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    FOXP1 forkhead box P1 [ Homo sapiens (human) ]

    Gene ID: 27086, updated on 27-Nov-2024

    Summary

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    Official Symbol
    FOXP1provided by HGNC
    Official Full Name
    forkhead box P1provided by HGNC
    Primary source
    HGNC:HGNC:3823
    See related
    Ensembl:ENSG00000114861 MIM:605515; AllianceGenome:HGNC:3823
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MFH; QRF1; 12CC4; hFKH1B; HSPC215
    Summary
    This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lung (RPKM 7.3), ovary (RPKM 7.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FOXP1 in Genome Data Viewer
    Location:
    3p13
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (70954708..71583978, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (70991208..71623253, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (71003859..71633129, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr3:70838694-70838912 Neighboring gene high mobility group box 1 pseudogene 36 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:70882268-70882846 Neighboring gene RNA, U6 small nuclear 281, pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:70902705-70903904 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:70903859-70904359 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:70926235-70926734 Neighboring gene OCT4 hESC enhancer GRCh37_chr3:70976354-70976889 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:70998543-70998739 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:71012492-71013094 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:71025197-71026396 Neighboring gene VISTA enhancer hs864 Neighboring gene VISTA enhancer hs965 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:71114251-71114751 Neighboring gene uncharacterized LOC124906247 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr3:71128185-71128767 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20059 Neighboring gene VISTA enhancer hs1092 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:71178876-71179618 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:71193639-71194138 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:71205831-71206536 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:71214878-71215027 Neighboring gene NANOG hESC enhancer GRCh37_chr3:71259322-71259867 Neighboring gene VISTA enhancer hs630 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:71275618-71276118 Neighboring gene VISTA enhancer hs187 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:71354949-71355604 Neighboring gene FOXP1 antisense RNA 1 Neighboring gene uncharacterized LOC124906248 Neighboring gene Sharpr-MPRA regulatory region 6361 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20060 Neighboring gene VISTA enhancer hs1116 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:71463501-71464005 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20061 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20062 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20063 Neighboring gene Sharpr-MPRA regulatory region 10822 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:71546600-71547538 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:71552767-71553966 Neighboring gene Sharpr-MPRA regulatory region 15380 Neighboring gene VISTA enhancer hs1149 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14520 Neighboring gene Sharpr-MPRA regulatory region 11865 Neighboring gene microRNA 1284 Neighboring gene uncharacterized LOC105377155 Neighboring gene FOXP1 divergent transcript

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. FOXP1 haploinsufficiency: Phenotypes beyond behavior and intellectual disability? Myers A, et al. Am J Med Genet A, 2017 Dec. PMID 28884888
    2. FOXP1 expression in monoclonal gammopathy of undetermined significance and multiple myeloma. Korać P, et al. Pathol Int, 2009 May. PMID 19432679
    3. FOXP1 functions as an oncogene in promoting cancer stem cell-like characteristics in ovarian cancer cells. Choi EJ, et al. Oncotarget, 2016 Jan 19. PMID 26654944, Free PMC Article
    4. Subtype-specific addiction of the activated B-cell subset of diffuse large B-cell lymphoma to FOXP1. Dekker JD, et al. Proc Natl Acad Sci U S A, 2016 Feb 2. PMID 26787899, Free PMC Article
    5. FOXP1 Expression in Normal and Neoplastic Erythroid and Myeloid Cells. Lovrić E, et al. Coll Antropol, 2015 Sep. PMID 26898077

