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    SP140 SP140 nuclear body protein [ Homo sapiens (human) ]

    Gene ID: 11262, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SP140provided by HGNC
    Official Full Name
    SP140 nuclear body proteinprovided by HGNC
    Primary source
    HGNC:HGNC:17133
    See related
    Ensembl:ENSG00000079263 MIM:608602; AllianceGenome:HGNC:17133
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LYSP100; LYSP100-A; LYSP100-B
    Summary
    This gene encodes a member of the SP100 family of proteins, which are share common domains including an N-terminal homogeneously staining region domain followed by a SP100/autoimmune regulator/NucP41/P75/deformed epidermal autoregulatory factor domain, a plant homeobox zinc finger, and a bromodomain. The encoded protein is interferon-inducible and is expressed at high levels in the nuclei of leukocytes. Variants of this gene have been associated with multiple sclerosis, Crohn's disease, and chronic lymphocytic leukemia. Alternative splicing results in multiple variants. [provided by RefSeq, Aug 2016]
    Expression
    Biased expression in lymph node (RPKM 12.2), spleen (RPKM 7.6) and 10 other tissues See more
    Orthologs
    all
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    Genomic context

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    See SP140 in Genome Data Viewer
    Location:
    2q37.1
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (230186151..230316571)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (230669263..230808985)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (231090451..231177930)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 16 member 14 Neighboring gene uncharacterized LOC107985995 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:230932348-230933118 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17207 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17208 Neighboring gene RNY4 pseudogene 19 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:231005392-231005920 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12407 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:231044589-231045131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17209 Neighboring gene SP110 nuclear body protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17210 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:231084625-231084811 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17212 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17213 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17214 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17215 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17216 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:231129497-231130018 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12408 Neighboring gene MPRA-validated peak4075 silencer Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:231176974-231178173 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17217 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17218 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:231206345-231206936 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17219 Neighboring gene SP140 nuclear body protein like Neighboring gene uncharacterized LOC105373925 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17220 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17221 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12410 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17222 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17223 Neighboring gene uncharacterized LOC101928816 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17224 Neighboring gene SP100 nuclear antigen Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17225 Neighboring gene RNA, 7SL, cytoplasmic 834, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SP140 inhibits STAT1 signaling, induces IFN-γ in tumor-associated macrophages, and is a predictive biomarker of immunotherapy response. Tanagala KKK, et al. J Immunother Cancer, 2022 Dec. PMID 36600652, Free PMC Article
    2. Identification and characterization of a leukocyte-specific component of the nuclear body. Bloch DB, et al. J Biol Chem, 1996 Nov 15. PMID 8910577
    3. PML nuclear body component Sp140 is a novel autoantigen in primary biliary cirrhosis. Granito A, et al. Am J Gastroenterol, 2010 Jan. PMID 19861957
    4. Sp140 is a multi-SUMO-1 target and its PHD finger promotes SUMOylation of the adjacent Bromodomain. Zucchelli C, et al. Biochim Biophys Acta Gen Subj, 2019 Feb. PMID 30465816
    5. SP140 regulates the expression of immune-related genes associated with multiple sclerosis and other autoimmune diseases by NF-κB inhibition. Karaky M, et al. Hum Mol Genet, 2018 Dec 1. PMID 30102396

