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    BET5 TRAPP subunit BET5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854898, updated on 19-Jun-2024

    Summary

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    Gene symbol
    BET5
    Gene description
    TRAPP subunit BET5
    Primary source
    FungiDB:YML077W
    Locus tag
    YML077W
    See related
    SGD:S000004542; AllianceGenome:SGD:S000004542; VEuPathDB:YML077W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to guanyl-nucleotide exchange factor activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Part of TRAPPI protein complex; TRAPPII protein complex; and TRAPPIII protein complex. Used to study cancer and melanoma. Orthologous to human TRAPPC1 (trafficking protein particle complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See BET5 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (111865..112344)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Cff1p Neighboring gene peptidylprolyl isomerase CPR3 Neighboring gene War1p Neighboring gene hydroxymethylglutaryl-CoA reductase (NADPH) HMG1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification of TRAPP from Saccharomyces cerevisiae and identification of its mammalian counterpart. Sacher M, et al. Methods Enzymol, 2001. PMID 11210539
    2. Two antigens recognized by autologous cytolytic T lymphocytes on a melanoma result from a single point mutation in an essential housekeeping gene. Chiari R, et al. Cancer Res, 1999 Nov 15. PMID 10582700
    3. Yeast rab GTPase-activating protein Gyp1p localizes to the Golgi apparatus and is a negative regulator of Ypt1p. Du LL, et al. Mol Biol Cell, 2001 May. PMID 11359917, Free PMC Article
    4. Trs33-Containing TRAPP IV: A Novel Autophagy-Specific Ypt1 GEF. Lipatova Z, et al. Genetics, 2016 Nov. PMID 27672095, Free PMC Article
    5. TRAPPI tethers COPII vesicles by binding the coat subunit Sec23. Cai H, et al. Nature, 2007 Feb 22. PMID 17287728

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to guanyl-nucleotide exchange factor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    contributes_to guanyl-nucleotide exchange factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi vesicle transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of TRAPP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TRAPP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of TRAPPI protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of TRAPPII protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of TRAPPIII protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in phagophore assembly site IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TRAPP subunit BET5
    NP_013634.1
    • Core component of transport protein particle (TRAPP) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factors for the GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII); human homology TRAPPC1 complements yeast null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      111865..112344
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182436.1 → NP_013634.1  TPA: TRAPP subunit BET5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013634.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0K6, Q03630
      UniProtKB/TrEMBL
      A0A6A5PSF0, A6ZLY8, B3LLH9, C7GW12, C8ZEC8, G2WJX8, N1P656
      Conserved Domains (1) summary
      cd14855
      Location:4 → 152
      TRAPPC1_MUM2; Trafficking protein particle complex subunit 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03630.1

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