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    PF3D7_0800200 erythrocyte membrane protein 1, PfEMP1 [ Plasmodium falciparum 3D7 ]

    Gene ID: 2655302, updated on 17-May-2024

    Summary

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    Gene symbol
    PF3D7_0800200
    Gene description
    erythrocyte membrane protein 1, PfEMP1
    Locus tag
    PF3D7_0800200
    See related
    PlasmoDB:PF3D7_0800200; VEuPathDB:PF3D7_0800200
    Gene type
    protein coding
    RNA name
    erythrocyte membrane protein 1, PfEMP1
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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    Genomic context

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    See PF3D7_0800200 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    2
    Sequence:
    Chromosome: 8; NC_004329.3 (29700..39033, complement)

    Chromosome 8 - NC_004329.3Genomic Context describing neighboring genes Neighboring gene erythrocyte membrane protein 1, PfEMP1 Neighboring gene erythrocyte membrane protein 1, PfEMP1 Neighboring gene rifin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_004329.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evidence of strain structure in Plasmodium falciparum var gene repertoires in children from Gabon, West Africa. Day KP, et al. Proc Natl Acad Sci U S A, 2017 May 16. PMID 28461509, Free PMC Article
    2. The cysteine-rich interdomain region from the highly variable plasmodium falciparum erythrocyte membrane protein-1 exhibits a conserved structure. Klein MM, et al. PLoS Pathog, 2008 Sep 5. PMID 18773118, Free PMC Article
    3. Plasmodium falciparum protein 'PfJ23' hosts distinct binding sites for major virulence factor 'PfEMP1' and Maurer's cleft marker 'PfSBP1'. Kaur J, et al. Pathog Dis, 2018 Dec 1. PMID 30576479
    4. A Plasmodium falciparum PHIST protein binds the virulence factor PfEMP1 and comigrates to knobs on the host cell surface. Oberli A, et al. FASEB J, 2014 Oct. PMID 24983468, Free PMC Article
    5. Antigenic variation in Plasmodium falciparum. Scherf A, et al. Annu Rev Microbiol, 2008. PMID 18785843

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest a probable role for PfJ23 (PF3D7_1001900) in export of PEXEL-negative proteins like PfSBP1 (PF3D7_0501300) and PfEMP1 (PF3D7_0800200), furthering our understanding of malaria biology.
      Title: Plasmodium falciparum protein 'PfJ23' hosts distinct binding sites for major virulence factor 'PfEMP1' and Maurer's cleft marker 'PfSBP1'.
    2. Deep sampling of the DBLalpha domain of var genes in the local population of Bakoumba, West Africa, showed extremely high diversity and a large parasite population with DBLalpha repertoires structured into nonrandom patterns of overlap.
      Title: Evidence of strain structure in Plasmodium falciparum var gene repertoires in children from Gabon, West Africa.
    3. describe the CD36-binding portion of a CIDR1alpha domain, MC179, as a bundle of three alpha-helices that are connected by a loop and three additional helices.
      Title: The cysteine-rich interdomain region from the highly variable plasmodium falciparum erythrocyte membrane protein-1 exhibits a conserved structure.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables cell adhesion molecule binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within adhesion of symbiont to microvasculature TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within antigenic variation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within cell-cell adhesion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within modulation by symbiont of host erythrocyte aggregation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in host cell plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in infected host cell surface knob TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    erythrocyte membrane protein 1, PfEMP1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004329.3 Reference assembly

      Range
      29700..39033 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001349477.1 → XP_001349513.1  erythrocyte membrane protein 1, PfEMP1 [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001349513.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S9VP34, Q8IAK2, W7K6X4
      Conserved Domains (3) summary
      PTZ00176
      Location:1649 → 2858
      PTZ00176; erythrocyte membrane protein 1 (PfEMP1); Provisional
      pfam03011
      Location:566 → 706
      PFEMP; PFEMP DBL domain
      pfam18562
      Location:499 → 550
      CIDR1_gamma; Cysteine-Rich Interdomain Region 1 gamma
    Nucleotide Protein
    Heading Accession and Version

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