Mafg v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mafgprovided by MGI
Official Full Name: v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)provided by MGI
Primary source: MGI:MGI:96911
See related: Ensembl:ENSMUSG00000051510 AllianceGenome:MGI:96911
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C630022N07Rik
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of gene expression and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including adult behavior; in utero embryonic development; and regulation of epidermal cell differentiation. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human MAFG (MAF bZIP transcription factor G). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 18.1), adrenal adult (RPKM 17.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 84.35 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (120515943..120525771, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (120625117..120634955, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of HMOX1 by MAFG potentiates the development of depression-like behavior in mice associated with astrocyte-mediated neuroinflammation.
Title: Inhibition of HMOX1 by MAFG potentiates the development of depression‑like behavior in mice associated with astrocyte-mediated neuroinflammation.
Silencing Mafg in mouse hepatocytes and obese mice elicits a fasting-like gene expression profile, improves glucose metabolism.
Title: A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism.
results provide direct evidence that the Nrf2-MafG heterodimer acts as a transcriptional activator of Nrf2-dependent genes
Title: Direct and Specific Functional Evaluation of the Nrf2 and MafG Heterodimer by Introducing a Tethered Dimer into Small Maf-Deficient Cells.
In condition of hypoxia, MAFG induction correlated with reduced levels of miR-128. This lead to increased mRNA levels of HMOX-1 and x-CT for blunting stress. Overall, these findings identify MAFG as novel direct target of miR-128.
Title: miR-128 Is Implicated in Stress Responses by Targeting MAFG in Skeletal Muscle Cells.
The CNC-sMaf binding element is strictly required for the Nrf2-sMaf heterodimer function in cytoprotection.
Title: Unique cistrome defined as CsMBE is strictly required for Nrf2-sMaf heterodimer function in cytoprotection.
The MafG as an FXR target gene and show that hepatic MAFG expression represses genes of the bile acid synthetic pathway and modifies the biliary bile acid composition.
Title: MAFG is a transcriptional repressor of bile acid synthesis and metabolism.
These data identify Mafg and Mafk as new cataract-associated candidates and define their function in regulating largely non-crystallin genes linked to human cataract.
Title: Compound mouse mutants of bZIP transcription factors Mafg and Mafk reveal a regulatory network of non-crystallin genes associated with cataract.
These findings demonstrate that a combination of p45NF-E2, Maf G, and Maf K is a key determinant of both megakaryopoiesis and thrombopoiesis.
Title: Induction of functional platelets from mouse and human fibroblasts by p45NF-E2/Maf.
MafF, MafG, and MafK triple-knockout mice developed normally until embryonic day 9.5 (E9.5). Thereafter, however, the triple-knockout embryos showed severe growth retardation and liver hypoplasia, and the embryos died around E13.5.
Title: Embryonic lethality and fetal liver apoptosis in mice lacking all three small Maf proteins.
The MafG C terminus is essential for proplatelet formation and platelet gene activation but not for p45 binding to the Maf recognition element (MARE).
Title: Molecular determinants for small Maf protein control of platelet production.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Mafg (e-PCR), detects polymorphism
- UniSTS:274181

Mafg (e-PCR), detects polymorphism
- UniSTS:257104

RH124317 (e-PCR)
- UniSTS:161139

PMC305674P1 (e-PCR)
- UniSTS:272556

Mafg (e-PCR), detects polymorphism
- UniSTS:547259

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cellular pH	ISO Inferred from Sequence Orthology more info
involved_in regulation of epidermal cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of epidermal cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: transcription factor MafG

Names: V-maf musculoaponeurotic fibrosarcoma oncogene homolog G; avian musculoaponeurotic fibrosarcoma virus (v-maf) AS42 oncogene, protein G

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010756.3 → NP_034886.1 transcription factor MafG

See identical proteins and their annotated locations for NP_034886.1

Status: VALIDATED

Source sequence(s)

BC052633

Consensus CDS

CCDS25748.1

UniProtKB/Swiss-Prot

O54790

Related

ENSMUSP00000053899.8, ENSMUST00000058162.14

Conserved Domains (1) summary

cd14717
Location:46 → 115

bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

120515943..120525771 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245626.2 → XP_030101486.1 transcription factor MafG isoform X2

UniProtKB/Swiss-Prot

O54790

Conserved Domains (1) summary

cd14717
Location:46 → 115

bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
XM_030245627.2 → XP_030101487.1 transcription factor MafG isoform X2

UniProtKB/Swiss-Prot

O54790

Conserved Domains (1) summary

cd14717
Location:46 → 115

bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
XM_017314308.3 → XP_017169797.1 transcription factor MafG isoform X2

UniProtKB/Swiss-Prot

O54790

Related

ENSMUSP00000101788.2, ENSMUST00000106182.8

Conserved Domains (1) summary

cd14717
Location:46 → 115

bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
XM_036156373.1 → XP_036012266.1 transcription factor MafG isoform X2

UniProtKB/Swiss-Prot

O54790

Conserved Domains (1) summary

cd14717
Location:46 → 115

bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
XM_017314307.2 → XP_017169796.1 transcription factor MafG isoform X1

Conserved Domains (1) summary

cd14717
Location:103 → 172

bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
XM_017314309.2 → XP_017169798.1 transcription factor MafG isoform X2

UniProtKB/Swiss-Prot

O54790

Related

ENSMUSP00000101787.2, ENSMUST00000106181.8

Conserved Domains (1) summary

cd14717
Location:46 → 115

bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
XM_017314311.3 → XP_017169800.1 transcription factor MafG isoform X2

UniProtKB/Swiss-Prot

O54790

Conserved Domains (1) summary

cd14717
Location:46 → 115

bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain