shot short stop [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: shotprovided by FlyBase
Official Full Name: short stopprovided by FlyBase
Primary source: FLYBASE:FBgn0013733
Locus tag: Dmel_CG18076
See related: AllianceGenome:FB:FBgn0013733
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 42/4; CG18076; CG18637; Dmel\CG18076; EN2-12; grv; Grv; kak; Kak; kakp; kop; l(2)CA4; l(2)k03010; l(2)k04204; l(2)k05434; l(2)k05821; l(2)k10821; l(2)k15606; shortstop/kakapo; Shot; Su(Mir)1
Summary: Enables cytoskeletal anchor activity. Involved in several processes, including cytoskeleton organization; neuron projection morphogenesis; and open tracheal system development. Located in several cellular components, including anterior cell cortex; fusome; and microtubule. Is expressed in several structures, including adult efferent neurons; denticle row; gut section; internal sense organ; and presumptive embryonic/larval system. Used to study cancer. Human ortholog(s) of this gene implicated in epidermolysis bullosa simplex; hereditary sensory and autonomic neuropathy type 6; and lissencephaly 9 with complex brainstem malformation. Orthologous to human DST (dystonin) and MACF1 (microtubule actin crosslinking factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 50C6-50C9; 2-68 cM

Exon count:: 43

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (13864237..13942110, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (9751742..9829615, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Shot CH1 domain recognises a distinct form of F-actin during Drosophila oocyte determination.
Title: The Shot CH1 domain recognises a distinct form of F-actin during Drosophila oocyte determination.
Loss of the spectraplakin gene Short stop induces a DNA damage response in Drosophila epithelia.
Title: Loss of the spectraplakin gene Short stop induces a DNA damage response in Drosophila epithelia.
Coordinated crosstalk between microtubules and actin by a spectraplakin regulates lumen formation and branching.
Title: Coordinated crosstalk between microtubules and actin by a spectraplakin regulates lumen formation and branching.
The spectraplakin Dystonin antagonizes YAP activity and suppresses tumourigenesis.
Title: The spectraplakin Dystonin antagonizes YAP activity and suppresses tumourigenesis.
Shot crosslinks F-actin and microtubules around the intra-axonal boundary, directing T antigen-carrying vesicles toward the proximal plasma membrane.
Title: Short stop mediates axonal compartmentalization of mucin-type core 1 glycans.
Patronin and Shot then act to polarise microtubules along the apical-basal axis to enable apical transport of Rab11 endosomes by the Nuf-Dynein microtubule motor complex. Finally, Rab11 endosomes are transferred to the MyoV (also known as Didum in Drosophila) actin motor to deliver the key microvillar determinant Cadherin 99C to the apical membrane to organise the biogenesis of actin microvilli.
Title: Shot and Patronin polarise microtubules to direct membrane traffic and biogenesis of microvilli in epithelia.
Shot-mediated interactions between microtubules and actin filaments facilitate filopodia formation, which promotes zippering by initiating contact between opposing epithelial cells.
Title: The spectraplakin Short stop is an essential microtubule regulator involved in epithelial closure in Drosophila.
Tau and spectraplakin promote synapse formation and maintenance through Jun kinase and neuronal trafficking.
Title: Tau and spectraplakins promote synapse formation and maintenance through Jun kinase and neuronal trafficking.
Shot/Patronin foci are excluded from the oocyte posterior by the Par-1 polarity kinase to generate the polarized microtubule network that localizes axis determinants
Title: Patronin/Shot Cortical Foci Assemble the Noncentrosomal Microtubule Array that Specifies the Drosophila Anterior-Posterior Axis.
shot is a key player in establishing the cytoskeletal arrangement required for the spatial localization of axis-determining maternal mRNAs.
Title: shot regulates the microtubule reorganization required for localization of axis-determining mRNAs during oogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables actin binding	TAS Traceable Author Statement more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal anchor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural molecule activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin cytoskeleton organization	TAS Traceable Author Statement more info	PubMed
involved_in axon midline choice point recognition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axoneme assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonogenesis	TAS Traceable Author Statement more info	PubMed
involved_in branch fusion, open tracheal system	IEP Inferred from Expression Pattern more info	PubMed
involved_in branch fusion, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in branching involved in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cortical microtubule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoplasmic microtubule organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intermediate filament cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in intermediate filament cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in lumen formation, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule bundle formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule cytoskeleton organization	TAS Traceable Author Statement more info	PubMed
involved_in microtubule-based process	IDA Inferred from Direct Assay more info	PubMed
involved_in microtubule-based process	NAS Non-traceable Author Statement more info	PubMed
involved_in mushroom body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of microtubule depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in open tracheal system development	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of filopodium assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in adherens junction	TAS Traceable Author Statement more info	PubMed
located_in anterior cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in astral microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in axonal growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	NAS Non-traceable Author Statement more info	PubMed
located_in filopodium	IDA Inferred from Direct Assay more info	PubMed
located_in fusome	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
is_active_in hemidesmosome	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with intermediate filament	IBA Inferred from Biological aspect of Ancestor more info
located_in lateral cell cortex	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule plus-end	IDA Inferred from Direct Assay more info	PubMed
located_in muscle tendon junction	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: short stop