    See all (255) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A novel protein encoded by circFOXP1 enhances ferroptosis and inhibits tumor recurrence in intrahepatic cholangiocarcinoma.
      Title: A novel protein encoded by circFOXP1 enhances ferroptosis and inhibits tumor recurrence in intrahepatic cholangiocarcinoma.
    2. Spatiotemporal transcriptomic changes of human ovarian aging and the regulatory role of FOXP1.
      Title: Spatiotemporal transcriptomic changes of human ovarian aging and the regulatory role of FOXP1.
    3. The role of transcription factor FOXA1/C2/M1/O3/P1/Q1 in breast cancer.
      Title: The role of transcription factor FOXA1/C2/M1/O3/P1/Q1 in breast cancer.
    4. NAT10/ac4C/FOXP1 Promotes Malignant Progression and Facilitates Immunosuppression by Reprogramming Glycolytic Metabolism in Cervical Cancer.
      Title: NAT10/ac4C/FOXP1 Promotes Malignant Progression and Facilitates Immunosuppression by Reprogramming Glycolytic Metabolism in Cervical Cancer.
    5. FOXP1 orchestrates neurogenesis in human cortical basal radial glial cells.
      Title: FOXP1 orchestrates neurogenesis in human cortical basal radial glial cells.
    6. Deacetylation of FOXP1 by HDAC7 potentiates self-renewal of mesenchymal stem cells.
      Title: Deacetylation of FOXP1 by HDAC7 potentiates self-renewal of mesenchymal stem cells.
    7. miR-526b-5p/c-Myc/Foxp1 participates in recurrent spontaneous abortion by regulating the proliferation, migration, and invasion of trophoblasts.
      Title: miR-526b-5p/c-Myc/Foxp1 participates in recurrent spontaneous abortion by regulating the proliferation, migration, and invasion of trophoblasts.
    8. Single-nucleus transcriptomics reveals a gatekeeper role for FOXP1 in primate cardiac aging.
      Title: Single-nucleus transcriptomics reveals a gatekeeper role for FOXP1 in primate cardiac aging.
    9. FOXP1 inhibits pancreatic cancer growth by transcriptionally regulating IRF1 expression.
      Title: FOXP1 inhibits pancreatic cancer growth by transcriptionally regulating IRF1 expression.
    10. Transcription factor FOXP1 mediates vascular endothelial dysfunction in diabetic retinopathy.
      Title: Transcription factor FOXP1 mediates vascular endothelial dysfunction in diabetic retinopathy.
    Submit: New GeneRIF Correction See all GeneRIFs (187)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2020-01-22)

    ClinGen Genome Curation Page
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated 2020-01-22)

    ClinGen Genome Curation PagePubMed

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus.
    EBI GWAS Catalog
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog
    Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations.
    EBI GWAS Catalog
    Genome-wide association study and meta-analysis of intraocular pressure.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies new susceptibility loci for migraine.
    EBI GWAS Catalog
    Impact of ancestry and common genetic variants on QT interval in African Americans.
    EBI GWAS Catalog
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ23741, MGC12942, MGC88572, MGC99551

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables core promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear androgen receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in T follicular helper cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endothelial cell activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in macrophage activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monocyte activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of B cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of androgen receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cell growth involved in cardiac muscle cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in osteoclast development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in osteoclast differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of B cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of hydrogen peroxide-mediated programmed cell death IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of interleukin-21 production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of chemokine (C-X-C motif) ligand 2 production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of defense response to bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of endothelial tube morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of inflammatory response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of interleukin-1 beta production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of interleukin-12 production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of macrophage colony-stimulating factor production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of monocyte differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to testosterone IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in striatum development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    forkhead box protein P1
    Names
    fork head-related protein like B
    glutamine-rich factor 1
    mac-1-regulated forkhead

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028243.1 RefSeqGene

      Range
      5262..634282
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001012505.2 → NP_001012523.1  forkhead box protein P1 isoform b

      See identical proteins and their annotated locations for NP_001012523.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks multiple 3' exons but has an alternate exon in the 3' end, compared to variant 1. The encoded isoform b (previously called isoform 2) has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC097634, BC005055, BC068481
      Consensus CDS
      CCDS33785.1
      UniProtKB/Swiss-Prot
      Q9H334
      Related
      ENSP00000318721.3, ENST00000318779.7

