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    BPIFB1 BPI fold containing family B member 1 [ Homo sapiens (human) ]

    Gene ID: 92747, updated on 9-Dec-2024

    Summary

    Official Symbol
    BPIFB1provided by HGNC
    Official Full Name
    BPI fold containing family B member 1provided by HGNC
    Primary source
    HGNC:HGNC:16108
    See related
    Ensembl:ENSG00000125999 AllianceGenome:HGNC:16108
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LPLUNC1; C20orf114
    Summary
    The protein encoded by this gene may be involved in the innate immune response to bacterial exposure in the mouth, nasal cavities, and lungs. The encoded protein is secreted and is a member of the BPI/LBP/PLUNC protein superfamily. This gene is found with other members of the superfamily in a cluster on chromosome 20. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in stomach (RPKM 277.8), lung (RPKM 49.9) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See BPIFB1 in Genome Data Viewer
    Location:
    20q11.21
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (33283214..33309871)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (35000716..35037069)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (31871020..31897677)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372593 Neighboring gene BPI fold containing family A member 1 Neighboring gene ribosomal protein L12 pseudogene 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31869092-31869592 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31869593-31870093 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31877426-31878386 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31878387-31879347 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17727 Neighboring gene uncharacterized LOC124904888 Neighboring gene uncharacterized LOC105372594 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31899476-31899976 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31899977-31900477 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31909477-31909976 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31911786-31912403 Neighboring gene BPI fold containing family B member 5, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17728 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31934530-31935364 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31937032-31937864 Neighboring gene BPI fold containing family B member 9, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    BPI fold-containing family B member 1
    Names
    VEMSGP
    long palate, lung and nasal epithelium carcinoma associated 1
    long palate, lung and nasal epithelium carcinoma-associated protein 1
    von Ebner minor salivary gland protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033197.3NP_149974.2  BPI fold-containing family B member 1 precursor

      See identical proteins and their annotated locations for NP_149974.2

      Status: REVIEWED

      Source sequence(s)
      AF364078, CD696225
      Consensus CDS
      CCDS13218.1
      UniProtKB/Swiss-Prot
      A8K2H8, Q5QP43, Q6UWY1, Q6ZRU7, Q8TDL5, Q96HK6, Q9BQP8, Q9BWZ6, Q9H4V6
      UniProtKB/TrEMBL
      B2R7Z6
      Related
      ENSP00000253354.1, ENST00000253354.2
      Conserved Domains (2) summary
      cd00025
      Location:26262
      BPI1; BPI/LBP/CETP N-terminal domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) N-terminal domain; binds to and neutralizes lipopolysaccharides from the outer ...
      cd00026
      Location:279474
      BPI2; BPI/LBP/CETP C-terminal domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) C-terminal domain; binds to and neutralizes lipopolysaccharides from the outer ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      33283214..33309871
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      35000716..35037069
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054324225.1XP_054180200.1  BPI fold-containing family B member 1 isoform X1

      UniProtKB/Swiss-Prot
      A8K2H8, Q5QP43, Q6UWY1, Q6ZRU7, Q8TDL5, Q96HK6, Q9BQP8, Q9BWZ6, Q9H4V6
      UniProtKB/TrEMBL
      B2R7Z6