Names: CG18076-PA; CG18076-PAA; CG18076-PAB; CG18076-PAC; CG18076-PAD; CG18076-PB; CG18076-PC; CG18076-PE; CG18076-PG; CG18076-PH; CG18076-PI; CG18076-PJ; CG18076-PK; CG18076-PL; CG18076-PM; CG18076-PN; CG18076-PO; CG18076-PP; CG18076-PQ; CG18076-PX; CG18076-PY; CG18076-PZ; enhancer of NA9 2-12; groovin; kakapo; kakapoo; kopupu; short-stop; shortshop; shortstop; shot; shot-PA; shot-PAA; shot-PAB; shot-PAC; shot-PAD; shot-PB; shot-PC; shot-PE; shot-PG; shot-PH; shot-PI; shot-PJ; shot-PK; shot-PL; shot-PM; shot-PN; shot-PO; shot-PP; shot-PQ; shot-PX; shot-PY; shot-PZ; spectraplakin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

13864237..13942110 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001144187.2 → NP_001137659.1 short stop, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001137659.1

Status: REVIEWED

UniProtKB/TrEMBL

B7YZG2, Q7KJN8

Conserved Domains (9) summary

smart00243
Location:5020 → 5092

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00250
Location:1428 → 1456

PLEC; Plectin repeat

cd00014
Location:38 → 140

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00051
Location:4945 → 5007

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:4113 → 4332

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:153 → 252

CH; Calponin homology (CH) domain

pfam13499
Location:4946 → 5006

EF-hand_7; EF-hand domain pair

cl02488
Location:273 → 482

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl17036
Location:815 → 852

SH3; Src Homology 3 domain superfamily
NM_001144185.2 → NP_001137657.1 short stop, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001137657.1

Status: REVIEWED

UniProtKB/TrEMBL

B7YZG3, Q7KJN8

Conserved Domains (9) summary

smart00243
Location:5020 → 5092

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00250
Location:1428 → 1456

PLEC; Plectin repeat

cd00014
Location:38 → 140

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00051
Location:4945 → 5007

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:4113 → 4332

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:153 → 252

CH; Calponin homology (CH) domain

pfam13499
Location:4946 → 5006

EF-hand_7; EF-hand domain pair

cl02488
Location:273 → 482

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl17036
Location:815 → 852

SH3; Src Homology 3 domain superfamily
NM_166015.2 → NP_725335.1 short stop, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725335.1

Status: REVIEWED

UniProtKB/TrEMBL

A1Z9I8, Q7KJN8

Related

FBpp0086743

Conserved Domains (9) summary

smart00243
Location:5035 → 5107

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00250
Location:1428 → 1456

PLEC; Plectin repeat

cd00014
Location:38 → 140

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00051
Location:4960 → 5022

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:4113 → 4332

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:153 → 252

CH; Calponin homology (CH) domain

pfam13499
Location:4961 → 5021

EF-hand_7; EF-hand domain pair

cl02488
Location:273 → 482

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl17036
Location:815 → 852

SH3; Src Homology 3 domain superfamily
NM_001144186.2 → NP_001137658.1 short stop, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001137658.1

Status: REVIEWED

UniProtKB/TrEMBL

B7YZG4, Q7KJN8

Conserved Domains (9) summary

smart00243
Location:5035 → 5107

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00250
Location:1428 → 1456

PLEC; Plectin repeat

cd00014
Location:38 → 140

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00051
Location:4960 → 5022

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:4113 → 4332

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:153 → 252

CH; Calponin homology (CH) domain

pfam13499
Location:4961 → 5021

EF-hand_7; EF-hand domain pair

cl02488
Location:273 → 482

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl17036
Location:815 → 852

SH3; Src Homology 3 domain superfamily
NM_166016.2 → NP_725336.1 short stop, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725336.1