    2. NM_001244808.3 → NP_001231737.1  forkhead box protein P1 isoform c

      See identical proteins and their annotated locations for NP_001231737.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (c, previously called 3) has the same N- and C-termini but is 1 aa shorter compared to isoform a.
      Source sequence(s)
      AC103586, AK122710, BC068481, GD144178
      Consensus CDS
      CCDS58839.1
      UniProtKB/TrEMBL
      Q8TEA2
      Related
      ENSP00000418524.1, ENST00000493089.7
      Conserved Domains (3) summary
      COG5025
      Location:437 → 650
      COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
      pfam16159
      Location:302 → 369
      FOXP-CC; FOXP coiled-coil domain
      cd20065
      Location:463 → 544
      FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

    3. NM_001244810.2 → NP_001231739.1  forkhead box protein P1 isoform d

      See identical proteins and their annotated locations for NP_001231739.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon but contains another compared to variant 1. The resulting isoform (d, previously called 4) has the same N- and C-termini but is longer compared to isoform a. This variant encodes the longest isoform, which has been shown to enhance embryonic stem (ES) cell pluripotency and repress ES cell differentiation.
      Source sequence(s)
      AC097634, AC103586, AK122710, BC054505, BC068481, GD144178
      Consensus CDS
      CCDS74964.1
      UniProtKB/TrEMBL
      Q8TEA2
      Related
      ENSP00000498110.1, ENST00000648426.1
      Conserved Domains (2) summary
      pfam16159
      Location:302 → 369
      FOXP-CC; FOXP coiled-coil domain
      cl00061
      Location:464 → 545
      FH_FOX; Forkhead (FH) domain found in Forkhead box (FOX) family of transcription factors and similar proteins

    4. NM_001244812.3 → NP_001231741.1  forkhead box protein P1 isoform e

      See identical proteins and their annotated locations for NP_001231741.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate in-frame segment compared to variant 1. The resulting isoform (e, previously called 5) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AA380962, AC103586, AC104442, AK092383, GD144178
      Consensus CDS
      CCDS58838.1
      UniProtKB/TrEMBL
      Q8TEA2
      Related
      ENSP00000417857.1, ENST00000484350.5
      Conserved Domains (3) summary
      COG5025
      Location:361 → 575
      COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
      pfam16159
      Location:226 → 293
      FOXP-CC; FOXP coiled-coil domain
      cd20065
      Location:388 → 469
      FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

    5. NM_001244813.3 → NP_001231742.1  forkhead box protein P1 isoform f

      See identical proteins and their annotated locations for NP_001231742.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (f, previously called 6) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AC097632, AC103586, AK074569, GD144178
      Consensus CDS
      CCDS74963.1
      UniProtKB/TrEMBL
      A0A3B3IT66, B4DMV4
      Related
      ENSP00000497567.1, ENST00000650387.1
      Conserved Domains (3) summary
      COG5025
      Location:337 → 551
      COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
      pfam16159
      Location:202 → 269
      FOXP-CC; FOXP coiled-coil domain
      cd20065
      Location:364 → 445
      FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

    6. NM_001244814.3 → NP_001231743.1  forkhead box protein P1 isoform a

      See identical proteins and their annotated locations for NP_001231743.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1, 7, 9, 11 and 13 all encode the same isoform (a).
      Source sequence(s)
      AC097632, AC103586, AK074321, DA518749, GD144178
      Consensus CDS
      CCDS2914.1
      UniProtKB/Swiss-Prot
      A3QVP8, B3KV70, G5E9V8, Q8NAN6, Q9BSG9, Q9H332, Q9H333, Q9H334, Q9P0R1
      UniProtKB/TrEMBL
      A0A024R346, Q548T7, Q8TEA2
      Related
      ENSP00000418102.1, ENST00000498215.7
      Conserved Domains (3) summary
      COG5025
      Location:437 → 651
      COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
      pfam16159
      Location:302 → 369
      FOXP-CC; FOXP coiled-coil domain
      cd20065
      Location:464 → 545
      FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

    7. NM_001244815.2 → NP_001231744.2  forkhead box protein P1 isoform f

      Status: REVIEWED

      Source sequence(s)
      AC103586, AK027264, DA634017, GD144178
      Consensus CDS
      CCDS74963.1
      UniProtKB/TrEMBL
      A0A3B3IT66, B4DMV4
      Related
      ENSP00000497077.3, ENST00000648748.3
      Conserved Domains (3) summary
      COG5025
      Location:337 → 551
      COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
      pfam16159
      Location:202 → 269
      FOXP-CC; FOXP coiled-coil domain
      cd20065
      Location:364 → 445
      FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

