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    CARD14 caspase recruitment domain family member 14 [ Homo sapiens (human) ]

    Gene ID: 79092, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CARD14provided by HGNC
    Official Full Name
    caspase recruitment domain family member 14provided by HGNC
    Primary source
    HGNC:HGNC:16446
    See related
    Ensembl:ENSG00000141527 MIM:607211; AllianceGenome:HGNC:16446
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRP; PSS1; BIMP2; CARMA2; PSORS2
    Summary
    This gene encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that are involved in a diverse array of cellular processes including cellular adhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
    Expression
    Broad expression in skin (RPKM 4.8), adrenal (RPKM 1.8) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CARD14 in Genome Data Viewer
    Location:
    17q25.3
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (80170030..80209331)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (81070412..81109756)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (78143829..78183130)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9099 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12928 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78083610-78084585 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:78086615-78087127 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78091523-78092024 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:78097302-78097924 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:78107357-78107522 Neighboring gene alpha glucosidase Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:78120154-78120868 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:78120869-78121581 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:78121582-78122295 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78122296-78123008 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:78126203-78126704 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:78126705-78127204 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:78129355-78129892 Neighboring gene eukaryotic translation initiation factor 4A3 Neighboring gene Sharpr-MPRA regulatory region 5287 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:78151904-78153103 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:78163065-78163581 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:78178385-78179584 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:78183891-78184046 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12929 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9102 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9103 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78195951-78196788 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78196789-78197626 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78200105-78200606 Neighboring gene N-sulfoglucosamine sulfohydrolase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78209849-78210638 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78210639-78211426 Neighboring gene solute carrier family 26 member 11 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:78227308-78228024 Neighboring gene SLC26A11-RNF213 intergenic CAGE-defined mid-level expression enhancer Neighboring gene CRISPRi-validated cis-regulatory element chr17.5742 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9104 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9105 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9106 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:78237270-78237826 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9107 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78247837-78248435 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78251821-78252439 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78258533-78259093 Neighboring gene ring finger protein 213 Neighboring gene RNF213 antisense RNA 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:78345568-78346767 Neighboring gene MPRA-validated peak3024 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78354122-78354622 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:78359110-78360309 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78369069-78369570 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78371216-78371723 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78371724-78372230

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Variant analysis of CARD14 in a Chinese Han population with psoriasis vulgaris and generalized pustular psoriasis. Qin P, et al. J Invest Dermatol, 2014 Dec. PMID 24999592, Free PMC Article
    2. Loss-of-function mutations in caspase recruitment domain-containing protein 14 (CARD14) are associated with a severe variant of atopic dermatitis. Peled A, et al. J Allergy Clin Immunol, 2019 Jan. PMID 30248356
    3. CARD14-associated papulosquamous eruption: A spectrum including features of psoriasis and pityriasis rubra pilaris. Craiglow BG, et al. J Am Acad Dermatol, 2018 Sep. PMID 29477734, Free PMC Article
    4. Beneficial effect of ustekinumab in familial pityriasis rubra pilaris with a new missense mutation in CARD14. Lwin SM, et al. Br J Dermatol, 2018 Apr. PMID 28301045
    5. Pityriasis Rubra Pilaris Type V as an Autoinflammatory Disease by CARD14 Mutations. Takeichi T, et al. JAMA Dermatol, 2017 Jan 1. PMID 27760266