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transcriptional regulators SP110 and SP140 modulate inflammatory response genes in Mycobacterium tuberculosis-infected human macrophages.
      Title: Transcriptional regulators SP110 and SP140 modulate inflammatory response genes in Mycobacterium tuberculosis-infected human macrophages.
    2. SP140 inhibits STAT1 signaling, induces IFN-gamma in tumor-associated macrophages, and is a predictive biomarker of immunotherapy response.
      Title: SP140 inhibits STAT1 signaling, induces IFN-γ in tumor-associated macrophages, and is a predictive biomarker of immunotherapy response.
    3. Immune chromatin reader SP140 regulates microbiota and risk for inflammatory bowel disease.
      Title: Immune chromatin reader SP140 regulates microbiota and risk for inflammatory bowel disease.
    4. Epigenetic reader SP140 loss of function drives Crohn's disease due to uncontrolled macrophage topoisomerases.
      Title: Epigenetic reader SP140 loss of function drives Crohn's disease due to uncontrolled macrophage topoisomerases.
    5. The Sp140 is multi-SUMOylated and its PHD finger works as versatile protein-protein interaction platform promoting intramolecular SUMOylation of the adjacent BRD.
      Title: Sp140 is a multi-SUMO-1 target and its PHD finger promotes SUMOylation of the adjacent Bromodomain.
    6. Our findings showed that SP140 is an important repressor of genes implicated in inflammation, suggesting that decreased expression of SP140, promoted by the rs28445040-T risk variant, may lead to up-regulation of these genes by means of NF-kappaB inhibition in B cells.
      Title: SP140 regulates the expression of immune-related genes associated with multiple sclerosis and other autoimmune diseases by NF-κB inhibition.
    7. IL1R2 hypomethylation and androgen receptor hypermethylation may constitute an important determinant of disease severity, whereas NPR2 hypomethylation and SP140 hypermethylation may provide a biomarker for vulnerability to excessive daytime sleepiness in Obstructive Sleep Apnea
      Title: Whole Genome DNA Methylation Analysis of Obstructive Sleep Apnea: IL1R2, NPR2, AR, SP140 Methylation and Clinical Phenotype.
    8. Data identified rs28445040 variant in SP140 gene as the causal factor for skipping of exon 7 and the most associated with multiple sclerosis.
      Title: A functional variant that affects exon-skipping and protein expression of SP140 as genetic mechanism predisposing to multiple sclerosis.
    9. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic susceptibility for chronic lymphocytic leukemia among Chinese in Hong Kong.
    10. the nuclear body protein Sp140, was found specifically in all NP cells (n = 12 cell lines tested; P < or = 0.001), and HIV-1 infection induced its partial dispersal from nuclear bodies into cytosolic colocalization with Vif
      Title: Implication of the lymphocyte-specific nuclear body protein Sp140 in an innate response to human immunodeficiency virus type 1.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
    EBI GWAS Catalog
    A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.
    EBI GWAS Catalog
    Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia.
    EBI GWAS Catalog
    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    EBI GWAS Catalog
    Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
    EBI GWAS Catalog
    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif Wild-type HIV-1 Vif binds to the carboxyl-terminal region of Sp140 between amino acids 527-836, while Vif mutants with deletions of amino acids 12-23, 43-59, 73-87 or 97-112 are strongly inhibited in their binding to Sp140 PubMed
    vif HIV-1 Vif may enhance the cytosolic retention of Sp140 PubMed
    vif Specific binding of HIV-1 Vif to Sp140 was identified using a yeast two-hybrid screen of a human lymphocyte cDNA library and verified by co-immunoprecipitation PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC126440

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in PML body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center IDA
    Inferred from Direct Assay
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nuclear body protein SP140
    Names
    lymphoid-restricted homolog of Sp100
    lymphoid-specific SP100 homolog
    nuclear autoantigen Sp-140
    speckled 140 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051286.2 RefSeqGene

      Range
      44587..132066
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001005176.3 → NP_001005176.1  nuclear body protein SP140 isoform 2

      See identical proteins and their annotated locations for NP_001005176.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks multiple 3' exons, and has an alternate 3' sequence, as compared to variant 1. The encoded isoform 2 is much shorter and has a distinct C-terminus, as compared to isoform 1.
      Source sequence(s)
      AA741304, AK301267, BC070160
      Consensus CDS
      CCDS33392.1
      UniProtKB/Swiss-Prot
      Q13342
      UniProtKB/TrEMBL
      B4DVW8
      Related
      ENSP00000362749.3, ENST00000373645.3
      Conserved Domains (1) summary
      pfam03172
      Location:42 → 135
      Sp100; Sp100 domain

