PAPOLB poly(A) polymerase beta [Homo sapiens (human)] - Gene

Summary

Official Symbol: PAPOLBprovided by HGNC
Official Full Name: poly(A) polymerase betaprovided by HGNC
Primary source: HGNC:HGNC:15970
See related: Ensembl:ENSG00000218823 MIM:607436; AllianceGenome:HGNC:15970
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PAPT; TPAP
Summary: Predicted to enable poly(A) RNA polymerase activity. Predicted to be involved in RNA 3'-end processing and mRNA processing. Predicted to be located in endoplasmic reticulum. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: mouse all
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Genomic context

Location:: 7p22.1

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (4857738..4862030, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (4974940..4979232, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (4897369..4901661, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	The poly(A) site in the HIV-1 5'-LTR is occluded in a Tat-dependent manner, suggesting a role for Tat in regulating this nucleotide signal	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables poly(A) RNA polymerase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in RNA 3'-end processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: poly(A) polymerase beta

Names: PAP-beta; poly(A) polymerase beta (testis specific); polynucleotide adenylyltransferase beta; testis-specific poly(A) polymerase

NP_064529.4

EC 2.7.7.19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020144.5 → NP_064529.4 poly(A) polymerase beta

See identical proteins and their annotated locations for NP_064529.4

Status: VALIDATED

Source sequence(s)

AC092610, AF218840, BC036653

Consensus CDS

CCDS78202.1

UniProtKB/Swiss-Prot

Q75LH1, Q8NE14, Q9NRJ5

UniProtKB/TrEMBL

A0ZTA0, A4D1Z6

Related

ENSP00000384700.2, ENST00000404991.2

Conserved Domains (3) summary

PTZ00418
Location:21 → 569

PTZ00418; Poly(A) polymerase; Provisional

pfam04926
Location:367 → 496

PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain

pfam04928
Location:22 → 364

PAP_central; Poly(A) polymerase central domain