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulation of MYC by CARD14 in human epithelium is a determinant of epidermal homeostasis and disease.
      Title: Regulation of MYC by CARD14 in human epithelium is a determinant of epidermal homeostasis and disease.
    2. Polo-like kinase 1 (PLK1) is a novel CARD14-binding protein in keratinocytes.
      Title: Polo-like kinase 1 (PLK1) is a novel CARD14-binding protein in keratinocytes.
    3. A novel mutation in a CARD14-associated papulosquamous eruption.
      Title: A novel mutation in a CARD14-associated papulosquamous eruption.
    4. Correlation of IL36RN and CARD14 mutations with clinical manifestations and laboratory findings in patients with generalised pustular psoriasis.
      Title: Correlation of IL36RN and CARD14 mutations with clinical manifestations and laboratory findings in patients with generalised pustular psoriasis.
    5. Damaging Alleles Affecting Multiple CARD14 Domains Are Associated with Palmoplantar Pustulosis.
      Title: Damaging Alleles Affecting Multiple CARD14 Domains Are Associated with Palmoplantar Pustulosis.
    6. Association between CARD14 gene polymorphisms and psoriasis vulgaris in Hainan Han population based on exon sequencing: A case-control study.
      Title: Association between CARD14 gene polymorphisms and psoriasis vulgaris in Hainan Han population based on exon sequencing: A case-control study.
    7. Association of CARD14 Single-Nucleotide Polymorphisms with Psoriasis.
      Title: Association of CARD14 Single-Nucleotide Polymorphisms with Psoriasis.
    8. Novel role for caspase recruitment domain family member 14 and its genetic variant rs11652075 in skin filaggrin homeostasis.
      Title: Novel role for caspase recruitment domain family member 14 and its genetic variant rs11652075 in skin filaggrin homeostasis.
    9. GJB2 mutations in Iranian Azeri population with autosomal recessive nonsyndromic hearing loss (ARNSHL): First report of c.238 C>A mutation in Iran.
      Title: GJB2 mutations in Iranian Azeri population with autosomal recessive nonsyndromic hearing loss (ARNSHL): First report of c.238 C>A mutation in Iran.
    10. CARD14-associated papulosquamous eruption (CAPE) in pediatric patients: Three additional cases and review of the literature.
      Title: CARD14-associated papulosquamous eruption (CAPE) in pediatric patients: Three additional cases and review of the literature.
    Submit: New GeneRIF Correction See all GeneRIFs (60)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Pityriasis rubra pilaris
    MedGen: C0032027 OMIM: 173200 GeneReviews: Not available
    		Compare labs
    Psoriasis 2
    MedGen: C1864497 OMIM: 602723 GeneReviews: Not available
    		Compare labs

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2013-08-01)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2013-08-01)

    ClinGen Genome Curation Page

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ38097

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables CARD domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation of NF-kappaB-inducing kinase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tumor necrosis factor-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in aggresome IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    caspase recruitment domain-containing protein 14
    Names
    CARD-containing MAGUK protein 2
    bcl10-interacting maguk protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032778.1 RefSeqGene

      Range
      5039..44340
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1330

    mRNA and Protein(s)

    1. NM_001257970.1 → NP_001244899.1  caspase recruitment domain-containing protein 14 isoform 3

      See identical proteins and their annotated locations for NP_001244899.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks several exons and its transcription extends past a splice site that is used in variant 1. The encoded isoform 3 has a shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AC087741, BC018142
      Consensus CDS
      CCDS58605.1
      UniProtKB/TrEMBL
      A0A494C199
      Related
      ENSP00000461806.1, ENST00000570421.5
      Conserved Domains (5) summary
      cd00992
      Location:583 → 655
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd08806
      Location:19 → 104
      CARD_CARD14_CARMA2; Caspase activation and recruitment domain of CARD14-like proteins
      pfam15252
      Location:410 → 481
      DUF4589; Domain of unknown function (DUF4589)
      cl17036
      Location:680 → 740
      SH3; Src Homology 3 domain superfamily
      cl25732
      Location:151 → 409
      SMC_N; RecF/RecN/SMC N terminal domain

    2. NM_001366385.1 → NP_001353314.1  caspase recruitment domain-containing protein 14 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC087741
      Consensus CDS
      CCDS11768.1
      UniProtKB/Swiss-Prot
      B8QQJ3, Q9BVB5, Q9BXL6
      UniProtKB/TrEMBL
      A0A494C1N2
      Related
      ENSP00000498071.1, ENST00000648509.2
      Conserved Domains (5) summary
      cd00992
      Location:583 → 655
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd08806
      Location:19 → 104
      CARD_CARD14_CARMA2; Caspase activation and recruitment domain of CARD14-like proteins
      cl17036
      Location:680 → 742
      SH3; Src Homology 3 domain superfamily
      cl17190
      Location:858 → 961
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
      cl25732
      Location:151 → 448
      SMC_N; RecF/RecN/SMC N terminal domain

