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    CENPB centromere protein B [ Homo sapiens (human) ]

    Gene ID: 1059, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CENPBprovided by HGNC
    Official Full Name
    centromere protein Bprovided by HGNC
    Primary source
    HGNC:HGNC:1852
    See related
    Ensembl:ENSG00000125817 MIM:117140; AllianceGenome:HGNC:1852
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies. [provided by RefSeq, Jul 2008]
    Orthologs
    mouse all
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    Genomic context

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    See CENPB in Genome Data Viewer
    Location:
    20p13
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (3783851..3786740, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (3814791..3817680, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (3764498..3767387, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene adipose secreted signaling protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:3747545-3748309 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:3748437-3749023 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17482 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12627 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:3759113-3759730 Neighboring gene Sharpr-MPRA regulatory region 2213 Neighboring gene sperm flagellar 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:3766083-3766793 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:3766794-3767503 Neighboring gene cell division cycle 25B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:3775953-3776684 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12629 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12630 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:3777341-3777548 Neighboring gene Sharpr-MPRA regulatory region 3723 Neighboring gene Sharpr-MPRA regulatory region 8683 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:3782484-3783683 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:3787799-3788390 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:3788391-3788981 Neighboring gene long intergenic non-protein coding RNA 1730 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:3791796-3792995

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A human centromere protein, CENP-B, has a DNA binding domain containing four potential alpha helices at the NH2 terminus, which is separable from dimerizing activity. Yoda K, et al. J Cell Biol, 1992 Dec. PMID 1469042, Free PMC Article
    2. Anti-CENP-B antibodies are associated with prolonged survival in breast cancer. Atalay C, et al. Future Oncol, 2010 Mar. PMID 20222802
    3. HTLV-1 bZIP factor suppresses the centromere protein B (CENP-B)-mediated trimethylation of histone H3K9 through the abrogation of DNA-binding ability of CENP-B. Mukai R, et al. J Gen Virol, 2015 Jan. PMID 25281565
    4. Stable complex formation of CENP-B with the CENP-A nucleosome. Fujita R, et al. Nucleic Acids Res, 2015 May 26. PMID 25916850, Free PMC Article
    5. The nuclear autoantigen CENP-B displays cytokine-like activities toward vascular smooth muscle cells. Robitaille G, et al. Arthritis Rheum, 2007 Nov. PMID 17968937

    See all (103) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LINC01123 potentially correlates with radioresistance in glioma through the miR-151a/CENPB axis.
      Title: LINC01123 potentially correlates with radioresistance in glioma through the miR-151a/CENPB axis.
    2. CENP-B promotes the centromeric localization of ZFAT to control transcription of noncoding RNA.
      Title: CENP-B promotes the centromeric localization of ZFAT to control transcription of noncoding RNA.
    3. Centromeric transcription maintains centromeric cohesion in human cells.
      Title: Centromeric transcription maintains centromeric cohesion in human cells.
    4. Proteomics characterization of CENP-B epitope in Moroccan scleroderma patients with anti-centromere autoantibodies.
      Title: Proteomics characterization of CENP-B epitope in Moroccan scleroderma patients with anti-centromere autoantibodies.
    5. The Elusive Structure of Centro-Chromatin: Molecular Order or Dynamic Heterogenetity?
      Title: The Elusive Structure of Centro-Chromatin: Molecular Order or Dynamic Heterogenetity?
    6. A genetic memory initiates the epigenetic loop necessary to preserve centromere position.
      Title: A genetic memory initiates the epigenetic loop necessary to preserve centromere position.
    7. From evolution to function: Two sides of the same CENP-B coin?
      Title: From evolution to function: Two sides of the same CENP-B coin?
    8. Given that CENP-B is the only centromere protein that binds centromere-specific DNA elements, our study provides a new link between centromere DNA and unique epigenetic landscape of centromere chromatin
      Title: CENP-B protects centromere chromatin integrity by facilitating histone deposition via the H3.3-specific chaperone Daxx.
    9. Upon cross-linking, the entire CENPA/CENPB/CENPC/CENPT complex is nuclease-protected over an alpha-satellite dimer that comprises the fundamental unit of centromeric chromatin. We conclude that CENPA/CENPC and CENPT pathways for kinetochore assembly are physically integrated over young alpha-satellite dimers.
      Title: CENPT bridges adjacent CENPA nucleosomes on young human α-satellite dimers.
    10. Findings indicate that expression of the scleroderma autoantigens IFI-16 and CENPs, which are associated with severe vascular disease, is increased in vascular progenitors and mature endothelial cells. High level, lineage-enriched expression of autoantigens may explain the striking association between clinical phenotypes and the immune targeting of specific autoantigens.
      Title: Enrichment of Scleroderma Vascular Disease-Associated Autoantigens in Endothelial Lineage Cells.
    Submit: New GeneRIF Correction See all GeneRIFs (30)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables centromeric DNA binding IC
    Inferred by Curator
    more info
    		 PubMed 
    enables chromatin binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables satellite DNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables sequence-specific DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in condensed chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in pericentric heterochromatin IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    major centromere autoantigen B
    Names
    CENP-B
    centromere autoantigen B
    centromere protein B, 80kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001810.6 → NP_001801.1  major centromere autoantigen B

      See identical proteins and their annotated locations for NP_001801.1

      Status: REVIEWED

      Source sequence(s)
      AL109804, BC003649, BC053847
      Consensus CDS
      CCDS13064.1
      UniProtKB/Swiss-Prot
      P07199, Q96EI4
      Related
      ENSP00000369075.4, ENST00000379751.5
      Conserved Domains (4) summary
      smart00674
      Location:74 → 135
      CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
      pfam03184
      Location:222 → 384
      DDE_1; DDE superfamily endonuclease
      pfam04218
      Location:2 → 56
      CENP-B_N; CENP-B N-terminal DNA-binding domain
      pfam09026
      Location:539 → 598
      CENP-B_dimeris; Centromere protein B dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      3783851..3786740 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      3814791..3817680 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07199.2 GenPept UniProtKB/Swiss-Prot:P07199

    Gene LinkOut

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