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    Mfsd3 major facilitator superfamily domain containing 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500899, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mfsd3provided by RGD
    Official Full Name
    major facilitator superfamily domain containing 3provided by RGD
    Primary source
    RGD:1560274
    See related
    EnsemblRapid:ENSRNOG00000015685 AllianceGenome:RGD:1560274
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Orthologous to human MFSD3 (major facilitator superfamily domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 64.6), Liver (RPKM 60.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mfsd3 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (110300254..110304108)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (108419644..108423469)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (117763395..117765904)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 16A Neighboring gene glutamic--pyruvic transaminase Neighboring gene RecQ like helicase 4 Neighboring gene leucine rich repeat containing 14 Neighboring gene leucine rich repeat containing 24 Neighboring gene similar to human chromosome 8 open reading frame 82

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114471

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    major facilitator superfamily domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024908.1 → NP_001020079.1  major facilitator superfamily domain-containing protein 3

      See identical proteins and their annotated locations for NP_001020079.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097424
      UniProtKB/Swiss-Prot
      Q4V8E5
      Related
      ENSRNOP00000021208.3, ENSRNOT00000021208.7
      Conserved Domains (1) summary
      cd17485
      Location:8 → 406
      MFS_MFSD3; Major facilitator superfamily domain containing 3 protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      110300254..110304108
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006241859.5 → XP_006241921.1  major facilitator superfamily domain-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006241921.1

      UniProtKB/TrEMBL
      A6HSC8
      Conserved Domains (1) summary
      cl21472
      Location:8 → 402
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V8E5.1 GenPept UniProtKB/Swiss-Prot:Q4V8E5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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