APC APC regulator of WNT signaling pathway [Sus scrofa (pig)] - Gene

Summary

Official Symbol: APCprovided by VGNC
Official Full Name: APC regulator of WNT signaling pathwayprovided by VGNC
Primary source: VGNC:VGNC:99584
See related: Ensembl:ENSSSCG00000014207
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: APC1
Expression: Ubiquitous expression in mixtures (RPKM 10.1), lung (RPKM 8.9) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	2	NC_010444.4 (116913354..116985303, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	2	NC_010444.3 (121515522..121573844)

Chromosome 2 - NC_010444.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables beta-catenin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables gamma-catenin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables microtubule binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell fate specification	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of microtubule depolymerization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in pattern specification process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of beta-catenin destruction complex	IEA Inferred from Electronic Annotation more info	PubMed
part_of catenin complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytoplasmic microtubule	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: adenomatous polyposis coli protein

Names: APC, WNT signaling pathway regulator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001206430.1 → NP_001193359.1 adenomatous polyposis coli protein

See identical proteins and their annotated locations for NP_001193359.1

Status: PROVISIONAL

Source sequence(s)

HQ288551

UniProtKB/TrEMBL

A0A8D0KFK7, A0A8D2BDF5, F2X0U8

Related

ENSSSCP00000034637.3, ENSSSCT00000057845.3

Conserved Domains (14) summary

cd00020
Location:611 → 731

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam05923
Location:1640 → 1664

APC_crr; APC cysteine-rich region

pfam05924
Location:2038 → 2057

SAMP; SAMP Motif

pfam05937
Location:2674 → 2847

EB1_binding; EB-1 Binding Domain

pfam05956
Location:2227 → 2572

APC_basic; APC basic domain

pfam11414
Location:133 → 207

Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein

pfam16629
Location:732 → 1019

Arm_APC_u3; Armadillo-associated region on APC

pfam16630
Location:1036 → 1135

APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs

pfam16633
Location:1285 → 1370

APC_u9; Unstructured region on APC between 1st two creatine-rich regions

pfam16634
Location:1665 → 1721

APC_u13; Unstructured region on APC between APC_crr and SAMP

pfam16635
Location:1742 → 1842

APC_u14; Unstructured region on APC between SAMP and APC_crr

pfam16636
Location:1879 → 1950

APC_u15; Unstructured region on APC between APC_crr regions 5 and 6

pfam16689
Location:4 → 55

APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

sd00043
Location:563 → 595

ARM; armadillo repeat [structural motif]