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    PPFIBP2 PPFIA binding protein 2 [ Homo sapiens (human) ]

    Gene ID: 8495, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PPFIBP2provided by HGNC
    Official Full Name
    PPFIA binding protein 2provided by HGNC
    Primary source
    HGNC:HGNC:9250
    See related
    Ensembl:ENSG00000166387 MIM:603142; AllianceGenome:HGNC:9250
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Cclp1
    Summary
    This gene encodes a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. The encoded protein is a beta liprin and plays a role in axon guidance and neuronal synapse development by recruiting LAR protein-tyrosine phosphatases to the plasma membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
    Expression
    Ubiquitous expression in thyroid (RPKM 8.3), testis (RPKM 6.8) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PPFIBP2 in Genome Data Viewer
    Location:
    11p15.4
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (7513999..7667304)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (7572359..7725720)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (7535230..7679372)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene synaptotagmin 9 Neighboring gene Sharpr-MPRA regulatory region 13298 Neighboring gene NANOG hESC enhancer GRCh37_chr11:7472795-7473306 Neighboring gene SYT9 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4362 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4363 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:7506414-7506918 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4364 Neighboring gene leucine-rich repeat extensin-like protein 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4365 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3110 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4366 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4367 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4368 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4369 Neighboring gene MPRA-validated peak1190 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4371 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4370 Neighboring gene olfactomedin like 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4372 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4373 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:7584372-7584873 Neighboring gene uncharacterized LOC105376535 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:7595102-7595926 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:7595927-7596750 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:7599169-7599403 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4374 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:7651972-7653171 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4375 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:7672104-7673303 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4376 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4377 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3111 Neighboring gene uncharacterized LOC105376533 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:7712245-7713444 Neighboring gene cytochrome b5 reductase 2 Neighboring gene uncharacterized LOC124902626 Neighboring gene ovochymase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Molecular markers of endometrial carcinoma detected in uterine aspirates. Colas E, et al. Int J Cancer, 2011 Nov 15. PMID 21207424
    2. Germline mutations in PPFIBP2 are associated with lethal prostate cancer. Wu Y, et al. Prostate, 2018 Dec. PMID 30043417
    3. Crystal structure of the central coiled-coil domain from human liprin-β2. Stafford RL, et al. Biochemistry, 2011 May 10. PMID 21462929, Free PMC Article
    4. Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer. Wang M, et al. Nat Commun, 2015 Oct 7. PMID 26443449, Free PMC Article
    5. ERK2 drives tumour cell migration in three-dimensional microenvironments by suppressing expression of Rab17 and liprin-β2. von Thun A, et al. J Cell Sci, 2012 Mar 15. PMID 22328529

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. germline mutations in a novel gene, PPFIBP2, differentiated risk for lethal prostate cancer from low-risk cases and were associated with shorter survival times after diagnosis.
      Title: Germline mutations in PPFIBP2 are associated with lethal prostate cancer.
    2. Analysis of the role of liprin-beta1 and liprin-beta2 has shown that while liprin-beta1 contributes positively to tumour cell motility in vitro; liprin-beta2 has a negative effect on both cell motility and invasion.
      Title: Effects of the scaffold proteins liprin-α1, β1 and β2 on invasion by breast cancer cells.
    3. rs12791447 is associated with prostate cancer susceptibility in Asians. mRNA levels of PPFIBP2 are differentially expressed in prostate tumours and paired normal tissues.
      Title: Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer.
    4. Knockdown of either Rab17 or liprin-beta2 restores invasiveness of ERK2-depleted cells, indicating that ERK2 drives invasion of MDA-MB-231 cells by suppressing expression of these genes.
      Title: ERK2 drives tumour cell migration in three-dimensional microenvironments by suppressing expression of Rab17 and liprin-β2.
    5. analysis of crystal structure of the central coiled-coil domain from human liprin-beta2
      Title: Crystal structure of the central coiled-coil domain from human liprin-β2.
    6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    7. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. radiologic technologists.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC42541, DKFZp781K06126

