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    TATDN1 TatD DNase domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 83940, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TATDN1provided by HGNC
    Official Full Name
    TatD DNase domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:24220
    See related
    Ensembl:ENSG00000147687 MIM:619364; AllianceGenome:HGNC:24220
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDA11
    Summary
    Predicted to enable 3'-5'-DNA exonuclease activity. Predicted to be involved in DNA metabolic process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 16.0), ovary (RPKM 13.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TATDN1 in Genome Data Viewer
    Location:
    8q24.13
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (124488494..124539088, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (125621522..125672104, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (125500735..125551329, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:125483735-125484236 Neighboring gene RNF139 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27882 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:125486486-125487030 Neighboring gene tRNA methyltransferase 12 homolog Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:125487031-125487576 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:125487577-125488120 Neighboring gene ring finger protein 139 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27884 Neighboring gene microRNA 6844 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27885 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27886 Neighboring gene NADH:ubiquinone oxidoreductase subunit B9 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19514 Neighboring gene uncharacterized LOC105375740 Neighboring gene MTSS I-BAR domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LncRNA TATDN1 contributes to the cisplatin resistance of non-small cell lung cancer through TATDN1/miR-451/TRIM66 axis. Wang L, et al. Cancer Biol Ther, 2019. PMID 30481109, Free PMC Article
    2. The role and potential mechanisms of LncRNA-TATDN1 on metastasis and invasion of non-small cell lung cancer. Zequn N, et al. Oncotarget, 2016 Apr 5. PMID 26943769, Free PMC Article
    3. Human and bacterial TatD enzymes exhibit apurinic/apyrimidinic (AP) endonuclease activity. Dorival J, et al. Nucleic Acids Res, 2023 Apr 11. PMID 36881763, Free PMC Article
    4. The DNase domain-containing protein TATDN1 plays an important role in chromosomal segregation and cell cycle progression during zebrafish eye development. Yang H, et al. Cell Cycle, 2012 Dec 15. PMID 23187801, Free PMC Article
    5. The gene expression profiling of sporadic pheochromocytoma and novel full-length cDNAs cloning. Yang YS, et al. Endocr Relat Cancer, 2003 Dec. PMID 14713272

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Human and bacterial TatD enzymes exhibit apurinic/apyrimidinic (AP) endonuclease activity.
      Title: Human and bacterial TatD enzymes exhibit apurinic/apyrimidinic (AP) endonuclease activity.
    2. TATDN1 promotes the development and progression of breast cancer by targeting microRNA-140-3p.
      Title: TATDN1 promotes the development and progression of breast cancer by targeting microRNA-140-3p.
    3. LncRNA TATDN1 induces the progression of hepatocellular carcinoma via targeting miRNA-6089.
      Title: LncRNA TATDN1 induces the progression of hepatocellular carcinoma via targeting miRNA-6089.
    4. TATDN1 enhanced the DDP-tolerance of NSCLC cells by upregulating TRIM66 expression via sponging miR-451, hinting a novel regulatory pathway of chemoresistance in DDP-tolerant NSCLC cells.
      Title: LncRNA TATDN1 contributes to the cisplatin resistance of non-small cell lung cancer through TATDN1/miR-451/TRIM66 axis.
    5. The data indicate that TATDN1 expression is associated with 95D cells' higher potential of invasion and metastasis, and suggest that TATDN1 may be a potential prognostic factor and therapeutic target for non-small cell lung cancer.
      Title: The role and potential mechanisms of LncRNA-TATDN1 on metastasis and invasion of non-small cell lung cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of TatD DNase domain containing 1 (TATDN1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ43280

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3'-5'-DNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HTP PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    deoxyribonuclease TATDN1
    Names
    hepatocarcinoma high expression protein
    putative deoxyribonuclease TATDN1
    NP_001139632.1
    NP_001304818.1
    NP_001304819.1
    NP_001304820.1
    NP_114415.1
    XP_006716729.1
    XP_006716732.1
    XP_011515633.1
    XP_016869384.1
    XP_016869386.1
    XP_016869388.1
    XP_024303061.1
    XP_047278256.1
    XP_047278257.1
    XP_047278258.1
    XP_054189019.1
    XP_054189020.1
    XP_054189021.1
    XP_054189022.1
    XP_054189023.1
    XP_054189024.1
    XP_054189025.1
    XP_054189026.1
    XP_054189027.1
    XP_054189028.1
    XP_054217316.1
    XP_054217317.1
    XP_054217318.1
    XP_054217319.1
    XP_054217320.1
    XP_054217321.1
    XP_054217322.1
    XP_054217323.1
    XP_054217324.1
    XP_054217325.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146160.1 → NP_001139632.1  deoxyribonuclease TATDN1 isoform b