    2. NM_001278451.2 → NP_001265380.1  nuclear body protein SP140 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC009949, BC105960, DC391925, U36499
      Consensus CDS
      CCDS63150.1
      UniProtKB/TrEMBL
      Q0VGE4
      Related
      ENSP00000398210.3, ENST00000420434.7
      Conserved Domains (4) summary
      cd05501
      Location:730 → 833
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      cd15626
      Location:665 → 706
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:558 → 633
      SAND; SAND domain
      pfam03172
      Location:42 → 135
      Sp100; Sp100 domain

    3. NM_001278452.2 → NP_001265381.1  nuclear body protein SP140 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC009949, BC105744, DC391925, U36499
      Consensus CDS
      CCDS63151.1
      UniProtKB/TrEMBL
      Q0VGE4
      Related
      ENSP00000342096.6, ENST00000343805.10
      Conserved Domains (5) summary
      cd05501
      Location:697 → 800
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      PHA03169
      Location:202 → 419
      PHA03169; hypothetical protein; Provisional
      cd15626
      Location:632 → 673
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:525 → 600
      SAND; SAND domain
      pfam03172
      Location:42 → 135
      Sp100; Sp100 domain

    4. NM_001278453.2 → NP_001265382.1  nuclear body protein SP140 isoform 5

      See identical proteins and their annotated locations for NP_001265382.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks three alternate in-frame exons and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC009949, AC009950, DC391925, U36499, U63420
      Consensus CDS
      CCDS63149.1
      UniProtKB/TrEMBL
      Q0VGE4
      Related
      ENSP00000393618.3, ENST00000417495.7
      Conserved Domains (4) summary
      cd05501
      Location:643 → 746
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      cd15626
      Location:578 → 619
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:471 → 546
      SAND; SAND domain
      pfam03172
      Location:42 → 135
      Sp100; Sp100 domain

    5. NM_007237.5 → NP_009168.4  nuclear body protein SP140 isoform 1

      See identical proteins and their annotated locations for NP_009168.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC009949, AK301267, BC038091, BC105960, U36500
      Consensus CDS
      CCDS42831.1
      UniProtKB/Swiss-Prot
      E7ESH9, E7EUR5, E9PFJ6, Q0VGE5, Q13341, Q13342, Q3KR17, Q4ZG66, Q53TG1, Q6NSG4, Q92881, Q96TG3
      UniProtKB/TrEMBL
      Q0VGE4
      Related
      ENSP00000375899.3, ENST00000392045.8
      Conserved Domains (4) summary
      cd05501
      Location:757 → 860
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      cd15626
      Location:692 → 733
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:585 → 660
      SAND; SAND domain
      pfam03172
      Location:42 → 135
      Sp100; Sp100 domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      230186151..230316571
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047443073.1 → XP_047299029.1  nuclear body protein SP140 isoform X7

      UniProtKB/TrEMBL
      Q0VGE4

    2. XM_011510517.4 → XP_011508819.1  nuclear body protein SP140 isoform X7

      See identical proteins and their annotated locations for XP_011508819.1

      UniProtKB/TrEMBL
      Q0VGE4
      Conserved Domains (4) summary
      cd05501
      Location:737 → 840
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      cd15626
      Location:672 → 713
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:565 → 640
      SAND; SAND domain
      pfam03172
      Location:22 → 115
      Sp100; Sp100 domain

    3. XM_006712223.4 → XP_006712286.1  nuclear body protein SP140 isoform X1

      UniProtKB/TrEMBL
      B4DVW8
      Conserved Domains (4) summary
      cd15626
      Location:692 → 733
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:585 → 660
      SAND; SAND domain
      pfam03172
      Location:42 → 135
      Sp100; Sp100 domain
      cl02556
      Location:757 → 838
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

    4. XM_047443077.1 → XP_047299033.1  nuclear body protein SP140 isoform X21

      UniProtKB/TrEMBL
      B4DVW8

    5. XM_011510518.3 → XP_011508820.1  nuclear body protein SP140 isoform X7

      See identical proteins and their annotated locations for XP_011508820.1

      UniProtKB/TrEMBL
      Q0VGE4
      Conserved Domains (4) summary
      cd05501
      Location:737 → 840
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      cd15626
      Location:672 → 713
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:565 → 640
      SAND; SAND domain
      pfam03172
      Location:22 → 115
      Sp100; Sp100 domain

