Or10j5 olfactory receptor family 10 subfamily J member 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Or10j5provided by MGI
Official Full Name: olfactory receptor family 10 subfamily J member 5provided by MGI
Primary source: MGI:MGI:106648
See related: Ensembl:ENSMUSG00000037924 AllianceGenome:MGI:106648
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MOR23; Olfr16; MOR26713
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
Orthologs: human all
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Genomic context

Location:: 1 H3; 1 80.33 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (172784335..172785384)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (172956768..172957817)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MOR23 deficiency exacerbates hepatic steatosis in mice.
Title: MOR23 deficiency exacerbates hepatic steatosis in mice.
This odorant receptor, Olfr16, responds to the odorant bourgeonal in both in vivo and in vitro assays.
Title: Modulation of the combinatorial code of odorant receptor response patterns in odorant mixtures.
A Reduction in MOR23 Expression Impaired the cAMP Signaling Pathway and Upregulated the Expression of Adipogenic Genes. MOR23 Depletion Decreases the Expression of Thermogenic and Mitochondrial Genes.
Title: Regulation of Adipogenesis and Thermogenesis through Mouse Olfactory Receptor 23 Stimulated by α-Cedrene in 3T3-L1 Cells.
The decrease of myofiber branching in mdx mouse muscles over-expressing mOR23 reduced the amount of membrane damage induced by mechanical stress.
Title: Decrease of myofiber branching via muscle-specific expression of the olfactory receptor mOR23 in dystrophic muscle leads to protection against mechanical stress.
The MOR23 glomeruli in the olfactory bulb of mice are formed postnatally, but the axon terminals of olfactory sensory neurons expressing this gene may be synaptically active in the olfactory bulb at embryonic stages.
Title: Odorant responsiveness of embryonic mouse olfactory sensory neurons expressing the odorant receptors S1 or MOR23.
Patch clamp recording from olfactory sensory neurons that express a defined odorant receptor provides a powerful approach to investigate the sensory inputs to individual glomeruli
Title: Odorant responses of olfactory sensory neurons expressing the odorant receptor MOR23: a patch clamp analysis in gene-targeted mice.
Mouse OR23 (MOR23) expression is induced during muscle regeneration when muscle cells are extensively fusing and plays a key role in regulating migration and adhesion of muscle cells in vitro.
Title: MOR23 promotes muscle regeneration and regulates cell adhesion and migration.
The receptive range of MOR23-1 is unique to its odorant space region.
Title: Molecular receptive range variation among mouse odorant receptors for aliphatic carboxylic acids.
MOR23 (a mouse OR expressed in the olfactory epithelium and testis) functions as a chemosensing receptor in mouse germ cells
Title: Functional characterization of a mouse testicular olfactory receptor and its role in chemosensing and in regulation of sperm motility.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:492574

Olfr16 (e-PCR), detects polymorphism
- UniSTS:531359

X92969 (e-PCR)
- UniSTS:125890

Olfr16 (e-PCR), detects polymorphism
- UniSTS:144082

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables olfactory receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables olfactory receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables olfactory receptor activity	ISA Inferred from Sequence Alignment more info	PubMed
enables olfactory receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISA Inferred from Sequence Alignment more info	PubMed
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in detection of chemical stimulus involved in sensory perception of smell	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of chemical stimulus involved in sensory perception of smell	IEA Inferred from Electronic Annotation more info
involved_in lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid homeostasis	ISO Inferred from Sequence Orthology more info
involved_in muscle organ development	IEA Inferred from Electronic Annotation more info
involved_in regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of smell	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sensory perception of smell	ISA Inferred from Sequence Alignment more info	PubMed
involved_in sensory perception of smell	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
located_in membrane	ISA Inferred from Sequence Alignment more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: olfactory receptor 10J5

Names: olfactory receptor 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008763.2 → NP_032789.1 olfactory receptor 10J5

See identical proteins and their annotated locations for NP_032789.1

Status: VALIDATED

Source sequence(s)

AC167961

Consensus CDS

CCDS15521.1

UniProtKB/Swiss-Prot

Q62007

UniProtKB/TrEMBL

Q8VES0

Related

ENSMUSP00000041524.5, ENSMUST00000038432.7

Conserved Domains (2) summary

pfam00001
Location:41 → 289

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:31 → 303

7tm_4; Olfactory receptor