Status: REVIEWED

UniProtKB/TrEMBL

A1Z9I9, Q7KJN8

Related

FBpp0086742

Conserved Domains (9) summary

smart00243
Location:5035 → 5107

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00250
Location:1428 → 1456

PLEC; Plectin repeat

cd00014
Location:38 → 140

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00051
Location:4960 → 5022

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:4113 → 4332

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:153 → 252

CH; Calponin homology (CH) domain

pfam13499
Location:4961 → 5021

EF-hand_7; EF-hand domain pair

cl02488
Location:273 → 482

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl17036
Location:815 → 852

SH3; Src Homology 3 domain superfamily
NM_001169677.1 → NP_001163148.1 short stop, isoform N [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163148.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JH62, Q7KJN8

Conserved Domains (9) summary

smart00243
Location:5055 → 5127

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00250
Location:1428 → 1456

PLEC; Plectin repeat

cd00014
Location:38 → 140

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00051
Location:4980 → 5042

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:4113 → 4332

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:153 → 252

CH; Calponin homology (CH) domain

pfam13499
Location:4981 → 5041

EF-hand_7; EF-hand domain pair

cl02488
Location:273 → 482

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl17036
Location:815 → 852

SH3; Src Homology 3 domain superfamily
NM_001259381.1 → NP_001246310.1 short stop, isoform AA [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246310.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K7Y9, Q7KJN8

Conserved Domains (9) summary

smart00243
Location:5075 → 5147

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00250
Location:1448 → 1476

PLEC; Plectin repeat

cd00014
Location:38 → 160

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00051
Location:5000 → 5062

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:4133 → 4352

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:173 → 272

CH; Calponin homology (CH) domain

pfam13499
Location:5001 → 5061

EF-hand_7; EF-hand domain pair

cl02488
Location:293 → 502

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl17036
Location:835 → 872

SH3; Src Homology 3 domain superfamily
NM_001259380.1 → NP_001246309.1 short stop, isoform Z [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246309.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K7P8, Q7KJN8

Conserved Domains (9) summary

smart00243
Location:5061 → 5133

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00250
Location:1434 → 1462

PLEC; Plectin repeat

cd00014
Location:38 → 146

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00051
Location:4986 → 5048

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:4119 → 4338

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:159 → 258

CH; Calponin homology (CH) domain

pfam13499
Location:4987 → 5047

EF-hand_7; EF-hand domain pair

cl02488
Location:279 → 488

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl17036
Location:821 → 858

SH3; Src Homology 3 domain superfamily
NM_166017.2 → NP_725337.1 short stop, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725337.1

Status: REVIEWED

UniProtKB/TrEMBL

A1Z9J0, Q7KJN8

Related

FBpp0086744

Conserved Domains (8) summary

smart00243
Location:4846 → 4918

GAS2; Growth-Arrest-Specific Protein 2 Domain

cd00014
Location:149 → 251

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00051
Location:4771 → 4833

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:3924 → 4143

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:264 → 363

CH; Calponin homology (CH) domain

pfam13499
Location:4772 → 4832

EF-hand_7; EF-hand domain pair

cl02488
Location:384 → 593

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl17036
Location:926 → 963

SH3; Src Homology 3 domain superfamily
NM_001144188.2 → NP_001137660.1 short stop, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001137660.1

Status: REVIEWED

UniProtKB/TrEMBL

B7YZG5, Q7KJN8

Conserved Domains (9) summary

smart00243
Location:5131 → 5203

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00250
Location:1539 → 1567

PLEC; Plectin repeat

cd00014
Location:149 → 251

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00051
Location:5056 → 5118

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:4224 → 4443

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:264 → 363

CH; Calponin homology (CH) domain

pfam13499
Location:5057 → 5117

EF-hand_7; EF-hand domain pair

cl02488
Location:384 → 593

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl17036
Location:926 → 963

SH3; Src Homology 3 domain superfamily
NM_001144189.2 → NP_001137661.1 short stop, isoform M [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001137661.1