    6. XM_011510516.2 → XP_011508818.1  nuclear body protein SP140 isoform X5

      UniProtKB/TrEMBL
      Q0VGE4
      Conserved Domains (4) summary
      cd05501
      Location:748 → 851
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      cd15626
      Location:692 → 726
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:585 → 660
      SAND; SAND domain
      pfam03172
      Location:42 → 135
      Sp100; Sp100 domain

    7. XM_011510515.2 → XP_011508817.1  nuclear body protein SP140 isoform X3

      UniProtKB/TrEMBL
      Q0VGE4
      Conserved Domains (4) summary
      cd05501
      Location:751 → 854
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      cd15626
      Location:686 → 727
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:579 → 654
      SAND; SAND domain
      pfam03172
      Location:42 → 135
      Sp100; Sp100 domain

    8. XM_005246254.3 → XP_005246311.1  nuclear body protein SP140 isoform X13

      UniProtKB/TrEMBL
      Q0VGE4
      Conserved Domains (4) summary
      cd05501
      Location:723 → 826
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      cd15626
      Location:658 → 699
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:551 → 626
      SAND; SAND domain
      pfam03172
      Location:42 → 135
      Sp100; Sp100 domain

    9. XM_011510519.2 → XP_011508821.1  nuclear body protein SP140 isoform X9

      UniProtKB/TrEMBL
      Q0VGE4
      Conserved Domains (4) summary
      cd05501
      Location:730 → 833
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      cd15626
      Location:665 → 706
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:558 → 633
      SAND; SAND domain
      pfam03172
      Location:42 → 135
      Sp100; Sp100 domain

    10. XM_005246256.3 → XP_005246313.1  nuclear body protein SP140 isoform X20

      UniProtKB/TrEMBL
      Q0VGE4
      Conserved Domains (4) summary
      cd05501
      Location:696 → 799
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      cd15626
      Location:631 → 672
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:524 → 599
      SAND; SAND domain
      pfam03172
      Location:42 → 135
      Sp100; Sp100 domain

    11. XM_047443078.1 → XP_047299034.1  nuclear body protein SP140 isoform X24

      UniProtKB/TrEMBL
      Q0VGE4

    12. XM_005246255.3 → XP_005246312.1  nuclear body protein SP140 isoform X16

      UniProtKB/TrEMBL
      B4DVW8
      Conserved Domains (4) summary
      cd05501
      Location:707 → 810
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      cd15626
      Location:642 → 683
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:535 → 610
      SAND; SAND domain
      pfam03172
      Location:42 → 135
      Sp100; Sp100 domain

    13. XM_047443076.1 → XP_047299032.1  nuclear body protein SP140 isoform X19

      UniProtKB/TrEMBL
      B4DVW8

    14. XM_017003252.2 → XP_016858741.1  nuclear body protein SP140 isoform X28

      UniProtKB/TrEMBL
      Q0VGE4

    15. XM_005246253.3 → XP_005246310.1  nuclear body protein SP140 isoform X8

      UniProtKB/TrEMBL
      Q0VGE4
      Conserved Domains (5) summary
      cd05501
      Location:731 → 834
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      PHA03169
      Location:202 → 453
      PHA03169; hypothetical protein; Provisional
      cd15626
      Location:666 → 707
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:559 → 634
      SAND; SAND domain
      pfam03172
      Location:42 → 135
      Sp100; Sp100 domain

