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    proQ activator of proP [ Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 ]

    Gene ID: 1253365, updated on 4-Feb-2024

    Summary

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    Gene symbol
    proQ
    Gene description
    activator of proP
    Locus tag
    STM1846
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 (strain: LT2, serovar: Typhimurium, sub-species: enterica, culture-collection: ATCC:700720, culture-collection: SGSC:1412, type-material: type strain of Salmonella enterica)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Salmonella
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    Genomic context

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    Sequence:
    NC_003197.2 (1943199..1943896, complement)

    NC_003197.2Genomic Context describing neighboring genes Neighboring gene heat shock protein Neighboring gene carboxy-terminal protease for penicillin-binding protein 3 Neighboring gene putative GAF domain-containing protein Neighboring gene putative inner membrane protein Neighboring gene putative inner membrane protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003197.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Saturation mutagenesis charts the functional landscape of Salmonella ProQ and reveals a gene regulatory function of its C-terminal domain. Rizvanovic A, et al. Nucleic Acids Res, 2021 Sep 27. PMID 34450657, Free PMC Article
    2. The Major RNA-Binding Protein ProQ Impacts Virulence Gene Expression in Salmonella enterica Serovar Typhimurium. Westermann AJ, et al. mBio, 2019 Jan 2. PMID 30602583, Free PMC Article
    3. Molecular mechanism of mRNA repression in trans by a ProQ-dependent small RNA. Smirnov A, et al. EMBO J, 2017 Apr 13. PMID 28336682, Free PMC Article
    4. Global Maps of ProQ Binding In Vivo Reveal Target Recognition via RNA Structure and Stability Control at mRNA 3' Ends. Holmqvist E, et al. Mol Cell, 2018 Jun 7. PMID 29804828
    5. Complete genome sequence of Salmonella enterica serovar Typhimurium LT2. McClelland M, et al. Nature, 2001 Oct 25. PMID 11677609

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Saturation mutagenesis charts the functional landscape of Salmonella ProQ and reveals a gene regulatory function of its C-terminal domain.
      Title: Saturation mutagenesis charts the functional landscape of Salmonella ProQ and reveals a gene regulatory function of its C-terminal domain.
    2. Here, using a Dual RNA-seq approach to profile ProQ-dependent gene expression changes as Salmonella infects human cells, the authors reveal dysregulation of bacterial motility, chemotaxis, and virulence genes which is accompanied by altered MAPK (mitogen-activated protein kinase) signaling in the host.
      Title: The Major RNA-Binding Protein ProQ Impacts Virulence Gene Expression in Salmonella enterica Serovar Typhimurium.
    3. ProQ targets sRNAs and mRNA 30 UTRs primarily through a structural code and to stabilize some mRNAs by counteracting 30 exoribonuclease activity.
      Title: Global Maps of ProQ Binding In Vivo Reveal Target Recognition via RNA Structure and Stability Control at mRNA 3' Ends.
    4. RaiZ forms an RNA duplex with the ribosome-binding site of hupA mRNA, facilitated by ProQ, to prevent 30S ribosome loading and protein synthesis of HU-alpha.
      Title: Molecular mechanism of mRNA repression in trans by a ProQ-dependent small RNA.
    Submit: New GeneRIF Correction

    General gene information

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    regulatory

    • Loc: c1943896-1943891 regulatory_class = ribosome_binding_site

    General protein information

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    Preferred Names
    activator of proP
    NP_460802.1
    • similar to E. coli orf, hypothetical protein (AAC74901.1); Blastp hit to AAC74901.1 (39 aa), 94% identity in aa 1 - 39

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003197.2 Reference assembly

      Range
      1943199..1943896 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_460802.1 activator of proP [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]

      See identical proteins and their annotated locations for NP_460802.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A447NS79, A0A5T8J4H7, A0A5U4CY67, A0A5U5AQL9, A0A5X8ARN5, A0A5X9ET83, A0A5Z4A0P4, A0A701S3W6, A0A704F1L2, A0A725MRW7, A0A739TL38, A0A745H0U1, A0A749BV87, A0A754T4X4, A0A759SC67
      Conserved Domains (1) summary
      PRK04950
      Location:1 → 228
      PRK04950; ProP expression regulator; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P60317.1

    Gene LinkOut

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    Other Literature Sources
    Molecular Biology Databases
    Research Materials