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    KLHL25 kelch like family member 25 [ Homo sapiens (human) ]

    Gene ID: 64410, updated on 27-Nov-2024

    Summary

    Official Symbol
    KLHL25provided by HGNC
    Official Full Name
    kelch like family member 25provided by HGNC
    Primary source
    HGNC:HGNC:25732
    See related
    Ensembl:ENSG00000183655 MIM:619893; AllianceGenome:HGNC:25732
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ENC2; ENC-2
    Summary
    Enables ubiquitin-like ligase-substrate adaptor activity. Involved in several processes, including positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; regulation of fatty acid metabolic process; and ubiquitin-dependent protein catabolic process. Located in cytoplasm. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in brain (RPKM 6.7), testis (RPKM 5.6) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See KLHL25 in Genome Data Viewer
    Location:
    15q25.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (85759326..85794925, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (83511457..83547035, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (86302557..86338156, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene A-kinase anchoring protein 13 Neighboring gene Sharpr-MPRA regulatory region 7683 Neighboring gene RNA, U6 small nuclear 1280, pseudogene Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_42301 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_42317 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10018 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10019 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10020 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10021 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10022 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_42385 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6785 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10023 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10024 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr15:86269598-86270797 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:86303833-86304334 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:86305151-86305884 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:86306619-86307352 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:86307353-86308085 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:86311017-86311791 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:86311792-86312565 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:86312566-86313340 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:86313341-86314113 Neighboring gene long intergenic non-protein coding RNA 2883 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:86320779-86321278 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:86332080-86332764 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6787 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6786 Neighboring gene microRNA 1276 Neighboring gene RNA, U6 small nuclear 231, pseudogene Neighboring gene microRNA 548ap

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients.
    EBI GWAS Catalog
    Evidence for shared genetic risk between methamphetamine-induced psychosis and schizophrenia.
    EBI GWAS Catalog
    Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    General protein information

    Preferred Names
    kelch-like protein 25
    Names
    BTB/POZ KELCH domain protein
    ectoderm-neural cortex protein 2
    ectodermal-neural cortex 2
    kelch-like 25

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022480.4NP_071925.2  kelch-like protein 25

      See identical proteins and their annotated locations for NP_071925.2

      Status: VALIDATED

      Source sequence(s)
      AY764034, DA337553, DB063745
      Consensus CDS
      CCDS10339.1
      UniProtKB/Swiss-Prot
      B2RDH2, B3KRT7, Q9H0H3
      UniProtKB/TrEMBL
      B3KPR7
      Related
      ENSP00000336800.5, ENST00000337975.6
      Conserved Domains (4) summary
      PHA03098
      Location:39566
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:330374
      Kelch; KELCH repeat [structural motif]
      cd18254
      Location:24151
      BTB_POZ_KLHL25; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25)
      cd18514
      Location:144242
      BACK_KLHL25_ENC2; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      85759326..85794925 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047432938.1XP_047288894.1  kelch-like protein 25 isoform X1

      UniProtKB/Swiss-Prot
      B2RDH2, B3KRT7, Q9H0H3
    2. XM_047432937.1XP_047288893.1  kelch-like protein 25 isoform X1

      UniProtKB/Swiss-Prot
      B2RDH2, B3KRT7, Q9H0H3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      83511457..83547035 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054378614.1XP_054234589.1  kelch-like protein 25 isoform X2

    2. XM_054378615.1XP_054234590.1  kelch-like protein 25 isoform X1

      UniProtKB/Swiss-Prot
      B2RDH2, B3KRT7, Q9H0H3