    8. NM_001244816.2 → NP_001231745.1  forkhead box protein P1 isoform a

      See identical proteins and their annotated locations for NP_001231745.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1, 7, 9, 11 and 13 all encode the same isoform (a).
      Source sequence(s)
      AC103586, AF250920, GD144178
      Consensus CDS
      CCDS2914.1
      UniProtKB/Swiss-Prot
      A3QVP8, B3KV70, G5E9V8, Q8NAN6, Q9BSG9, Q9H332, Q9H333, Q9H334, Q9P0R1
      UniProtKB/TrEMBL
      A0A024R346, Q548T7, Q8TEA2
      Related
      ENSP00000497344.1, ENST00000648380.1
      Conserved Domains (3) summary
      COG5025
      Location:437 → 651
      COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
      pfam16159
      Location:302 → 369
      FOXP-CC; FOXP coiled-coil domain
      cd20065
      Location:464 → 545
      FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

    9. NM_001349337.2 → NP_001336266.2  forkhead box protein P1 isoform i

      Status: REVIEWED

      Source sequence(s)
      AC097632, AC103586
      Consensus CDS
      CCDS93310.1
      UniProtKB/TrEMBL
      A0A0B4J2F3, A0A5H1ZRR8, B4DMV4
      Related
      ENSP00000420736.3, ENST00000491238.8
      Conserved Domains (3) summary
      COG5025
      Location:336 → 550
      COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
      pfam16159
      Location:201 → 268
      FOXP-CC; FOXP coiled-coil domain
      cd20065
      Location:363 → 444
      FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

    10. NM_001349338.3 → NP_001336267.1  forkhead box protein P1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variants 1, 7, 9, and 13, encodes isoform a.
      Source sequence(s)
      AC097632, AC097634, AC103586, AC104442, AC104645, AC138058
      Consensus CDS
      CCDS2914.1
      UniProtKB/Swiss-Prot
      A3QVP8, B3KV70, G5E9V8, Q8NAN6, Q9BSG9, Q9H332, Q9H333, Q9H334, Q9P0R1
      UniProtKB/TrEMBL
      A0A024R346, Q548T7, Q8TEA2
      Related
      ENSP00000497369.1, ENST00000649528.3
      Conserved Domains (3) summary
      COG5025
      Location:437 → 651
      COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
      pfam16159
      Location:302 → 369
      FOXP-CC; FOXP coiled-coil domain
      cd20065
      Location:464 → 545
      FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

    11. NM_001349340.3 → NP_001336269.1  forkhead box protein P1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variants 1, 7, 9, and 11 encodes isoform a.
      Source sequence(s)
      AC097632, AC097634, AC103586, AC104442, AC104645, AC138058
      Consensus CDS
      CCDS2914.1
      UniProtKB/Swiss-Prot
      A3QVP8, B3KV70, G5E9V8, Q8NAN6, Q9BSG9, Q9H332, Q9H333, Q9H334, Q9P0R1
      UniProtKB/TrEMBL
      A0A024R346, Q548T7, Q8TEA2
      Related
      ENSP00000496990.1, ENST00000649631.1
      Conserved Domains (3) summary
      COG5025
      Location:437 → 651
      COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
      pfam16159
      Location:302 → 369
      FOXP-CC; FOXP coiled-coil domain
      cd20065
      Location:464 → 545
      FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

    12. NM_001349341.3 → NP_001336270.1  forkhead box protein P1 isoform j

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) encodes isoform j.
      Source sequence(s)
      AC097632, AC097634, AC103586, AC104442, AC104645, AC138058
      Consensus CDS
      CCDS93312.1
      UniProtKB/TrEMBL
      A0A3B3IST0, Q8TEA2
      Related
      ENSP00000497693.2, ENST00000649610.2
      Conserved Domains (3) summary
      COG5025
      Location:436 → 650
      COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
      pfam16159
      Location:301 → 368
      FOXP-CC; FOXP coiled-coil domain
      cd20065
      Location:463 → 544
      FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

