DMRT1 doublesex and mab-3 related transcription factor 1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: DMRT1provided by CGNC
Full Name: doublesex and mab-3 related transcription factor 1provided by CGNC
Primary source: CGNC:7724
See related: Ensembl:ENSGALG00010011437
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: Z

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	Z	NC_052572.1 (26451248..26506925)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	Z	NC_059536.1 (26451234..26506925)

Chromosome Z - NC_052572.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Primary sex determination in birds depends on DMRT1 dosage, but gonadal sex does not determine adult secondary sex characteristics.
Title: Primary sex determination in birds depends on DMRT1 dosage, but gonadal sex does not determine adult secondary sex characteristics.
Study shows that DMRT1 is expressed in the paired Mullerian ducts in the chicken embryo, where it is required for duct formation.
Title: DMRT1 is required for Müllerian duct formation in the chicken embryo.
DMRT1 is an essential sex-linked regulator of gonadal differentiation in avians.
Title: Over-expression of DMRT1 induces the male pathway in embryonic chicken gonads.
Gonadal somatic cells in the male indifferent gonads showed stronger expressions of DMRT1 compared with those in the female indifferent gonads well before the presumptive period of sex determination.
Title: Spatiotemporal expression patterns of doublesex and mab-3 related transcription factor 1 in the chicken developing gonads and Mullerian ducts.
The expression of Dmrt1 in male (ZZ) gonads was not twice as much as in female (ZW) gonads, suggesting the existence of other regulatory mechanisms in addition to Z chromosome dosage effect.
Title: Temporospatial expression of Dmrt1 in chicken urogenital system (Gallus gallus) using whole mount in situ hybridization.
Down-regulation of DMRT1 and up-regulation of ER alpha in rooster testes treated with exogenous pEGFP-N1-chicken male hypemethylated (cMHM) plasmid might indicate a novel cMHM non-coding RNA-mediated mechanism in avian sex differentiation.
Title: Exogenous cMHM regulates the expression of DMRT1 and ER alpha in avian testes.
results indicate that DMRT1 is required for testis determination in the chicken; data support the Z dosage hypothesis for avian sex determination
Title: The avian Z-linked gene DMRT1 is required for male sex determination in the chicken.
Alternatively spliced DMRT1 b was expressed in embryo gonads and was higher in male than female gonads at stage 31.
Title: Multiple alternative splicing in gonads of chicken DMRT1.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in sex differentiation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: doublesex- and mab-3-related transcription factor 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001101831.3 → NP_001095301.2 doublesex- and mab-3-related transcription factor 1

Status: VALIDATED

Source sequence(s)

JAENSK010000089

UniProtKB/TrEMBL

A0A8V0YD84, A0A8V0YHW9

Related

ENSGALP00010015619.1, ENSGALT00010027365.1

Conserved Domains (2) summary

pfam00751
Location:43 → 89

DM; DM DNA binding domain

pfam12374
Location:101 → 174

Dmrt1; Double-sex mab3 related transcription factor 1

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052572.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

26451248..26506925

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_040655644.2 → XP_040511578.1 doublesex- and mab-3-related transcription factor 1 isoform X1

UniProtKB/TrEMBL

A0A8V0YD84

Related

ENSGALP00010015621.1, ENSGALT00010027367.1

Conserved Domains (1) summary

smart00301
Location:43 → 96

DM; Doublesex DNA-binding motif