Status: REVIEWED

UniProtKB/TrEMBL

B7YZG6, Q7KJN8

Conserved Domains (9) summary

smart00243
Location:5146 → 5218

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00250
Location:1539 → 1567

PLEC; Plectin repeat

cd00014
Location:149 → 251

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00051
Location:5071 → 5133

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:4224 → 4443

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:264 → 363

CH; Calponin homology (CH) domain

pfam13499
Location:5072 → 5132

EF-hand_7; EF-hand domain pair

cl02488
Location:384 → 593

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl17036
Location:926 → 963

SH3; Src Homology 3 domain superfamily
NM_079009.3 → NP_523733.2 short stop, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523733.2

Status: REVIEWED

UniProtKB/TrEMBL

A1Z9J1, Q7KJN8

Related

FBpp0086745

Conserved Domains (9) summary

smart00243
Location:5146 → 5218

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00250
Location:1539 → 1567

PLEC; Plectin repeat

cd00014
Location:149 → 251

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00051
Location:5071 → 5133

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:4224 → 4443

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:264 → 363

CH; Calponin homology (CH) domain

pfam13499
Location:5072 → 5132

EF-hand_7; EF-hand domain pair

cl02488
Location:384 → 593

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl17036
Location:926 → 963

SH3; Src Homology 3 domain superfamily
NM_001169678.1 → NP_001163149.1 short stop, isoform O [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163149.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JH63, Q7KJN8

Conserved Domains (9) summary

smart00243
Location:5166 → 5238

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00250
Location:1539 → 1567

PLEC; Plectin repeat

cd00014
Location:149 → 251

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00051
Location:5091 → 5153

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:4224 → 4443

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:264 → 363

CH; Calponin homology (CH) domain

pfam13499
Location:5092 → 5152

EF-hand_7; EF-hand domain pair

cl02488
Location:384 → 593

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl17036
Location:926 → 963

SH3; Src Homology 3 domain superfamily
NM_001169676.1 → NP_001163147.1 short stop, isoform Q [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163147.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JH64, Q7KJN8

Conserved Domains (7) summary

smart00243
Location:4805 → 4877

GAS2; Growth-Arrest-Specific Protein 2 Domain

cd00051
Location:4730 → 4792

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:3883 → 4102

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:223 → 322

CH; Calponin homology (CH) domain

pfam13499
Location:4731 → 4791

EF-hand_7; EF-hand domain pair

cl02488
Location:343 → 552

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl17036
Location:885 → 922

SH3; Src Homology 3 domain superfamily
NM_166018.3 → NP_725338.1 short stop, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725338.1

Status: REVIEWED

UniProtKB/TrEMBL

A1Z9J2, Q7KJN8

Related

FBpp0086746

Conserved Domains (7) summary

smart00243
Location:4805 → 4877

GAS2; Growth-Arrest-Specific Protein 2 Domain

cd00051
Location:4730 → 4792

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:3883 → 4102

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:223 → 322

CH; Calponin homology (CH) domain

pfam13499
Location:4731 → 4791

EF-hand_7; EF-hand domain pair

cl02488
Location:343 → 552

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl17036
Location:885 → 922

SH3; Src Homology 3 domain superfamily
NM_001259378.1 → NP_001246307.1 short stop, isoform X [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246307.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K869, Q7KJN8

Conserved Domains (8) summary

smart00243
Location:5101 → 5173

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00250
Location:1498 → 1526

PLEC; Plectin repeat

cd00051
Location:5026 → 5088

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:4183 → 4402

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:223 → 322

CH; Calponin homology (CH) domain

pfam13499
Location:5027 → 5087

EF-hand_7; EF-hand domain pair

cl02488
Location:343 → 552

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl17036
Location:885 → 922

SH3; Src Homology 3 domain superfamily
NM_001169679.2 → NP_001163150.1 short stop, isoform P [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163150.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JH65, Q7KJN8

Conserved Domains (8) summary

smart00243
Location:5125 → 5197

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00250
Location:1498 → 1526

PLEC; Plectin repeat

cd00051
Location:5050 → 5112

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:4183 → 4402

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:223 → 322

CH; Calponin homology (CH) domain

pfam13499
Location:5051 → 5111

EF-hand_7; EF-hand domain pair

cl02488
Location:343 → 552

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl17036
Location:885 → 922

SH3; Src Homology 3 domain superfamily
NM_001259379.1 → NP_001246308.1 short stop, isoform Y [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246308.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K867, Q7KJN8