    13. NM_001349342.3 → NP_001336271.1  forkhead box protein P1 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variant 6, encodes isoform f.
      Source sequence(s)
      AC097632, AC103586
      Consensus CDS
      CCDS74963.1
      UniProtKB/TrEMBL
      A0A3B3IT66, B4DMV4
      Related
      ENSP00000496968.1, ENST00000649592.1
      Conserved Domains (3) summary
      COG5025
      Location:337 → 551
      COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
      pfam16159
      Location:202 → 269
      FOXP-CC; FOXP coiled-coil domain
      cd20065
      Location:364 → 445
      FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

    14. NM_001349343.3 → NP_001336272.1  forkhead box protein P1 isoform i

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variant 17, encodes isoform i.
      Source sequence(s)
      AC097632, AC103586
      Consensus CDS
      CCDS93310.1
      UniProtKB/TrEMBL
      A0A0B4J2F3, A0A5H1ZRR8, B4DMV4
      Related
      ENSP00000497435.1, ENST00000648794.2
      Conserved Domains (3) summary
      COG5025
      Location:336 → 550
      COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
      pfam16159
      Location:201 → 268
      FOXP-CC; FOXP coiled-coil domain
      cd20065
      Location:363 → 444
      FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

    15. NM_001349344.3 → NP_001336273.1  forkhead box protein P1 isoform i

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variant 16, encodes isoform i.
      Source sequence(s)
      AC097632, AC103586
      Consensus CDS
      CCDS93310.1
      UniProtKB/TrEMBL
      A0A0B4J2F3, A0A5H1ZRR8, B4DMV4
      Related
      ENSP00000482847.2, ENST00000614176.5
      Conserved Domains (3) summary
      COG5025
      Location:336 → 550
      COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
      pfam16159
      Location:201 → 268
      FOXP-CC; FOXP coiled-coil domain
      cd20065
      Location:363 → 444
      FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

    16. NM_001370548.1 → NP_001357477.1  forkhead box protein P1 isoform k

      Status: REVIEWED

      Source sequence(s)
      AC097632, AC103586
      Consensus CDS
      CCDS93311.1
      UniProtKB/TrEMBL
      A0A3B3IRW5, A0A3B3IS20, B4DMV4
      Related
      ENSP00000496841.3, ENST00000649695.3
      Conserved Domains (3) summary
      COG5025
      Location:337 → 550
      COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
      pfam16159
      Location:202 → 269
      FOXP-CC; FOXP coiled-coil domain
      cd20065
      Location:363 → 444
      FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

    17. NM_032682.6 → NP_116071.2  forkhead box protein P1 isoform a

      See identical proteins and their annotated locations for NP_116071.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform a (previously called isoform 1). Variants 1, 7, 9, 11 and 13 all encode the same isoform (a).
      Source sequence(s)
      AC097634, AC103586, AK122710, BC068481
      Consensus CDS
      CCDS2914.1
      UniProtKB/Swiss-Prot
      A3QVP8, B3KV70, G5E9V8, Q8NAN6, Q9BSG9, Q9H332, Q9H333, Q9H334, Q9P0R1
      UniProtKB/TrEMBL
      A0A024R346, Q548T7, Q8TEA2
      Related
      ENSP00000318902.5, ENST00000318789.11
      Conserved Domains (3) summary
      COG5025
      Location:437 → 651
      COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
      pfam16159
      Location:302 → 369
      FOXP-CC; FOXP coiled-coil domain
      cd20065
      Location:464 → 545
      FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

    RNA

    1. NR_146142.3 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC097632, AC097634, AC103586, AC104442, AC104645, AC138058

    2. NR_146143.3 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC097632, AC097634, AC103586, AC104442, AC104645, AC138058

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      70954708..71583978 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      70991208..71623253 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H334.1 GenPept UniProtKB/Swiss-Prot:Q9H334

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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