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    yars1 tyrosyl-tRNA synthetase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 368235, updated on 2-Nov-2024

    Summary

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    Official Symbol
    yars1provided by ZNC
    Official Full Name
    tyrosyl-tRNA synthetase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030425-2
    See related
    Ensembl:ENSDARG00000035913 AllianceGenome:ZFIN:ZDB-GENE-030425-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    yars; cb204; wu:fk52b08
    Summary
    Predicted to enable tyrosine-tRNA ligase activity. Acts upstream of or within DNA damage response. Predicted to be located in nucleus. Is expressed in several structures, including digestive system; hematopoietic system; immature eye; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate C. Orthologous to human YARS1 (tyrosyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See yars1 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (30884966..30895274)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (31297641..31307961)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene MYCL proto-oncogene, bHLH transcription factor b Neighboring gene MFSD2 lysolipid transporter A, lysophospholipid b Neighboring gene NHS like 3 Neighboring gene syncoilin, intermediate filament protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Acetylation promotes TyrRS nuclear translocation to prevent oxidative damage. Cao X, et al. Proc Natl Acad Sci U S A, 2017 Jan 24. PMID 28069943, Free PMC Article
    2. Oxidative stress diverts tRNA synthetase to nucleus for protection against DNA damage. Wei N, et al. Mol Cell, 2014 Oct 23. PMID 25284223, Free PMC Article
    3. Characterization of fibronectin type III domain-containing protein 5 (FNDC5) gene in chickens: Cloning, tissue expression, and regulation of its expression in the muscle by fasting and cold exposure. Li X, et al. Gene, 2015 Oct 10. PMID 26072164
    4. Gnotobiotic zebrafish reveal evolutionarily conserved responses to the gut microbiota. Rawls JF, et al. Proc Natl Acad Sci U S A, 2004 Mar 30. PMID 15070763, Free PMC Article
    5. Systematic expression profiling of neuropathy-related aminoacyl-tRNA synthetases in zebrafish during development. Giong HK, et al. Biochem Biophys Res Commun, 2022 Jan 8. PMID 34872004

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tyrosine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tyrosine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tyrosyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine--tRNA ligase, cytoplasmic
    Names
    tyrRS
    tyrosyl--tRNA ligase
    tyrosyl-tRNA synthetase, cytoplasmic
    NP_958473.1
    XP_005159655.1
    XP_021323679.1
    XP_068071142.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201316.1 → NP_958473.1  tyrosine--tRNA ligase, cytoplasmic

      See identical proteins and their annotated locations for NP_958473.1

      Status: PROVISIONAL

      Source sequence(s)
      AY398430
      UniProtKB/Swiss-Prot
      Q6DFZ7, Q6TGS6
      UniProtKB/TrEMBL
      A0A0R4I9C1, A0A8M9PG97
      Related
      ENSDARP00000052125.2, ENSDART00000052126.4
      Conserved Domains (2) summary
      cl00015
      Location:8 → 336
      nt_trans; nucleotidyl transferase superfamily
      cl26127
      Location:293 → 529
      PRK12267; methionyl-tRNA synthetase; Reviewed

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      30884966..30895274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005159598.5 → XP_005159655.1  tyrosine--tRNA ligase, cytoplasmic isoform X1

      See identical proteins and their annotated locations for XP_005159655.1

      UniProtKB/Swiss-Prot
      Q6DFZ7, Q6TGS6
      UniProtKB/TrEMBL
      A0A0R4I9C1, A0A8M9PG97
      Related
      ENSDARP00000144984.1, ENSDART00000183224.1
      Conserved Domains (2) summary
      cl00015
      Location:8 → 336
      nt_trans; nucleotidyl transferase superfamily
      cl26127
      Location:293 → 529
      PRK12267; methionyl-tRNA synthetase; Reviewed

    2. XM_068215041.1 → XP_068071142.1  tyrosine--tRNA ligase, cytoplasmic isoform X1

    3. XM_021468004.2 → XP_021323679.1  tyrosine--tRNA ligase, cytoplasmic isoform X1

      UniProtKB/Swiss-Prot
      Q6DFZ7, Q6TGS6
      UniProtKB/TrEMBL
      A0A0R4I9C1, A0A8M9PG97
      Conserved Domains (2) summary
      cl00015
      Location:8 → 336
      nt_trans; nucleotidyl transferase superfamily
      cl26127
      Location:293 → 529
      PRK12267; methionyl-tRNA synthetase; Reviewed

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395051.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      181732..192036
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6TGS6.2 GenPept UniProtKB/Swiss-Prot:Q6TGS6

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