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Links from PubChem Compound
- Official
Symbol
- CES1provided by HGNC
- Official
Full Name
- carboxylesterase 1provided by HGNC
- Primary source
-
HGNC:HGNC:1863
- See related
-
Ensembl:ENSG00000198848
MIM:114835;
AllianceGenome:HGNC:1863
- Gene type
- protein coding
- RefSeq status
- REVIEWED
- Organism
-
Homo sapiens
- Lineage
- Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
- Also known as
- CEH; REH; TGH; ACAT; CE-1; CES2; HMSE; SES1; HMSE1; PCE-1; hCE-1
- Summary
- This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
- Expression
- Biased expression in liver (RPKM 737.7), gall bladder (RPKM 239.9) and 3 other tissues See more
- Orthologs
-
all
-
NEW
-
Try the new Gene table
Try the new Transcript table
- Exon count:
- 14
Annotation release |
Status |
Assembly |
Chr
|
Location |
RS_2024_08 |
current |
GRCh38.p14 (GCF_000001405.40) |
16 |
NC_000016.10 (55802851..55833096, complement) |
RS_2024_08 |
current |
T2T-CHM13v2.0 (GCF_009914755.1) |
16 |
NC_060940.1 (61597797..61628094, complement) |
105.20220307 |
previous assembly |
GRCh37.p13 (GCF_000001405.25) |
16 |
NC_000016.9 (55836763..55867008, complement) |
Chromosome 16 - NC_000016.10
- Project title: HPA RNA-seq normal tissues
HPA RNA-seq normal tissues
- Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
- BioProject: PRJEB4337
- Publication:
PMID 24309898
- Analysis date: Wed Apr 4 07:08:55 2018
-
The Influence of Structural Variants of the CES1 Gene on the Pharmacokinetics of Enalapril, Presumably Due to Linkage Disequilibrium with the Intronic rs2244613.
Ikonnikova A, et al. Genes (Basel), 2022 Nov 27. PMID 36553492, Free PMC Article
-
Identification of regulatory variants of carboxylesterase 1 (CES1): A proof-of-concept study for the application of the Allele-Specific Protein Expression (ASPE) assay in identifying cis-acting regulatory genetic polymorphisms.
Her L, et al. Proteomics, 2023 Jan. PMID 36413357, Free PMC Article
-
Carboxylesterase-1 Assisted Targeting of HDAC Inhibitors to Mononuclear Myeloid Cells in Inflammatory Bowel Disease.
Elfiky AMI, et al. J Crohns Colitis, 2022 May 10. PMID 34633041, Free PMC Article
-
Copy number variation in the CES1 gene and the risk of non-alcoholic fatty liver in a Chinese Han population.
Chen BB, et al. Sci Rep, 2021 Jul 7. PMID 34234263, Free PMC Article
-
Melatonin inhibits lipid accumulation to repress prostate cancer progression by mediating the epigenetic modification of CES1.
Zhou L, et al. Clin Transl Med, 2021 Jun. PMID 34185414, Free PMC Article
See all (132) citations in PubMed
Products |
Interactant |
Other Gene |
Complex |
Source |
Pubs |
Description |
- Preferred Names
- liver carboxylesterase 1
- Names
- acyl coenzyme A:cholesterol acyltransferase
- brain carboxylesterase hBr1
- carboxylesterase 1 (monocyte/macrophage serine esterase 1)
- carboxylesterase 2 (liver)
- cholesteryl ester hydrolase
- cocaine carboxylesterase
- egasyn
- human monocyte/macrophage serine esterase 1
- methylumbelliferyl-acetate deacetylase 1
- monocyte/macrophage serine esterase
- retinyl ester hydrolase
- serine esterase 1
- triacylglycerol hydrolase
- NP_001020365.1
-
- NP_001020366.1
-
- NP_001257.4
-
- XP_005255831.1
-
- XP_054185552.1
-
- XP_054235372.1
-
NEW
Try the new Transcript table
These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_012057.1 RefSeqGene
- Range
-
5068..35313
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001025194.2 → NP_001020365.1 liver carboxylesterase 1 isoform b precursor
See identical proteins and their annotated locations for NP_001020365.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) uses a different in-frame splice site at the end of a coding exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter by 1 aa compared to isoform a.