    16. XM_017003240.2 → XP_016858729.1  nuclear body protein SP140 isoform X12

      UniProtKB/TrEMBL
      Q0VGE4

    17. XM_017003249.2 → XP_016858738.1  nuclear body protein SP140 isoform X26

      UniProtKB/TrEMBL
      Q0VGE4

    18. XM_005246252.3 → XP_005246309.1  nuclear body protein SP140 isoform X2

      UniProtKB/TrEMBL
      Q0VGE4
      Conserved Domains (4) summary
      cd05501
      Location:754 → 857
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      cd15626
      Location:689 → 730
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:582 → 657
      SAND; SAND domain
      pfam03172
      Location:42 → 135
      Sp100; Sp100 domain

    19. XM_047443072.1 → XP_047299028.1  nuclear body protein SP140 isoform X6

      UniProtKB/TrEMBL
      Q0VGE4

    20. XM_017003239.2 → XP_016858728.1  nuclear body protein SP140 isoform X4

      UniProtKB/TrEMBL
      Q0VGE4

    21. XM_017003243.2 → XP_016858732.1  nuclear body protein SP140 isoform X15

      UniProtKB/TrEMBL
      Q0VGE4

    22. XM_047443074.1 → XP_047299030.1  nuclear body protein SP140 isoform X11

      UniProtKB/TrEMBL
      Q0VGE4

    23. XM_017003248.2 → XP_016858737.1  nuclear body protein SP140 isoform X23

      UniProtKB/TrEMBL
      Q0VGE4

    24. XM_047443079.1 → XP_047299035.1  nuclear body protein SP140 isoform X25

      UniProtKB/TrEMBL
      Q0VGE4

    25. XM_017003245.2 → XP_016858734.1  nuclear body protein SP140 isoform X17

      UniProtKB/TrEMBL
      B4DVW8

    26. XM_011510520.2 → XP_011508822.1  nuclear body protein SP140 isoform X10

      UniProtKB/TrEMBL
      Q0VGE4
      Conserved Domains (4) summary
      cd05501
      Location:728 → 831
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      cd15626
      Location:663 → 704
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:556 → 631
      SAND; SAND domain
      pfam03172
      Location:42 → 135
      Sp100; Sp100 domain

    27. XM_017003242.2 → XP_016858731.1  nuclear body protein SP140 isoform X14

      UniProtKB/TrEMBL
      Q0VGE4

    28. XM_017003247.2 → XP_016858736.1  nuclear body protein SP140 isoform X22

      UniProtKB/TrEMBL
      Q0VGE4

    29. XM_017003246.2 → XP_016858735.1  nuclear body protein SP140 isoform X18

      UniProtKB/TrEMBL
      Q0VGE4

    30. XM_017003250.2 → XP_016858739.1  nuclear body protein SP140 isoform X27

      UniProtKB/TrEMBL
      Q0VGE4

    31. XM_047443080.1 → XP_047299036.1  nuclear body protein SP140 isoform X29

    32. XM_047443081.1 → XP_047299037.1  nuclear body protein SP140 isoform X31

    33. XM_017003253.2 → XP_016858742.1  nuclear body protein SP140 isoform X30

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      230669263..230808985
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340304.1 → XP_054196279.1  nuclear body protein SP140 isoform X7