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in neuromuscular junction development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular space HDA PubMed 
    is_active_in presynaptic active zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    liprin-beta-2
    Names
    PTPRF interacting protein, binding protein 2 (liprin beta 2)
    liprin beta 2
    protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256568.2 → NP_001243497.2  liprin-beta-2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC104237
      Consensus CDS
      CCDS58116.1
      UniProtKB/TrEMBL
      E9PP16
      Related
      ENSP00000435469.1, ENST00000528883.5
      Conserved Domains (4) summary
      cd09563
      Location:443 → 506
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:517 → 579
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:602 → 673
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      TIGR02168
      Location:1 → 205
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. NM_001256569.2 → NP_001243498.2  liprin-beta-2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC104237
      Consensus CDS
      CCDS58117.1
      UniProtKB/TrEMBL
      E9PP16
      Related
      ENSP00000437321.1, ENST00000530181.5
      Conserved Domains (4) summary
      cd09563
      Location:412 → 475
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:486 → 548
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:571 → 642
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      COG1196
      Location:26 → 212
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. NM_001351853.2 → NP_001338782.2  liprin-beta-2 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (4).
      Source sequence(s)
      AC104237, AC107884
      Conserved Domains (4) summary
      cd09563
      Location:566 → 629
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:640 → 702
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:725 → 796
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      TIGR02168
      Location:59 → 317
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    4. NM_001351854.2 → NP_001338783.2  liprin-beta-2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC104237, AC107884
      Conserved Domains (4) summary
      cd09563
      Location:555 → 618
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:629 → 691
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:714 → 785
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      TIGR02168
      Location:59 → 317
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    5. NM_001351855.2 → NP_001338784.2  liprin-beta-2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC104237, AC107884
      UniProtKB/TrEMBL
      E9PP16
      Conserved Domains (4) summary
      cd09563
      Location:566 → 629
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:640 → 702
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:725 → 796
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      TIGR02168
      Location:59 → 317
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    6. NM_001351856.2 → NP_001338785.2  liprin-beta-2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC104237, AC107884
      UniProtKB/TrEMBL
      E9PP16
      Conserved Domains (4) summary
      cd09563
      Location:557 → 620
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:631 → 693
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:716 → 787
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      TIGR02168
      Location:59 → 319
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    7. NM_001351857.2 → NP_001338786.2  liprin-beta-2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC104237, AC107884
      UniProtKB/TrEMBL
      E9PP16
      Conserved Domains (4) summary
      cd09563
      Location:489 → 552
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:563 → 625
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:648 → 719
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      TIGR02168
      Location:14 → 240
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    8. NM_001351858.2 → NP_001338787.2  liprin-beta-2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC104237, AC107884
      UniProtKB/TrEMBL
      E9PP16
      Conserved Domains (4) summary
      cd09563
      Location:478 → 541
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:552 → 614
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:637 → 708
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      TIGR02168
      Location:14 → 240
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    9. NM_001351859.2 → NP_001338788.2  liprin-beta-2 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC104237, AC107884
      Consensus CDS
      CCDS91429.1
      UniProtKB/TrEMBL
      A0A804HJY3, E9PP16
      Related
      ENSP00000507694.1, ENST00000684215.1
      Conserved Domains (4) summary
      cd09563
      Location:489 → 552
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:563 → 625
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:648 → 719
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      TIGR02168
      Location:14 → 240
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    10. NM_001351860.2 → NP_001338789.2  liprin-beta-2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC104237, AC107884
      UniProtKB/TrEMBL
      E9PP16
      Conserved Domains (4) summary
      cd09563
      Location:486 → 549
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:560 → 622
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:645 → 716
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      TIGR02168
      Location:36 → 248
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    11. NM_001351861.2 → NP_001338790.2  liprin-beta-2 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC104237, AC107884
      UniProtKB/TrEMBL
      E9PP16
      Conserved Domains (4) summary
      cd09563
      Location:478 → 541
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:552 → 614
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:637 → 708
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      TIGR02168
      Location:14 → 240
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    12. NM_001351862.2 → NP_001338791.2  liprin-beta-2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variant 1, encodes isoform 1.
      Source sequence(s)
      AC104237, AC107884
      Consensus CDS
      CCDS31419.1
      UniProtKB/Swiss-Prot
      B7Z433, E9PK77, O75337, Q8ND30, Q8WW26
      UniProtKB/TrEMBL
      E9PP16
      Conserved Domains (4) summary
      cd09563
      Location:555 → 618
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:629 → 691
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:714 → 785
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      TIGR02168
      Location:59 → 317
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    13. NM_003621.5 → NP_003612.3  liprin-beta-2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), as well as variant 13, encodes isoform 1.
      Source sequence(s)
      AC104237, AC107884
      Consensus CDS
      CCDS31419.1
      UniProtKB/Swiss-Prot
      B7Z433, E9PK77, O75337, Q8ND30, Q8WW26
      UniProtKB/TrEMBL
      E9PP16
      Related
      ENSP00000299492.4, ENST00000299492.9
      Conserved Domains (4) summary
      cd09563
      Location:555 → 618
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:629 → 691
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:714 → 785
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      TIGR02168
      Location:59 → 317
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RNA

    1. NR_147792.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC104237, AC107884

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      7513999..7667304
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011520415.4 → XP_011518717.1  liprin-beta-2 isoform X3

