [GlcNAc to Gal]beta1,6N-acetylglucosaminyltransferase from rat small intestine: a major carrier of dIGnT activity in rat small intestine.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within intestinal absorption ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within kidney morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tissue morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3
    Names
    C2GnT-mucin type
    beta-1,6-N-acetylglucosaminyltransferase
    beta-16-N-acetylglucosaminyltransferase
    NP_775434.1
    XP_006243428.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433050.1 → NP_001419979.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q8CH87
      UniProtKB/TrEMBL
      A6KEU3

    2. NM_173312.3 → NP_775434.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3

      See identical proteins and their annotated locations for NP_775434.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q8CH87
      UniProtKB/TrEMBL
      A6KEU2, A6KEU3
      Related
      ENSRNOP00000081773.1, ENSRNOT00000112837.2
      Conserved Domains (1) summary
      pfam02485
      Location:133 → 400
      Branch; Core-2/I-Branching enzyme

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      79570081..79577389 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243366.5 → XP_006243428.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 isoform X1

      Related
      ENSRNOP00000093903.1, ENSRNOT00000106219.2
      Conserved Domains (1) summary
      pfam02485
      Location:133 → 400
      Branch; Core-2/I-Branching enzyme
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CH87.1 GenPept UniProtKB/Swiss-Prot:Q8CH87

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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