msh2 mutS homolog 2 (E. coli) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: msh2provided by ZNC
Official Full Name: mutS homolog 2 (E. coli)provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2932
See related: Ensembl:ENSDARG00000018022 AllianceGenome:ZFIN:ZDB-GENE-040426-2932
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55333; wu:fc06b02; wu:fc13e09
Summary: Enables guanine/thymine mispair binding activity. Acts upstream of or within maintenance of DNA repeat elements. Predicted to be part of MutSalpha complex. Predicted to be active in nucleus. Is expressed in alar plate midbrain region; immature eye; nervous system; and pharyngeal arch 3-7 skeleton. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome (multiple); gastrointestinal system cancer (multiple); lung cancer (multiple); mismatch repair cancer syndrome; and transitional cell carcinoma. Orthologous to human MSH2 (mutS homolog 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (24906108..24928497, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (24784889..24807278, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification and characterization of novel knockout mutants of the three major MMR genes, mlh1, msh2, and msh6, in zebrafish that develop tumors at low frequencies.
Title: Zebrafish with mutations in mismatch repair genes develop neurofibromas and other tumors.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fb92h06.y1 (e-PCR)
- UniSTS:191774

AI626431 (e-PCR)
- UniSTS:206135

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent DNA damage sensor activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables guanine/thymine mispair binding	IDA Inferred from Direct Assay more info	PubMed
enables guanine/thymine mispair binding	IGI Inferred from Genetic Interaction more info	PubMed
enables mismatched DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mismatched DNA binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within maintenance of DNA repeat elements	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mismatch repair	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mismatch repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mismatch repair	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in mitotic recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in somatic recombination of immunoglobulin genes involved in immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of MutSalpha complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA mismatch repair protein Msh2

Names: mismatch repair protein Msh2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213524.1 → NP_998689.1 DNA mismatch repair protein Msh2

See identical proteins and their annotated locations for NP_998689.1

Status: PROVISIONAL

Source sequence(s)

BC044370

UniProtKB/TrEMBL

Q803R6

Related

ENSDARP00000027768.6, ENSDART00000002465.7

Conserved Domains (6) summary

cd03285
Location:633 → 852

ABC_MSH2_euk; ATP-binding cassette domain of eukaryotic MutS2 homolog

COG0249
Location:23 → 911

MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]

pfam01624
Location:17 → 129

MutS_I; MutS domain I

pfam05188
Location:158 → 283

MutS_II; MutS domain II

pfam05190
Location:473 → 569

MutS_IV; MutS family domain IV

pfam05192
Location:305 → 423

MutS_III; MutS domain III