      Conserved Domains (7) summary
      cd09563
      Location:566 → 629
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:640 → 702
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:725 → 796
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      smart00454
      Location:566 → 630
      SAM; Sterile alpha motif
      pfam01519
      Location:110 → 161
      DUF16; Protein of unknown function DUF16
      pfam15290
      Location:212 → 366
      Syntaphilin; Golgi-localized syntaxin-1-binding clamp
      pfam15774
      Location:321 → 470
      DUF4702; Domain of unknown function (DUF4702)

    2. XM_047427751.1 → XP_047283707.1  liprin-beta-2 isoform X5

      UniProtKB/TrEMBL
      E9PP16

    3. XM_011520413.3 → XP_011518715.1  liprin-beta-2 isoform X1

      See identical proteins and their annotated locations for XP_011518715.1

      UniProtKB/TrEMBL
      A0A804HKA2
      Conserved Domains (7) summary
      cd09563
      Location:566 → 629
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:640 → 702
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:725 → 796
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      smart00454
      Location:566 → 630
      SAM; Sterile alpha motif
      pfam01519
      Location:110 → 161
      DUF16; Protein of unknown function DUF16
      pfam15290
      Location:212 → 366
      Syntaphilin; Golgi-localized syntaxin-1-binding clamp
      pfam15774
      Location:321 → 470
      DUF4702; Domain of unknown function (DUF4702)

    4. XM_047427750.1 → XP_047283706.1  liprin-beta-2 isoform X2

    5. XM_006718349.4 → XP_006718412.1  liprin-beta-2 isoform X1

      See identical proteins and their annotated locations for XP_006718412.1

      UniProtKB/TrEMBL
      A0A804HKA2
      Related
      ENSP00000507842.1, ENST00000684123.1
      Conserved Domains (7) summary
      cd09563
      Location:566 → 629
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:640 → 702
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:725 → 796
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      smart00454
      Location:566 → 630
      SAM; Sterile alpha motif
      pfam01519
      Location:110 → 161
      DUF16; Protein of unknown function DUF16
      pfam15290
      Location:212 → 366
      Syntaphilin; Golgi-localized syntaxin-1-binding clamp
      pfam15774
      Location:321 → 470
      DUF4702; Domain of unknown function (DUF4702)

    6. XM_011520416.4 → XP_011518718.1  liprin-beta-2 isoform X4

      Conserved Domains (7) summary
      cd09563
      Location:566 → 629
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:640 → 702
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:725 → 796
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      smart00454
      Location:566 → 630
      SAM; Sterile alpha motif
      pfam01519
      Location:110 → 161
      DUF16; Protein of unknown function DUF16
      pfam15290
      Location:212 → 366
      Syntaphilin; Golgi-localized syntaxin-1-binding clamp
      pfam15774
      Location:321 → 470
      DUF4702; Domain of unknown function (DUF4702)

    7. XM_005253177.4 → XP_005253234.1  liprin-beta-2 isoform X2

      Conserved Domains (6) summary
      cd09563
      Location:555 → 618
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:629 → 691
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:714 → 785
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      smart00454
      Location:555 → 619
      SAM; Sterile alpha motif
      pfam01519
      Location:110 → 161
      DUF16; Protein of unknown function DUF16
      pfam15290
      Location:212 → 366
      Syntaphilin; Golgi-localized syntaxin-1-binding clamp

    8. XM_011520414.3 → XP_011518716.1  liprin-beta-2 isoform X1

      See identical proteins and their annotated locations for XP_011518716.1

      UniProtKB/TrEMBL
      A0A804HKA2
      Conserved Domains (7) summary
      cd09563
      Location:566 → 629
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:640 → 702
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:725 → 796
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      smart00454
      Location:566 → 630
      SAM; Sterile alpha motif
      pfam01519
      Location:110 → 161
      DUF16; Protein of unknown function DUF16
      pfam15290
      Location:212 → 366
      Syntaphilin; Golgi-localized syntaxin-1-binding clamp
      pfam15774
      Location:321 → 470
      DUF4702; Domain of unknown function (DUF4702)

    9. XM_047427756.1 → XP_047283712.1  liprin-beta-2 isoform X14

      UniProtKB/TrEMBL
      E9PP16

    10. XM_006718352.3 → XP_006718415.1  liprin-beta-2 isoform X8

      UniProtKB/TrEMBL
      E9PP16
      Conserved Domains (6) summary
      cd09563
      Location:478 → 541
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:552 → 614
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:637 → 708
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      smart00454
      Location:478 → 542
      SAM; Sterile alpha motif
      pfam01519
      Location:33 → 84
      DUF16; Protein of unknown function DUF16
      pfam15290
      Location:135 → 289
      Syntaphilin; Golgi-localized syntaxin-1-binding clamp

