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    HSBP1L1 heat shock factor binding protein 1 like 1 [ Homo sapiens (human) ]

    Gene ID: 440498, updated on 28-Oct-2024

    Summary

    Official Symbol
    HSBP1L1provided by HGNC
    Official Full Name
    heat shock factor binding protein 1 like 1provided by HGNC
    Primary source
    HGNC:HGNC:37243
    See related
    Ensembl:ENSG00000226742 AllianceGenome:HGNC:37243
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable transcription corepressor activity. Predicted to be involved in cellular heat acclimation. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in colon (RPKM 10.7), kidney (RPKM 8.1) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See HSBP1L1 in Genome Data Viewer
    Location:
    18q23
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (79964643..79970822)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (80241167..80247343)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (77724643..77730822)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:77664167-77664802 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:77672372-77673288 Neighboring gene solute carrier family 66 member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9579 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9580 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9581 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9582 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9583 Neighboring gene uncharacterized LOC124904336 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr18:77717730-77718328 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr18:77718329-77718926 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:77720052-77720736 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13547 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9584 Neighboring gene thioredoxin like 4A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9585 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9586 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:77762974-77763187 Neighboring gene OCT4 hESC enhancer GRCh37_chr18:77766658-77767159 Neighboring gene Sharpr-MPRA regulatory region 15651 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9587 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:77793921-77794077 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9589 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9590 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:77808538-77809737 Neighboring gene ribosome binding factor A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:77825575-77826076 Neighboring gene RBFA downstream neighbor Neighboring gene solute carrier family 25 member 6 pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10967, MGC189743

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cellular heat acclimation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    heat shock factor-binding protein 1-like protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136180.2NP_001129652.1  heat shock factor-binding protein 1-like protein 1

      See identical proteins and their annotated locations for NP_001129652.1

      Status: VALIDATED

      Source sequence(s)
      AC114341, BC040056, BC157848, CA444419, DA919112
      Consensus CDS
      CCDS45886.1
      UniProtKB/Swiss-Prot
      B2RXG9, C9JCN9
      Related
      ENSP00000414236.1, ENST00000451882.3
      Conserved Domains (1) summary
      pfam06825
      Location:1462
      HSBP1; Heat shock factor binding protein 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      79964643..79970822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      80241167..80247343
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)