      See identical proteins and their annotated locations for NP_001139632.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences compared to variant 4. These differences cause translation initiation at a downstream AUG and result in an isoform (b) that is shorter than isoform c.
      Source sequence(s)
      AF212250, AV729364, AY071865, BC007066
      Consensus CDS
      CCDS55273.1
      UniProtKB/Swiss-Prot
      Q6P1N9
      Related
      ENSP00000428336.1, ENST00000519548.5
      Conserved Domains (1) summary
      cd01310
      Location:1 → 247
      TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

    2. NM_001317889.1 → NP_001304818.1  deoxyribonuclease TATDN1 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (c).
      Source sequence(s)
      AV729364, BC007066, BU784642, BX332564
      UniProtKB/TrEMBL
      E5RG17
      Related
      ENSP00000430274.1, ENST00000522810.5
      Conserved Domains (1) summary
      cd01310
      Location:6 → 330
      TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

    3. NM_001317890.1 → NP_001304819.1  deoxyribonuclease TATDN1 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has multiple differences compared to variant 4. These differences cause translation initiation at a downstream AUG and result in an isoform (d) that is shorter than isoform c.
      Source sequence(s)
      AV729364, AY071865, BC007066, BG532054
      Consensus CDS
      CCDS83323.1
      UniProtKB/TrEMBL
      A0A0D9SGD3, E5RGF2
      Related
      ENSP00000487380.1, ENST00000630259.1
      Conserved Domains (1) summary
      cd01310
      Location:14 → 240
      TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

    4. NM_001317891.1 → NP_001304820.1  deoxyribonuclease TATDN1 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) has multiple differences compared to variant 4. These differences cause translation initiation at a downstream AUG and result in an isoform (e) that is shorter than isoform c.
      Source sequence(s)
      AV729364, AY071865, BC007066, BG529611
      UniProtKB/Swiss-Prot
      Q6P1N9
      Conserved Domains (1) summary
      cl00281
      Location:1 → 149
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

    5. NM_032026.4 → NP_114415.1  deoxyribonuclease TATDN1 isoform a

      See identical proteins and their annotated locations for NP_114415.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate in-frame splice site and lacks an alternate exon in the 3' coding region compared to variant 4. The encoded isoform (a) is shorter than isoform c.
      Source sequence(s)
      AF212250, AV729364, BC007066, BC064964
      Consensus CDS
      CCDS6351.1
      UniProtKB/Swiss-Prot
      B2R5J0, Q6P1N9, Q8TD02, Q9BY40
      UniProtKB/TrEMBL
      E5RG17
      Related
      ENSP00000276692.6, ENST00000276692.11
      Conserved Domains (1) summary
      cd01310
      Location:6 → 294
      TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

    RNA

    1. NR_027427.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in an internal exon compared to variant 4. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC090198, AF212250, AV729364, BC007066
      Related
      ENST00000523214.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      124488494..124539088 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011517331.4 → XP_011515633.1  deoxyribonuclease TATDN1 isoform X2

      UniProtKB/TrEMBL
      E5RG17
      Conserved Domains (1) summary
      cd01310
      Location:5 → 308
      TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

    2. XM_024447293.2 → XP_024303061.1  deoxyribonuclease TATDN1 isoform X6

      UniProtKB/TrEMBL
      E5RG17
      Conserved Domains (1) summary
      cd01310
      Location:5 → 272
      TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

    3. XM_006716666.5 → XP_006716729.1  deoxyribonuclease TATDN1 isoform X1

      UniProtKB/TrEMBL
      E5RG17
      Conserved Domains (1) summary
      cd01310
      Location:13 → 314
      TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

    4. XM_017013895.3 → XP_016869384.1  deoxyribonuclease TATDN1 isoform X5

      UniProtKB/TrEMBL
      E5RG17

    5. XM_047422301.1 → XP_047278257.1  deoxyribonuclease TATDN1 isoform X4

      UniProtKB/TrEMBL
      E5RG17

    6. XM_006716669.4 → XP_006716732.1  deoxyribonuclease TATDN1 isoform X3

      See identical proteins and their annotated locations for XP_006716732.1

      UniProtKB/TrEMBL
      E5RG17
      Conserved Domains (1) summary
      cd01310
      Location:21 → 297
      TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