      UniProtKB/TrEMBL
      Q0VGE4

    2. XM_054340302.1 → XP_054196277.1  nuclear body protein SP140 isoform X7

      UniProtKB/TrEMBL
      Q0VGE4

    3. XM_054340296.1 → XP_054196271.1  nuclear body protein SP140 isoform X1

      UniProtKB/TrEMBL
      B4DVW8

    4. XM_054340318.1 → XP_054196293.1  nuclear body protein SP140 isoform X21

      UniProtKB/TrEMBL
      Q0VGE4

    5. XM_054340303.1 → XP_054196278.1  nuclear body protein SP140 isoform X7

      UniProtKB/TrEMBL
      Q0VGE4

    6. XM_054340300.1 → XP_054196275.1  nuclear body protein SP140 isoform X5

      UniProtKB/TrEMBL
      Q0VGE4

    7. XM_054340298.1 → XP_054196273.1  nuclear body protein SP140 isoform X3

      UniProtKB/TrEMBL
      Q0VGE4

    8. XM_054340310.1 → XP_054196285.1  nuclear body protein SP140 isoform X13

      UniProtKB/TrEMBL
      Q0VGE4

    9. XM_054340306.1 → XP_054196281.1  nuclear body protein SP140 isoform X9

      UniProtKB/TrEMBL
      Q0VGE4

    10. XM_054340317.1 → XP_054196292.1  nuclear body protein SP140 isoform X20

      UniProtKB/TrEMBL
      Q0VGE4

    11. XM_054340321.1 → XP_054196296.1  nuclear body protein SP140 isoform X24

      UniProtKB/TrEMBL
      Q0VGE4

    12. XM_054340313.1 → XP_054196288.1  nuclear body protein SP140 isoform X16

      UniProtKB/TrEMBL
      B4DVW8

    13. XM_054340316.1 → XP_054196291.1  nuclear body protein SP140 isoform X19

      UniProtKB/TrEMBL
      B4DVW8

    14. XM_054340325.1 → XP_054196300.1  nuclear body protein SP140 isoform X28

      UniProtKB/TrEMBL
      Q0VGE4

    15. XM_054340305.1 → XP_054196280.1  nuclear body protein SP140 isoform X8

      UniProtKB/TrEMBL
      Q0VGE4

    16. XM_054340309.1 → XP_054196284.1  nuclear body protein SP140 isoform X12

      UniProtKB/TrEMBL
      Q0VGE4

    17. XM_054340323.1 → XP_054196298.1  nuclear body protein SP140 isoform X26

      UniProtKB/TrEMBL
      Q0VGE4

    18. XM_054340297.1 → XP_054196272.1  nuclear body protein SP140 isoform X2

      UniProtKB/TrEMBL
      Q0VGE4

    19. XM_054340301.1 → XP_054196276.1  nuclear body protein SP140 isoform X6

      UniProtKB/TrEMBL
      Q0VGE4

    20. XM_054340299.1 → XP_054196274.1  nuclear body protein SP140 isoform X4

      UniProtKB/TrEMBL
      Q0VGE4

    21. XM_054340312.1 → XP_054196287.1  nuclear body protein SP140 isoform X15

      UniProtKB/TrEMBL
      Q0VGE4

    22. XM_054340308.1 → XP_054196283.1  nuclear body protein SP140 isoform X11

      UniProtKB/TrEMBL
      Q0VGE4

    23. XM_054340320.1 → XP_054196295.1  nuclear body protein SP140 isoform X23

      UniProtKB/TrEMBL
      Q0VGE4

    24. XM_054340322.1 → XP_054196297.1  nuclear body protein SP140 isoform X25

      UniProtKB/TrEMBL
      Q0VGE4

    25. XM_054340314.1 → XP_054196289.1  nuclear body protein SP140 isoform X17

      UniProtKB/TrEMBL
      B4DVW8

    26. XM_054340307.1 → XP_054196282.1  nuclear body protein SP140 isoform X10

      UniProtKB/TrEMBL
      Q0VGE4

    27. XM_054340311.1 → XP_054196286.1  nuclear body protein SP140 isoform X14

      UniProtKB/TrEMBL
      Q0VGE4

    28. XM_054340319.1 → XP_054196294.1  nuclear body protein SP140 isoform X22

      UniProtKB/TrEMBL
      Q0VGE4

    29. XM_054340315.1 → XP_054196290.1  nuclear body protein SP140 isoform X18

      UniProtKB/TrEMBL
      Q0VGE4

    30. XM_054340324.1 → XP_054196299.1  nuclear body protein SP140 isoform X27

      UniProtKB/TrEMBL
      Q0VGE4

    31. XM_054340326.1 → XP_054196301.1  nuclear body protein SP140 isoform X29

    32. XM_054340328.1 → XP_054196303.1  nuclear body protein SP140 isoform X31

    33. XM_054340327.1 → XP_054196302.1  nuclear body protein SP140 isoform X30

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13342.2 GenPept UniProtKB/Swiss-Prot:Q13342

    Gene LinkOut

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