Conserved Domains (8) summary

smart00243
Location:5125 → 5197

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00250
Location:1498 → 1526

PLEC; Plectin repeat

cd00051
Location:5050 → 5112

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:4183 → 4402

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:223 → 322

CH; Calponin homology (CH) domain

pfam13499
Location:5051 → 5111

EF-hand_7; EF-hand domain pair

cl02488
Location:343 → 552

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl17036
Location:885 → 922

SH3; Src Homology 3 domain superfamily
NM_001259383.1 → NP_001246312.1 short stop, isoform AC [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246312.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K788, Q7KJN8

Conserved Domains (8) summary

smart00243
Location:5129 → 5201

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00250
Location:1498 → 1526

PLEC; Plectin repeat

cd00051
Location:5054 → 5116

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:4187 → 4406

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:223 → 322

CH; Calponin homology (CH) domain

pfam13499
Location:5055 → 5115

EF-hand_7; EF-hand domain pair

cl02488
Location:343 → 552

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl17036
Location:885 → 922

SH3; Src Homology 3 domain superfamily
NM_166019.3 → NP_725339.1 short stop, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725339.1

Status: REVIEWED

UniProtKB/TrEMBL

A1Z9J3

Related

FBpp0086747

Conserved Domains (14) summary

smart00243
Location:8450 → 8522

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00250
Location:1498 → 1526

PLEC; Plectin repeat

COG5069
Location:204 → 420

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00176
Location:7528 → 7747

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:223 → 327

CH; Calponin homology (CH) domain

pfam00681
Location:1949 → 1981

Plectin; Plectin repeat

pfam13499
Location:8373 → 8437

EF-hand_7; EF-hand domain pair

cl02488
Location:5658 → 5787

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl17036
Location:885 → 922

SH3; Src Homology 3 domain superfamily

cl25732
Location:4904 → 5566

SMC_N; RecF/RecN/SMC N terminal domain

cl25758
Location:3026 → 3357

DUF4775; Domain of unknown function (DUF4775)

cl26247
Location:2711 → 3178

DNA_pol3_delta2; DNA polymerase III, delta subunit

cl28033
Location:8550 → 8795

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

cl28146
Location:6279 → 6441

PRK09039; hypothetical protein; Validated
NM_001259382.1 → NP_001246311.1 short stop, isoform AB [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246311.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K718, O96936

Conserved Domains (6) summary

smart00243
Location:3767 → 3839

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00250
Location:140 → 168

PLEC; Plectin repeat

cd00051
Location:3692 → 3754

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:2825 → 3044

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam13499
Location:3693 → 3753

EF-hand_7; EF-hand domain pair

cl02488
Location:354 → 599

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
NM_001259384.1 → NP_001246313.1 short stop, isoform AD [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246313.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K869, Q7KJN8

Conserved Domains (8) summary

smart00243
Location:5101 → 5173

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00250
Location:1498 → 1526

PLEC; Plectin repeat

cd00051
Location:5026 → 5088

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:4183 → 4402

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:223 → 322

CH; Calponin homology (CH) domain

pfam13499
Location:5027 → 5087

EF-hand_7; EF-hand domain pair

cl02488
Location:343 → 552

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl17036
Location:885 → 922

SH3; Src Homology 3 domain superfamily

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A0A0B4K718		A0A0B4K718
A0A0B4K788		A0A0B4K788
A0A0B4K7P8		A0A0B4K7P8
A0A0B4K7Y9		A0A0B4K7Y9
A0A0B4K867		A0A0B4K867
A0A0B4K869		A0A0B4K869
A1Z9I8		A1Z9I8
A1Z9I9		A1Z9I9
A1Z9J0		A1Z9J0
A1Z9J1		A1Z9J1
A1Z9J2		A1Z9J2
A1Z9J3		A1Z9J3
B7YZG2		B7YZG2
B7YZG3		B7YZG3
B7YZG4		B7YZG4
B7YZG5		B7YZG5
B7YZG6		B7YZG6
E1JH62		E1JH62
E1JH63		E1JH63
E1JH64		E1JH64
E1JH65		E1JH65
O77291		O77291
O96936		O96936
Q7KAJ2		Q7KAJ2
Q7KJN8		Q7KJN8
Q7KJN9		Q7KJN9
Q8MR19		Q8MR19
Q9U479		Q9U479