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    CEK1 mitogen-activated serine/threonine-protein kinase [ Candida albicans SC5314 ]

    Gene ID: 3642789, updated on 30-Nov-2023

    Summary

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    Gene symbol
    CEK1
    Gene description
    mitogen-activated serine/threonine-protein kinase
    Locus tag
    CAALFM_C406480CA
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Candida albicans SC5314 (strain: SC5314, nat-host: Homo sapiens, culture-collection: ATCC:MYA-2876)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida
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    Genomic context

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    See CEK1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    1
    Sequence:
    Chromosome: 4; NC_032092.1 (1437628..1438893, complement)

    Chromosome 4 - NC_032092.1Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene DNA primase subunit Neighboring gene chromatin-remodeling protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_032092.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic code ambiguity modulates the activity of a C. albicans MAP kinase linked to cell wall remodeling. Fraga JS, et al. Biochim Biophys Acta Proteins Proteom, 2019 Jun. PMID 30797104
    2. Generating genomic platforms to study Candida albicans pathogenesis. Legrand M, et al. Nucleic Acids Res, 2018 Aug 21. PMID 29982705, Free PMC Article
    3. The Cek1‑mediated MAP kinase pathway regulates exposure of α‑1,2 and β‑1,2‑mannosides in the cell wall of Candida albicans modulating immune recognition. Román E, et al. Virulence, 2016 Jul 3. PMID 27191378, Free PMC Article
    4. Secreted aspartic protease cleavage of Candida albicans Msb2 activates Cek1 MAPK signaling affecting biofilm formation and oropharyngeal candidiasis. Puri S, et al. PLoS One, 2012. PMID 23139737, Free PMC Article
    5. Evolutionary reshaping of fungal mating pathway scaffold proteins. Côte P, et al. mBio, 2011 Jan 11. PMID 21249169, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study shows that insertion of a leucine at the CUG-encoded position decreases the stability of Cek1, without major structural alterations. In contrast, incorporation of a serine residue induces the autophosphorylation of the conserved tyrosine residue of the Cek1 (231)TEY(233) motif increasing its intrinsic activity. These data show that CUG ambiguity modulates the activity of cek1 linked to virulence and morphogenesis.
      Title: Genetic code ambiguity modulates the activity of a C. albicans MAP kinase linked to cell wall remodeling.
    2. While some level of mating can occur in the presence of a single kinase, the Cek1 kinase is most important for mating, while the Cek2 kinase is involved in adaptation to signaling. While both kinases appear to be themselves regulated by dephosphorylation through the action of the Cpp1 phosphatase, this process appears important for mating only in the case of Cek1.
      Title: MAP Kinase Regulation of the Candida albicans Pheromone Pathway.
    3. independent hyperactivation of the MAP kinase kinase kinase Ste11 in wild-type cells leads to Cek1 activation and increased beta (1,3)-glucan exposure. Thus, upregulation of the Cek1 MAPK pathway causes unmasking, and may be responsible for unmasking in cho1Delta/Delta.
      Title: Exposure of Candida albicans β (1,3)-glucan is promoted by activation of the Cek1 pathway.
    4. The results suggest that the MPK-1/ERK regulatory network, including FBF-1, FBF-2, and LIP-1, controls the number of sperm by regulating the timing of the sperm-oocyte switch in C. elegans.
      Title: MPK-1/ERK regulatory network controls the number of sperm by regulating timing of sperm-oocyte switch in C. elegans germline.
    5. data support a role for the Cek1mediated pathway in fungal cell wall maintenance, virulence and antifungal discovery
      Title: The Cek1‑mediated MAP kinase pathway regulates exposure of α‑1,2 and β‑1,2‑mannosides in the cell wall of Candida albicans modulating immune recognition.
    6. Cek2 has a cryptic role in cell-wall biogenesis and its role is not entirely redundant to Cek1.
      Title: Complementary roles of the Cek1 and Cek2 MAP kinases in Candida albicans cell-wall biogenesis.
    7. knockdown of SUV420H1 reduced phosphorylated ERK1 and total ERK1 proteins, and interestingly suppressed ERK1 at the transcriptional level
      Title: SUV420H1 enhances the phosphorylation and transcription of ERK1 in cancer cells.
    8. Secreted aspartic protease-mediated proteolytic cleavage of Msb2 is required for activation of the Cek1 mitogen activated protein kinase pathway in response to environmental cues.
      Title: Secreted aspartic protease cleavage of Candida albicans Msb2 activates Cek1 MAPK signaling affecting biofilm formation and oropharyngeal candidiasis.
    9. The authors propose that a Msb2, Cek1 and Ace2 signalling pathway addresses PMT genes as downstream targets and that different modes of regulation have evolved for PMT1 and PMT2/PMT4 genes.
      Title: Damage to the glycoshield activates PMT-directed O-mannosylation via the Msb2-Cek1 pathway in Candida albicans.
    10. Dfi1 function promotes matrix-dependent activation of Cek1 kinase during growth.
      Title: A Candida albicans cell wall-linked protein promotes invasive filamentation into semi-solid medium.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitogen-activated serine/threonine-protein kinase
    XP_715542.2
    • ERK-family protein kinase; required for wild-type yeast-hypha switch, mating efficiency, virulence in mice; Cst20-Hst7-Cek1-Cph1 MAPK pathway regulates mating, and invasive hyphal growth under some conditions; Spider biofilm induced

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_032092.1 Reference assembly

      Range
      1437628..1438893 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_710449.2 → XP_715542.2  mitogen-activated serine/threonine-protein kinase [Candida albicans SC5314]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      A0A1D8PMK1, C4YGK0, O13435, P28869, P87079, P87080, P87081, P87082, P87083, P87084, P87085, P87086, P87322, Q5A1D3, Q6LC13
      Conserved Domains (1) summary
      cd07849
      Location:64 → 419
      STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
    Nucleotide Protein
    Heading Accession and Version

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