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    septin5a septin 5a [ Danio rerio (zebrafish) ]

    Gene ID: 335925, updated on 9-Dec-2024

    Summary

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    Official Symbol
    septin5aprovided by ZNC
    Official Full Name
    septin 5aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-7868
    See related
    Ensembl:ENSDARG00000013843 AllianceGenome:ZFIN:ZDB-GENE-030131-7868
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sept5; sept5a; fj37h04; zgc:73218; wu:fj37h04
    Summary
    Predicted to enable GTPase activity and molecular adaptor activity. Predicted to be involved in cytoskeleton-dependent cytokinesis; protein localization; and regulation of exocytosis. Predicted to be located in plasma membrane. Predicted to be part of septin complex. Predicted to be active in cell division site; cytoskeleton; and synaptic vesicle. Is expressed in brain; retina; and spinal cord. Orthologous to human SEPTIN5 (septin 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See septin5a in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (4588886..4618586, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (4532180..4562319, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 37 Neighboring gene glycoprotein Ib platelet subunit beta Neighboring gene zgc:63587 Neighboring gene claudin 5a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Expression of sept3, sept5a and sept5b in the Developing and Adult Nervous System of the Zebrafish (Danio rerio). Helmprobst F, et al. Front Neuroanat, 2017. PMID 28261064, Free PMC Article
    2. A transgenic zebrafish model for the in vivo study of the blood and choroid plexus brain barriers using claudin 5. van Leeuwen LM, et al. Biol Open, 2018 Feb 2. PMID 29437557, Free PMC Article
    3. Phylogenetic and evolutionary analysis of the septin protein family in metazoan. Cao L, et al. FEBS Lett, 2007 Nov 27. PMID 17967425
    4. Zebrafish null mutants of Sept6 and Sept15 are viable but more susceptible to Shigella infection. Torraca V, et al. Cytoskeleton (Hoboken), 2023 Jul-Aug. PMID 36855298, Free PMC Article
    5. Analysis of protein expression in zebrafish during gonad differentiation by targeted proteomics. Groh KJ, et al. Gen Comp Endocrinol, 2013 Nov 1. PMID 23968773

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of septin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in septin ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    septin 5a
    Names
    septin 5
    NP_956282.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199988.1 → NP_956282.1  septin 5a

      See identical proteins and their annotated locations for NP_956282.1

      Status: PROVISIONAL

      Source sequence(s)
      BC059564
      UniProtKB/TrEMBL
      Q6PBW0
      Related
      ENSDARP00000023816.8, ENSDART00000025535.8
      Conserved Domains (2) summary
      COG5019
      Location:21 → 367
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00735
      Location:39 → 312
      Septin; Septin

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      4588886..4618586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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