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    myo1ea myosin IEa [ Danio rerio (zebrafish) ]

    Gene ID: 555285, updated on 2-Nov-2024

    Summary

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    Official Symbol
    myo1eaprovided by ZNC
    Official Full Name
    myosin IEaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5127
    See related
    Ensembl:ENSDARG00000036179 AllianceGenome:ZFIN:ZDB-GENE-030131-5127
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    myo1e; wu:fc15g04; wu:fe49h01
    Summary
    Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within glomerular filtration and glomerulus development. Predicted to be part of myosin complex. Predicted to be active in several cellular components, including actin cytoskeleton; microvillus; and plasma membrane. Is expressed in somite 2 and somite 3. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 6. Orthologous to human MYO1E (myosin IE). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See myo1ea in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (30632229..30722956, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (30361016..30451870, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 111 Neighboring gene cyclin B2 Neighboring gene myotubularin related protein 10 Neighboring gene M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Myo1e impairment results in actin reorganization, podocyte dysfunction, and proteinuria in zebrafish and cultured podocytes. Mao J, et al. PLoS One, 2013. PMID 23977349, Free PMC Article
    2. Myosin-1 inhibition by PClP affects membrane shape, cortical actin distribution and lipid droplet dynamics in early Zebrafish embryos. Gupta P, et al. PLoS One, 2017. PMID 28678859, Free PMC Article
    3. Expression of unconventional myosin genes during neuronal development in zebrafish. Sittaramane V, et al. Gene Expr Patterns, 2008 Feb. PMID 18078791, Free PMC Article
    4. Consequences of lineage-specific gene loss on functional evolution of surviving paralogs: ALDH1A and retinoic acid signaling in vertebrate genomes. Cañestro C, et al. PLoS Genet, 2009 May. PMID 19478994, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Myo1e is a key component contributing to the functional integrity of podocytes.
      Title: Myo1e impairment results in actin reorganization, podocyte dysfunction, and proteinuria in zebrafish and cultured podocytes.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within glomerular filtration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in glomerulus development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within glomerulus development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microvillus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    myosin-Ie; unconventional myosin-Ie
    Names
    myo1e1
    myosin IE, a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      30632229..30722956 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005168926.5 → XP_005168983.1  unconventional myosin-Ie isoform X1

      UniProtKB/TrEMBL
      A0A8M2BG72, E7FDV0
      Related
      ENSDARP00000052538.4, ENSDART00000052539.7
      Conserved Domains (4) summary
      cd11827
      Location:1064 → 1116
      SH3_MyoIe_If_like; Src homology 3 domain of Myosins Ie, If, and similar proteins
      smart00242
      Location:14 → 692
      MYSc; Myosin. Large ATPases
      cd01378
      Location:33 → 679
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:719 → 904
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

    2. XM_677757.10 → XP_682849.4  unconventional myosin-Ie isoform X3

      UniProtKB/TrEMBL
      A0A8N7TD18
      Related
      ENSDARP00000157042.1, ENSDART00000188360.1
      Conserved Domains (4) summary
      cd11827
      Location:1053 → 1105
      SH3_MyoIe_If_like; Src homology 3 domain of Myosins Ie, If, and similar proteins
      smart00242
      Location:14 → 692
      MYSc; Myosin. Large ATPases
      cd01378
      Location:33 → 679
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:719 → 904
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

    3. XM_005168927.5 → XP_005168984.1  unconventional myosin-Ie isoform X2

      UniProtKB/TrEMBL
      A0A8M2BG81
      Conserved Domains (4) summary
      cd11827
      Location:1063 → 1115
      SH3_MyoIe_If_like; Src homology 3 domain of Myosins Ie, If, and similar proteins
      smart00242
      Location:14 → 692
      MYSc; Myosin. Large ATPases
      cd01378
      Location:33 → 679
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:719 → 904
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
    Nucleotide Protein Strain
    Heading Accession and Version

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