- Source sequence(s)
-
AB119995, AU139632, BC012418
- Consensus CDS
-
CCDS45488.1
- UniProtKB/Swiss-Prot
- A6NIM1, A8K3K8, A8K844, E9PAU8, P23141, P82127, Q00015, Q13657, Q14062, Q16737, Q16788, Q549X7, Q549X8, Q86UK2, Q96EE8, Q9UC52, Q9UDG8, Q9UK77, Q9ULY2
- Related
- ENSP00000355193.4, ENST00000361503.8
- Conserved Domains (2) summary
-
- COG0657
Location:121 → 239
- Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
- pfam00135
Location:24 → 547
- COesterase; Carboxylesterase family
-
NM_001025195.2 → NP_001020366.1 liver carboxylesterase 1 isoform a precursor
See identical proteins and their annotated locations for NP_001020366.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
- Source sequence(s)
-
AU139632, BC012418, CB137639, L07764
- Consensus CDS
-
CCDS32450.1
- UniProtKB/Swiss-Prot
-
P23141
- Related
- ENSP00000353720.4, ENST00000360526.8
- Conserved Domains (2) summary
-
- COG0657
Location:122 → 240
- Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
- pfam00135
Location:25 → 548
- COesterase; Carboxylesterase family
-
NM_001266.5 → NP_001257.4 liver carboxylesterase 1 isoform c precursor
See identical proteins and their annotated locations for NP_001257.4
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) uses a different in-frame splice site at the end of two separate exons compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter by 2 aa compared to isoform a.
- Source sequence(s)
-
AU139632, BC012418, L07765
- Consensus CDS
-
CCDS45489.1
- UniProtKB/Swiss-Prot
-
P23141
- Related
- ENSP00000390492.2, ENST00000422046.6
- Conserved Domains (2) summary
-
- COG0657
Location:121 → 239
- Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
- pfam00135
Location:24 → 546
- COesterase; Carboxylesterase family
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000016.10 Reference GRCh38.p14 Primary Assembly
- Range
-
55802851..55833096 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_005255774.3 → XP_005255831.1 liver carboxylesterase 1 isoform X1
- Conserved Domains (2) summary
-
- COG0657
Location:122 → 240
- Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
- pfam00135
Location:25 → 547
- COesterase; Carboxylesterase family
Reference GRCh38.p14 ALT_REF_LOCI_1
Genomic
-
NW_003315945.1 Reference GRCh38.p14 ALT_REF_LOCI_1
- Range
-
26724..57001 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054329577.1 → XP_054185552.1 liver carboxylesterase 1 isoform X1
Alternate T2T-CHM13v2.0
Genomic
-
NC_060940.1 Alternate T2T-CHM13v2.0
- Range
-
61597797..61628094 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054379397.1 → XP_054235372.1 liver carboxylesterase 1 isoform X1
The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.
Molecular Biology Databases
- Bgee database
- BioGPS
- BioGRID Open Repository of CRISPR Screens (ORCS)
- Eukaryotic Promoter Database
- GlyGen glycoinformatics resource
- Guide to Pharmacology
- Human eFP Browser
- Ingenuity Pathways Analysis
- InnateDB
- InterMine
- Kyoto Encyclopedia of Genes and Genomes
- OMA Browser: Orthologous MAtrix
- OrthoDB catalog of orthologs
- PANTHER Classification System
- Pharmacogenomics Knowledge Base
- PhosphoSitePlus
- The Gene Wiki
- The Weizmann Institute of Science GeneCards and MalaCards databases
Research Materials
- Addgene Non-profit plasmid repository
- Bio-Techne
- Creative Biogene
- ExactAntigen/Labome
- GenScript latest version of gene cDNA ORF Clone
- GeneCopoeia Inc.
- GeneTex Inc
- Kazusa DNA Research Institute
- OriGene