    3. NM_024110.4 → NP_077015.2  caspase recruitment domain-containing protein 14 isoform 1

      See identical proteins and their annotated locations for NP_077015.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 5 encode the same isoform.
      Source sequence(s)
      AC087741, AF322642, BU617627
      Consensus CDS
      CCDS11768.1
      UniProtKB/Swiss-Prot
      B8QQJ3, Q9BVB5, Q9BXL6
      UniProtKB/TrEMBL
      A0A494C1N2
      Related
      ENSP00000344549.2, ENST00000344227.6
      Conserved Domains (5) summary
      cd00992
      Location:583 → 655
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd08806
      Location:19 → 104
      CARD_CARD14_CARMA2; Caspase activation and recruitment domain of CARD14-like proteins
      cl17036
      Location:680 → 742
      SH3; Src Homology 3 domain superfamily
      cl17190
      Location:858 → 961
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
      cl25732
      Location:151 → 448
      SMC_N; RecF/RecN/SMC N terminal domain

    4. NM_052819.3 → NP_438170.1  caspase recruitment domain-containing protein 14 isoform 2

      See identical proteins and their annotated locations for NP_438170.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks several exons at the 5' and 3' ends and its transcription extends past a splice site that is used in variant 1. The encoded isoform 2 has a shorter N-terminus and a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC087741, BC001326
      UniProtKB/TrEMBL
      B4DKY0
      Related
      ENST00000573754.5
      Conserved Domains (2) summary
      COG1196
      Location:8 → 211
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00992
      Location:346 → 381
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    RNA

    1. NR_047566.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC087741, AK091123, BU617627, DA461380
      Related
      ENST00000575500.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      80170030..80209331
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047436713.1 → XP_047292669.1  caspase recruitment domain-containing protein 14 isoform X1

      UniProtKB/Swiss-Prot
      B8QQJ3, Q9BVB5, Q9BXL6
      UniProtKB/TrEMBL
      A0A494C1N2
      Related
      ENSP00000499145.1, ENST00000651672.1

    2. XM_047436719.1 → XP_047292675.1  caspase recruitment domain-containing protein 14 isoform X3

      UniProtKB/TrEMBL
      A0A494C1N2

    3. XM_047436714.1 → XP_047292670.1  caspase recruitment domain-containing protein 14 isoform X1

      UniProtKB/Swiss-Prot
      B8QQJ3, Q9BVB5, Q9BXL6
      UniProtKB/TrEMBL
      A0A494C1N2

    4. XM_011525213.2 → XP_011523515.1  caspase recruitment domain-containing protein 14 isoform X1

      See identical proteins and their annotated locations for XP_011523515.1

      UniProtKB/Swiss-Prot
      B8QQJ3, Q9BVB5, Q9BXL6
      UniProtKB/TrEMBL
      A0A494C1N2
      Conserved Domains (5) summary
      cd00992
      Location:583 → 655
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd08806
      Location:19 → 104
      CARD_CARD14_CARMA2; Caspase activation and recruitment domain of CARD14-like proteins
      cl17036
      Location:680 → 742
      SH3; Src Homology 3 domain superfamily
      cl17190
      Location:858 → 961
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
      cl25732
      Location:151 → 448
      SMC_N; RecF/RecN/SMC N terminal domain

    5. XM_011525216.2 → XP_011523518.1  caspase recruitment domain-containing protein 14 isoform X1

      See identical proteins and their annotated locations for XP_011523518.1

      UniProtKB/Swiss-Prot
      B8QQJ3, Q9BVB5, Q9BXL6
      UniProtKB/TrEMBL
      A0A494C1N2
      Conserved Domains (5) summary
      cd00992
      Location:583 → 655
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd08806
      Location:19 → 104
      CARD_CARD14_CARMA2; Caspase activation and recruitment domain of CARD14-like proteins
      cl17036
      Location:680 → 742
      SH3; Src Homology 3 domain superfamily
      cl17190
      Location:858 → 961
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
      cl25732
      Location:151 → 448
      SMC_N; RecF/RecN/SMC N terminal domain

