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    ap2m1b adaptor related protein complex 2 subunit mu 1b [ Danio rerio (zebrafish) ]

    Gene ID: 394001, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ap2m1bprovided by ZNC
    Official Full Name
    adaptor related protein complex 2 subunit mu 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1103
    See related
    Ensembl:ENSDARG00000033899 AllianceGenome:ZFIN:ZDB-GENE-040426-1103
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ap2m1; zgc:56643
    Summary
    Predicted to enable clathrin adaptor activity. Acts upstream of or within Wnt signaling pathway. Predicted to be located in clathrin-coated pit and plasma membrane. Predicted to be part of AP-2 adaptor complex. Predicted to be active in cytoplasmic vesicle. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human AP2M1 (adaptor related protein complex 2 subunit mu 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See ap2m1b in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (45955005..45984585)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (45956972..45986567)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene arginyl aminopeptidase like 1 Neighboring gene dishevelled segment polarity protein 3 Neighboring gene microRNA 737 Neighboring gene uncharacterized LOC137488339 Neighboring gene matrix metallopeptidase 23bb Neighboring gene phosphate cytidylyltransferase 1A, choline b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification and functional characterization of AP-2 complex subunit mu-A as a new member of antimicrobial protein. Gong Y, et al. Dev Comp Immunol, 2021 Aug. PMID 33848529
    2. In vivo analysis of formation and endocytosis of the Wnt/β-catenin signaling complex in zebrafish embryos. Hagemann AI, et al. J Cell Sci, 2014 Sep 15. PMID 25074807, Free PMC Article
    3. Quantitative proteomics analysis of zebrafish exposed to sub-lethal dosages of β-methyl-amino-L-alanine (BMAA). Frøyset AK, et al. Sci Rep, 2016 Jul 12. PMID 27404450, Free PMC Article
    4. Screen for genes differentially expressed during regeneration of the zebrafish caudal fin. Padhi BK, et al. Dev Dyn, 2004 Nov. PMID 15376328
    5. Zebrafish miR-1 and miR-133 shape muscle gene expression and regulate sarcomeric actin organization. Mishima Y, et al. Genes Dev, 2009 Mar 1. PMID 19240126, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC56643

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables clathrin adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-2 adaptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of clathrin adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    AP-2 complex subunit mu-B
    Names
    AP-2 complex subunit mu-1-B
    AP-2 mu-2 chain B
    AP-2 mu-B chain
    adaptor-related protein complex 2, mu 1 subunit, b
    clathrin assembly protein complex 2 medium chain B
    clathrin assembly protein complex 2 mu-B medium chain
    clathrin coat assembly protein AP50-B
    clathrin coat-associated protein AP50-B
    mu2-adaptin-B
    plasma membrane adaptor AP-2 50 kDa protein B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201026.2 → NP_957320.1  AP-2 complex subunit mu-B

      See identical proteins and their annotated locations for NP_957320.1

      Status: PROVISIONAL

      Source sequence(s)
      BC049515
      UniProtKB/Swiss-Prot
      Q7ZW98
      Related
      ENSDARP00000126276.1, ENSDART00000151418.3
      Conserved Domains (1) summary
      cd09251
      Location:168 → 435
      AP-2_Mu2_Cterm; C-terminal domain of medium Mu2 subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-2

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      45955005..45984585
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068214744.1 → XP_068070845.1  AP-2 complex subunit mu-B isoform X1

    2. XM_068214745.1 → XP_068070846.1  AP-2 complex subunit mu-B isoform X2

      Related
      ENSDARP00000126148.1, ENSDART00000151112.3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7ZW98.1 GenPept UniProtKB/Swiss-Prot:Q7ZW98

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