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    mmi1 YTH family RNA-binding protein Mmi1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539540, updated on 22-Jun-2024

    Summary

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    Gene symbol
    mmi1
    Gene description
    YTH family RNA-binding protein Mmi1
    Locus tag
    SPOM_SPCC736.12C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Old locus tag
    SPCC736.12c
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    Genomic context

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    See mmi1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003421.2 (337088..340112, complement)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene argonaute Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene dehydrogenase Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A low-complexity region in the YTH domain protein Mmi1 enhances RNA binding. Stowell JAW, et al. J Biol Chem, 2018 Jun 15. PMID 29695507, Free PMC Article
    2. Structural insights into the specific recognition of DSR by the YTH domain containing protein Mmi1. Wu B, et al. Biochem Biophys Res Commun, 2017 Sep 16. PMID 28735863
    3. A novel RNA-binding mode of the YTH domain reveals the mechanism for recognition of determinant of selective removal by Mmi1. Wang C, et al. Nucleic Acids Res, 2016 Jan 29. PMID 26673708, Free PMC Article
    4. A scaffold lncRNA shapes the mitosis to meiosis switch. Andric V, et al. Nat Commun, 2021 Feb 3. PMID 33536434, Free PMC Article
    5. Inactivation of fission yeast Erh1 de-represses pho1 expression: evidence that Erh1 is a negative regulator of prt lncRNA termination. Schwer B, et al. RNA, 2020 Oct. PMID 32546512, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interaction of S. pombe Mmi1 with the nuclear exosome is mediated by a complex termed MTREC (Mtl1-Red1 core) or NURS (nuclear RNA silencing) that is composed of a conserved zinc-finger protein, Red1, and an RNA helicase, Mtl1. Physical interaction between Mmi1 and the nuclear exosome depends on Red1. Study findings shed light on the target recognition mechanisms of post-transcriptional regulation.
      Title: Meiotic gene silencing complex MTREC/NURS recruits the nuclear exosome to YTH-RNA-binding protein Mmi1.
    2. The authors propose that nuclear foci formed by Mmi1 are not only the site of RNA degradation, but also of sequestration of meiotic transcripts from the translation machinery.
      Title: YTH-RNA-binding protein prevents deleterious expression of meiotic proteins by tethering their mRNAs to nuclear foci.
    3. Study suggests that at meiotic initiation, Mei2 may sequester rep2 mRNA to help allow pre-meiotic S, and then may bind both meiRNA and mmi1 mRNA to inactivate Mmi1 at two levels, the protein level and also the mRNA level, allowing meiosis.
      Title: mmi1 and rep2 mRNAs are novel RNA targets of the Mei2 RNA-binding protein during early meiosis in Schizosaccharomyces pombe.
    4. Study discover that an important function of Mmi1 in promoting non-canonical transcription termination at meiotic genes, and in preventing lncRNAs from invading and repressing adjacent genes, is not dependent upon its association with Erh1.
      Title: A conserved dimer interface connects ERH and YTH family proteins to promote gene silencing.
    5. This study reports that an N-terminal extension in mmi1 that is proximal to the YTH domain enhances RNA binding. Using X-ray crystallography, NMR, and biophysical methods, the study shows that this low-complexity region in mmi1 becomes more ordered upon RNA binding.
      Title: A low-complexity region in the YTH domain protein Mmi1 enhances RNA binding.
    6. The authors propose that Mmi1 recruits the Ccr4-Not complex to counteract its own inhibitor Mei2, thereby locking the system in a stable state that ensures the repression of the meiotic program by Mmi1.
      Title: Ubiquitination-dependent control of sexual differentiation in fission yeast.
    7. Mmi1 can recognize and bind a class of meiosis-specific transcripts expressed inappropriately in mitotic cells; structural insights into the specific recognition of these mRNAs by the YTH domain containing protein Mmi1 have been presented.
      Title: Structural insights into the specific recognition of DSR by the YTH domain containing protein Mmi1.
    8. report the 1.75 A crystal structure of the Mmi1 YTH domain and provide evidence that Mmi1 recognizes DSR RNA via a binding mode distinct from that of structurally homologous YTH proteins that recognize m(6)A-modified RNA
      Title: Transcription of lncRNA prt, clustered prt RNA sites for Mmi1 binding, and RNA polymerase II CTD phospho-sites govern the repression of pho1 gene expression under phosphate-replete conditions in fission yeast.
    9. Erh1 and the RNA-binding protein Mmi1 form a stoichiometric complex, called the Erh1-Mmi1 complex (EMC), to promote meiotic mRNA decay and facultative heterochromatin assembly.
      Title: Enhancer of Rudimentary Cooperates with Conserved RNA-Processing Factors to Promote Meiotic mRNA Decay and Facultative Heterochromatin Assembly.
    10. Mmi1 YTH domain selectively recognizes the determinant of selective removal RNA motif.
      Title: A novel RNA-binding mode of the YTH domain reveals the mechanism for recognition of determinant of selective removal by Mmi1.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables CCR4-NOT complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N6-methyladenosine-containing RNA reader activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lncRNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pre-mRNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables pre-mRNA intronic binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-RNA adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein-RNA adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lncRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA destabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear RNA surveillance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear lncRNA surveillance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear mRNA surveillance of mRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear mRNA surveillance of spliceosomal pre-mRNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear polyadenylation-dependent CUT catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of siRNA-independent facultative heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulatory ncRNA 3'-end processing EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in regulatory ncRNA-mediated gene silencing EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in siRNA-independent facultative heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Mei2 nuclear dot complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of heterochromatin island IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear exosome focus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    YTH family RNA-binding protein Mmi1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      337088..340112 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022776.4 → NP_587783.2  YTH family RNA-binding protein Mmi1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_587783.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74958
      Conserved Domains (1) summary
      pfam04146
      Location:350 → 477
      YTH; YT521-B-like domain
    Nucleotide Protein
    Heading Accession and Version

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