fem1c.L fem-1 homolog c L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: fem1c.L
Official Full Name: fem-1 homolog c L homeolog
Primary source: Xenbase:XB-GENE-998532
Locus tag: XELAEV_18007991mg
See related: EnsemblRapid:ENSXLAG00005025646 AllianceGenome:Xenbase:XB-GENE-998532
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: fem1c
Summary: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to act upstream of or within ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Predicted to be part of Cul2-RING ubiquitin ligase complex. Orthologous to human FEM1C (fem-1 homolog C). [provided by Alliance of Genome Resources, Nov 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 1L

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	1L	NC_054371.1 (186809321..186828192)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	1L	NC_030724.1 (173656892..173675748)

Chromosome 1L - NC_054371.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ubiquitin-like ligase-substrate adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Cul2-RING ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Go to the top of the page Help

Preferred Names: protein fem-1 homolog C

Names: FEM1-gamma

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001096694.1 → NP_001090163.1 protein fem-1 homolog C

See identical proteins and their annotated locations for NP_001090163.1

Status: PROVISIONAL

Source sequence(s)

BC111474

UniProtKB/Swiss-Prot

Q2T9K6

UniProtKB/TrEMBL

A0A974I588

Related

ENSXLAP00005076237.1, ENSXLAT00005077821.1

Conserved Domains (5) summary

cd00204
Location:73 → 202

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:87 → 178

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:182 → 233

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:514 → 567

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:118 → 146

ANK; ANK repeat [structural motif]