    7. XM_047422302.1 → XP_047278258.1  deoxyribonuclease TATDN1 isoform X9

    8. XM_047422300.1 → XP_047278256.1  deoxyribonuclease TATDN1 isoform X3

      UniProtKB/TrEMBL
      E5RG17

    9. XM_017013897.3 → XP_016869386.1  deoxyribonuclease TATDN1 isoform X7

      Conserved Domains (1) summary
      cd01310
      Location:21 → 261
      TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

    10. XM_017013899.2 → XP_016869388.1  deoxyribonuclease TATDN1 isoform X8

      UniProtKB/TrEMBL
      G5EA19
      Related
      ENSP00000476180.1, ENST00000605953.5

    RNA

    1. XR_007060756.1 RNA Sequence

      Related
      ENST00000519776.5

    2. XR_007060757.1 RNA Sequence

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791784.1 Reference GRCh38.p14 PATCHES

      Range
      23444..74038 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333045.1 → XP_054189020.1  deoxyribonuclease TATDN1 isoform X2

      UniProtKB/TrEMBL
      E5RG17

    2. XM_054333050.1 → XP_054189025.1  deoxyribonuclease TATDN1 isoform X6

      UniProtKB/TrEMBL
      E5RG17

    3. XM_054333044.1 → XP_054189019.1  deoxyribonuclease TATDN1 isoform X1

      UniProtKB/TrEMBL
      E5RG17

    4. XM_054333049.1 → XP_054189024.1  deoxyribonuclease TATDN1 isoform X5

      UniProtKB/TrEMBL
      E5RG17

    5. XM_054333048.1 → XP_054189023.1  deoxyribonuclease TATDN1 isoform X4

      UniProtKB/TrEMBL
      E5RG17

    6. XM_054333047.1 → XP_054189022.1  deoxyribonuclease TATDN1 isoform X3

      UniProtKB/TrEMBL
      E5RG17

    7. XM_054333053.1 → XP_054189028.1  deoxyribonuclease TATDN1 isoform X9

    8. XM_054333046.1 → XP_054189021.1  deoxyribonuclease TATDN1 isoform X3

      UniProtKB/TrEMBL
      E5RG17

    9. XM_054333051.1 → XP_054189026.1  deoxyribonuclease TATDN1 isoform X7

    10. XM_054333052.1 → XP_054189027.1  deoxyribonuclease TATDN1 isoform X8

      UniProtKB/TrEMBL
      G5EA19

    RNA

    1. XR_008485817.1 RNA Sequence

    2. XR_008485818.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      125621522..125672104 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361342.1 → XP_054217317.1  deoxyribonuclease TATDN1 isoform X2

      UniProtKB/TrEMBL
      E5RG17

    2. XM_054361347.1 → XP_054217322.1  deoxyribonuclease TATDN1 isoform X6

      UniProtKB/TrEMBL
      E5RG17

    3. XM_054361341.1 → XP_054217316.1  deoxyribonuclease TATDN1 isoform X1

      UniProtKB/TrEMBL
      E5RG17

    4. XM_054361346.1 → XP_054217321.1  deoxyribonuclease TATDN1 isoform X5

      UniProtKB/TrEMBL
      E5RG17

    5. XM_054361345.1 → XP_054217320.1  deoxyribonuclease TATDN1 isoform X4

      UniProtKB/TrEMBL
      E5RG17

    6. XM_054361344.1 → XP_054217319.1  deoxyribonuclease TATDN1 isoform X3

      UniProtKB/TrEMBL
      E5RG17

    7. XM_054361350.1 → XP_054217325.1  deoxyribonuclease TATDN1 isoform X9

    8. XM_054361343.1 → XP_054217318.1  deoxyribonuclease TATDN1 isoform X3

      UniProtKB/TrEMBL
      E5RG17

    9. XM_054361348.1 → XP_054217323.1  deoxyribonuclease TATDN1 isoform X7

    10. XM_054361349.1 → XP_054217324.1  deoxyribonuclease TATDN1 isoform X8

      UniProtKB/TrEMBL
      G5EA19

    RNA

    1. XR_008487883.1 RNA Sequence

    2. XR_008487884.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P1N9.2 GenPept UniProtKB/Swiss-Prot:Q6P1N9

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