    6. XM_011525218.2 → XP_011523520.1  caspase recruitment domain-containing protein 14 isoform X1

      See identical proteins and their annotated locations for XP_011523520.1

      UniProtKB/Swiss-Prot
      B8QQJ3, Q9BVB5, Q9BXL6
      UniProtKB/TrEMBL
      A0A494C1N2
      Conserved Domains (5) summary
      cd00992
      Location:583 → 655
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd08806
      Location:19 → 104
      CARD_CARD14_CARMA2; Caspase activation and recruitment domain of CARD14-like proteins
      cl17036
      Location:680 → 742
      SH3; Src Homology 3 domain superfamily
      cl17190
      Location:858 → 961
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
      cl25732
      Location:151 → 448
      SMC_N; RecF/RecN/SMC N terminal domain

    7. XM_047436715.1 → XP_047292671.1  caspase recruitment domain-containing protein 14 isoform X1

      UniProtKB/Swiss-Prot
      B8QQJ3, Q9BVB5, Q9BXL6
      UniProtKB/TrEMBL
      A0A494C1N2
      Related
      ENSP00000458715.1, ENST00000573882.5

    8. XM_047436717.1 → XP_047292673.1  caspase recruitment domain-containing protein 14 isoform X1

      UniProtKB/Swiss-Prot
      B8QQJ3, Q9BVB5, Q9BXL6
      UniProtKB/TrEMBL
      A0A494C1N2

    9. XM_047436716.1 → XP_047292672.1  caspase recruitment domain-containing protein 14 isoform X1

      UniProtKB/Swiss-Prot
      B8QQJ3, Q9BVB5, Q9BXL6
      UniProtKB/TrEMBL
      A0A494C1N2

    10. XM_047436718.1 → XP_047292674.1  caspase recruitment domain-containing protein 14 isoform X2

      UniProtKB/TrEMBL
      A0A494C1N2

    11. XM_047436720.1 → XP_047292676.1  caspase recruitment domain-containing protein 14 isoform X4

      UniProtKB/TrEMBL
      A0A494C0J4
      Related
      ENSP00000498570.1, ENST00000650867.1

    12. XM_047436721.1 → XP_047292677.1  caspase recruitment domain-containing protein 14 isoform X5

      UniProtKB/TrEMBL
      A0A494C199

    13. XM_047436722.1 → XP_047292678.1  caspase recruitment domain-containing protein 14 isoform X6

      UniProtKB/TrEMBL
      A0A494C199, A0A994J6G4
      Related
      ENSP00000515382.1, ENST00000703566.1

    14. XM_047436723.1 → XP_047292679.1  caspase recruitment domain-containing protein 14 isoform X7

      UniProtKB/TrEMBL
      A0A494BZY0
      Related
      ENSP00000498274.1, ENST00000651068.1

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791802.1 Reference GRCh38.p14 PATCHES

      Range
      194698..234037
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333205.1 → XP_054189180.1  caspase recruitment domain-containing protein 14 isoform X1

      UniProtKB/Swiss-Prot
      B8QQJ3, Q9BVB5, Q9BXL6
      UniProtKB/TrEMBL
      A0A494C1N2

    2. XM_054333202.1 → XP_054189177.1  caspase recruitment domain-containing protein 14 isoform X1

      UniProtKB/Swiss-Prot
      B8QQJ3, Q9BVB5, Q9BXL6
      UniProtKB/TrEMBL
      A0A494C1N2

    3. XM_054333204.1 → XP_054189179.1  caspase recruitment domain-containing protein 14 isoform X1

      UniProtKB/Swiss-Prot
      B8QQJ3, Q9BVB5, Q9BXL6
      UniProtKB/TrEMBL
      A0A494C1N2

    4. XM_054333200.1 → XP_054189175.1  caspase recruitment domain-containing protein 14 isoform X1

      UniProtKB/Swiss-Prot
      B8QQJ3, Q9BVB5, Q9BXL6
      UniProtKB/TrEMBL
      A0A494C1N2

    5. XM_054333209.1 → XP_054189184.1  caspase recruitment domain-containing protein 14 isoform X1

      UniProtKB/Swiss-Prot
      B8QQJ3, Q9BVB5, Q9BXL6
      UniProtKB/TrEMBL
      A0A494C1N2

    6. XM_054333208.1 → XP_054189183.1  caspase recruitment domain-containing protein 14 isoform X1

      UniProtKB/Swiss-Prot
      B8QQJ3, Q9BVB5, Q9BXL6
      UniProtKB/TrEMBL
      A0A494C1N2