    11. XM_024448725.2 → XP_024304493.2  liprin-beta-2 isoform X14

      UniProtKB/TrEMBL
      E9PP16

    12. XM_011520417.3 → XP_011518719.1  liprin-beta-2 isoform X6

      UniProtKB/TrEMBL
      E9PP16
      Conserved Domains (7) summary
      cd09563
      Location:497 → 560
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:571 → 633
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:656 → 727
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      smart00454
      Location:497 → 561
      SAM; Sterile alpha motif
      pfam01519
      Location:41 → 92
      DUF16; Protein of unknown function DUF16
      pfam15290
      Location:143 → 297
      Syntaphilin; Golgi-localized syntaxin-1-binding clamp
      pfam15774
      Location:252 → 401
      DUF4702; Domain of unknown function (DUF4702)

    13. XM_047427752.1 → XP_047283708.1  liprin-beta-2 isoform X7

      UniProtKB/TrEMBL
      E9PP16

    14. XM_011520418.3 → XP_011518720.1  liprin-beta-2 isoform X9

      UniProtKB/TrEMBL
      E9PP16
      Conserved Domains (7) summary
      cd09563
      Location:454 → 517
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:528 → 590
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:613 → 684
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      smart00454
      Location:454 → 518
      SAM; Sterile alpha motif
      pfam01519
      Location:12 → 49
      DUF16; Protein of unknown function DUF16
      pfam15290
      Location:100 → 254
      Syntaphilin; Golgi-localized syntaxin-1-binding clamp
      pfam15774
      Location:209 → 358
      DUF4702; Domain of unknown function (DUF4702)

    15. XM_047427753.1 → XP_047283709.1  liprin-beta-2 isoform X10

      UniProtKB/TrEMBL
      E9PP16

    16. XM_006718353.3 → XP_006718416.1  liprin-beta-2 isoform X11

      UniProtKB/TrEMBL
      E9PP16
      Conserved Domains (6) summary
      cd09563
      Location:423 → 486
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:497 → 559
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:582 → 653
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      smart00454
      Location:423 → 487
      SAM; Sterile alpha motif
      pfam15290
      Location:69 → 223
      Syntaphilin; Golgi-localized syntaxin-1-binding clamp
      pfam15774
      Location:178 → 327
      DUF4702; Domain of unknown function (DUF4702)

    17. XM_047427754.1 → XP_047283710.1  liprin-beta-2 isoform X12

      UniProtKB/TrEMBL
      E9PP16

    18. XM_047427755.1 → XP_047283711.1  liprin-beta-2 isoform X13

      UniProtKB/TrEMBL
      E9PP16

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      7572359..7725720
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054370256.1 → XP_054226231.1  liprin-beta-2 isoform X5

      UniProtKB/TrEMBL
      E9PP16

    2. XM_054370254.1 → XP_054226229.1  liprin-beta-2 isoform X3

    3. XM_054370250.1 → XP_054226225.1  liprin-beta-2 isoform X1

    4. XM_054370253.1 → XP_054226228.1  liprin-beta-2 isoform X2

    5. XM_054370249.1 → XP_054226224.1  liprin-beta-2 isoform X1

    6. XM_054370255.1 → XP_054226230.1  liprin-beta-2 isoform X4

    7. XM_054370252.1 → XP_054226227.1  liprin-beta-2 isoform X2

    8. XM_054370251.1 → XP_054226226.1  liprin-beta-2 isoform X1

    9. XM_054370259.1 → XP_054226234.1  liprin-beta-2 isoform X8

      UniProtKB/TrEMBL
      E9PP16

    10. XM_054370257.1 → XP_054226232.1  liprin-beta-2 isoform X6

      UniProtKB/TrEMBL
      E9PP16

    11. XM_054370258.1 → XP_054226233.1  liprin-beta-2 isoform X7

      UniProtKB/TrEMBL
      E9PP16

    12. XM_054370260.1 → XP_054226235.1  liprin-beta-2 isoform X9

      UniProtKB/TrEMBL
      E9PP16

    13. XM_054370261.1 → XP_054226236.1  liprin-beta-2 isoform X10

      UniProtKB/TrEMBL
      E9PP16

    14. XM_054370262.1 → XP_054226237.1  liprin-beta-2 isoform X11

      UniProtKB/TrEMBL
      E9PP16, Q68DV6

    15. XM_054370263.1 → XP_054226238.1  liprin-beta-2 isoform X12

      UniProtKB/TrEMBL
      E9PP16, Q68DV6

    16. XM_054370264.1 → XP_054226239.1  liprin-beta-2 isoform X13

      UniProtKB/TrEMBL
      E9PP16, Q68DV6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8ND30.3 GenPept UniProtKB/Swiss-Prot:Q8ND30

    Gene LinkOut

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