GLG1 golgi glycoprotein 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GLG1provided by HGNC
Official Full Name: golgi glycoprotein 1provided by HGNC
Primary source: HGNC:HGNC:4316
See related: Ensembl:ENSG00000090863 MIM:600753; AllianceGenome:HGNC:4316
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CFR-1; ESL-1; MG160; MG-160
Summary: Predicted to enable fibroblast growth factor binding activity. Predicted to act upstream of or within several processes, including negative regulation of protein processing; negative regulation of transforming growth factor beta receptor signaling pathway; and regulation of chondrocyte differentiation. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in ovary (RPKM 26.0), testis (RPKM 23.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16q23.1

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (74447440..74607114, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (80494088..80653847, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (74481338..74641012, complement)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study identifies NRP2 and ESL-1 as targets for polysialylation in murine microglia and human THP-1 macrophages and reveals a striking convergence in the regulation of the two polysialylated acceptors in the course of inflammatory activation. A pool of polysialylated NRP2 and ESL-1 is assembled after injury or in culture and its shedding is an early response to lipopolysaccharide-induced activation of microglia.
Title: Polysialylation and lipopolysaccharide-induced shedding of E-selectin ligand-1 and neuropilin-2 by microglia and THP-1 macrophages.
Our results highlight the fact that interaction between APN and ESL-1 could provide a fundamental mechanism underlying the anti-atherogenic properties of APN.
Title: E-selectin ligand-1 (ESL-1) is a novel adiponectin binding protein on cell adhesion.
circulating prostate cancer cells' rolling capacity contributes to metastasis, and that is in part controlled by ESL-1.
Title: E-selectin ligand-1 controls circulating prostate cancer cell rolling/adhesion and metastasis.
Studies indicate that PSGL-1, CD44, and ESL-1 on mature leukocytes are physiologic glycoprotein ligands for endothelial P-selectin and E-selectin.
Title: Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow.
expression of Cfr in the Golgi apparatus and on the plasma membrane is finely tuned through two distinct mechanisms for exhibiting different functions.
Title: Retention in the Golgi apparatus and expression on the cell surface of Cfr/Esl-1/Glg-1/MG-160 are regulated by two distinct mechanisms.
C2GnT1 gene expression and the resulting C2-O-sLe(X) carbohydrates produced mediate the adhesive and invasive behaviors of human carcinomas which may influence their metastatic potential.
Title: C2-O-sLeX glycoproteins are E-selectin ligands that regulate invasion of human colon and hepatic carcinoma cells.
Observational study of gene-disease association. (HuGE Navigator)
Title: Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects.
Genome-wide association study of gene-disease association. (HuGE Navigator)
Title: A pilot genome-wide association study of early-onset breast cancer.
under hypoxia, ESL-1 is shed from activated hepatic stellate cells
Title: Expression of E-selectin ligand-1 (CFR/ESL-1) on hepatic stellate cells: implications for leukocyte extravasation and liver metastasis.
evaluated in human brain tumors exhibiting varying degrees of malignancy
Title: Identification of MG-160, a FGF binding medial Golgi sialoglycoprotein, in brain tumors: an index of malignancy in astrocytomas.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A pilot genome-wide association study of early-onset breast cancer. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis identifies four new loci associated with testicular germ cell tumor. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp160, precursor	env	HIV-1 gp160 interacts with GLG1; predicted interaction to be within the Golgi	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G35012 (e-PCR)
- UniSTS:30979

RH70589 (e-PCR)
- UniSTS:12550

SHGC-149692 (e-PCR)
- UniSTS:177167

GDB:434012 (e-PCR)
- UniSTS:157204

RH69584 (e-PCR)
- UniSTS:49180

D8S2279 (e-PCR)
- UniSTS:473907

RH67866 (e-PCR)
- UniSTS:74838

RH70747 (e-PCR)
- UniSTS:15190

D16S3000E (e-PCR)
- UniSTS:153951

D10S16 (e-PCR)
- UniSTS:155756

D1S1425 (e-PCR)
- UniSTS:149621

D16S3115 (e-PCR), detects polymorphism
- UniSTS:51833

SGC33788 (e-PCR)
- UniSTS:46483

SHGC-144852 (e-PCR)
- UniSTS:172460

RH65131 (e-PCR)
- UniSTS:89551

SHGC-32349 (e-PCR)
- UniSTS:495

RH68602 (e-PCR)
- UniSTS:496

RH69504 (e-PCR)
- UniSTS:23804

Clone Names

FLJ23319, FLJ23967, FLJ32797, DKFZp686L08213

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables fibroblast growth factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in bone morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein processing	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in protein processing	IEA Inferred from Electronic Annotation more info
involved_in regulation of chondrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in membrane	HDA more info	PubMed
located_in microtubule organizing center	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: Golgi apparatus protein 1

Names: E-selectin ligand 1; cysteine-rich fibroblast growth factor receptor; golgi sialoglycoprotein MG-160

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145666.2 → NP_001139138.1 Golgi apparatus protein 1 isoform 2 precursor

See identical proteins and their annotated locations for NP_001139138.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.

Source sequence(s)

AC009053, AK304156, BC060822, BX648396, DA493962

Consensus CDS

CCDS45526.1

UniProtKB/Swiss-Prot

Q92896

Related

ENSP00000406946.2, ENST00000447066.6

Conserved Domains (1) summary

pfam00839
Location:789 → 845

Cys_rich_FGFR; Cysteine rich repeat
NM_001145667.2 → NP_001139139.1 Golgi apparatus protein 1 isoform 3 precursor

See identical proteins and their annotated locations for NP_001139139.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) has an additional segment in the 3' region, as compared to variant 1. The resulting isoform (3) is shorter at the C-terminus, as compared to isoform 1.

Source sequence(s)

AC009053, BC060822, BX648396, U64791

Consensus CDS

CCDS45527.1

UniProtKB/Swiss-Prot

B7Z8Y4, D3DUJ7, Q13221, Q6P9D1, Q92896

Related

ENSP00000405984.3, ENST00000422840.7

Conserved Domains (1) summary

pfam00839
Location:800 → 856

Cys_rich_FGFR; Cysteine rich repeat
NM_012201.6 → NP_036333.2 Golgi apparatus protein 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_036333.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC009053, AK304156, BC060822, BX648396

Consensus CDS

CCDS32485.1

UniProtKB/Swiss-Prot

Q92896

Related

ENSP00000205061.5, ENST00000205061.9

Conserved Domains (1) summary

pfam00839
Location:800 → 856

Cys_rich_FGFR; Cysteine rich repeat

RNA

NR_027264.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) has an additional exon in the middle region and an additional segment in the 3' region, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay (NMD) candidate, and is unlikely to make a functional protein.

Source sequence(s)

AC009053, AK027032, AK304156, BX648396, DA493962
NR_027265.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks several internal exons and has an additional segment in the 3' region, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay (NMD) candidate, and is unlikely to make a functional protein.

Source sequence(s)

AC009053, BC031836, BC060822, BX648396, DA493962