    7. XM_054333201.1 → XP_054189176.1  caspase recruitment domain-containing protein 14 isoform X1

      UniProtKB/Swiss-Prot
      B8QQJ3, Q9BVB5, Q9BXL6
      UniProtKB/TrEMBL
      A0A494C1N2

    8. XM_054333206.1 → XP_054189181.1  caspase recruitment domain-containing protein 14 isoform X1

      UniProtKB/Swiss-Prot
      B8QQJ3, Q9BVB5, Q9BXL6
      UniProtKB/TrEMBL
      A0A494C1N2

    9. XM_054333203.1 → XP_054189178.1  caspase recruitment domain-containing protein 14 isoform X1

      UniProtKB/Swiss-Prot
      B8QQJ3, Q9BVB5, Q9BXL6
      UniProtKB/TrEMBL
      A0A494C1N2

    10. XM_054333207.1 → XP_054189182.1  caspase recruitment domain-containing protein 14 isoform X2

      UniProtKB/TrEMBL
      A0A494C1N2

    11. XM_054333210.1 → XP_054189185.1  caspase recruitment domain-containing protein 14 isoform X4

      UniProtKB/TrEMBL
      A0A494C0J4

    12. XM_054333211.1 → XP_054189186.1  caspase recruitment domain-containing protein 14 isoform X5

      UniProtKB/TrEMBL
      A0A494C199

    13. XM_054333212.1 → XP_054189187.1  caspase recruitment domain-containing protein 14 isoform X6

      UniProtKB/TrEMBL
      A0A494C199, A0A994J6G4

    14. XM_054333213.1 → XP_054189188.1  caspase recruitment domain-containing protein 14 isoform X7

      UniProtKB/TrEMBL
      A0A494BZY0

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      81070412..81109756
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054317155.1 → XP_054173130.1  caspase recruitment domain-containing protein 14 isoform X1

      UniProtKB/TrEMBL
      A0A494C1N2

    2. XM_054317152.1 → XP_054173127.1  caspase recruitment domain-containing protein 14 isoform X1

      UniProtKB/TrEMBL
      A0A494C1N2

    3. XM_054317154.1 → XP_054173129.1  caspase recruitment domain-containing protein 14 isoform X1

      UniProtKB/TrEMBL
      A0A494C1N2

    4. XM_054317150.1 → XP_054173125.1  caspase recruitment domain-containing protein 14 isoform X1

      UniProtKB/TrEMBL
      A0A494C1N2

    5. XM_054317159.1 → XP_054173134.1  caspase recruitment domain-containing protein 14 isoform X1

      UniProtKB/TrEMBL
      A0A494C1N2

    6. XM_054317158.1 → XP_054173133.1  caspase recruitment domain-containing protein 14 isoform X1

      UniProtKB/TrEMBL
      A0A494C1N2

    7. XM_054317151.1 → XP_054173126.1  caspase recruitment domain-containing protein 14 isoform X1

      UniProtKB/TrEMBL
      A0A494C1N2

    8. XM_054317156.1 → XP_054173131.1  caspase recruitment domain-containing protein 14 isoform X1

      UniProtKB/TrEMBL
      A0A494C1N2

    9. XM_054317153.1 → XP_054173128.1  caspase recruitment domain-containing protein 14 isoform X1

      UniProtKB/TrEMBL
      A0A494C1N2

    10. XM_054317157.1 → XP_054173132.1  caspase recruitment domain-containing protein 14 isoform X2

      UniProtKB/TrEMBL
      A0A494C1N2

    11. XM_054317160.1 → XP_054173135.1  caspase recruitment domain-containing protein 14 isoform X4

    12. XM_054317161.1 → XP_054173136.1  caspase recruitment domain-containing protein 14 isoform X5

      UniProtKB/TrEMBL
      A0A494C199

    13. XM_054317162.1 → XP_054173137.1  caspase recruitment domain-containing protein 14 isoform X6

      UniProtKB/TrEMBL
      A0A494C199

    14. XM_054317163.1 → XP_054173138.1  caspase recruitment domain-containing protein 14 isoform X7

      UniProtKB/TrEMBL
      A0A494BZY0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BXL6.2 GenPept UniProtKB/Swiss-Prot:Q9BXL6

    Gene LinkOut

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