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    POLY polyprotein [ Yellow fever virus ]

    Gene ID: 1502173, updated on 18-Aug-2023

    Summary

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    Gene symbol
    POLY
    Gene description
    polyprotein
    Locus tag
    YFVgp1
    Gene type
    protein coding
    RNA name
    PP mRNA
    RefSeq status
    REVIEWED
    Organism
    Yellow fever virus (strain: 17D vaccine strain)
    Lineage
    Viruses; Riboviria; Flaviviridae; Flavivirus
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    Genomic context

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    Sequence:
    NC_002031.1 (1..10862)

    NC_002031.1Genomic Context describing neighboring genes

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002031.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a dominant endoplasmic reticulum-retention signal in yellow fever virus pre-membrane protein. Ciczora Y, et al. J Gen Virol, 2010 Feb. PMID 19846669
    2. Nucleotide sequence of yellow fever virus: implications for flavivirus gene expression and evolution. Rice CM, et al. Science, 1985 Aug 23. PMID 4023707
    3. NS2B-3 proteinase-mediated processing in the yellow fever virus structural region: in vitro and in vivo studies. Amberg SM, et al. J Virol, 1994 Jun. PMID 8189517, Free PMC Article
    4. RNA-stimulated NTPase activity associated with yellow fever virus NS3 protein expressed in bacteria. Warrener P, et al. J Virol, 1993 Feb. PMID 8380474, Free PMC Article
    5. Mutagenesis of the NS2B-NS3-mediated cleavage site in the flavivirus capsid protein demonstrates a requirement for coordinated processing. Amberg SM, et al. J Virol, 1999 Oct. PMID 10482557, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural characterization and polymorphism analysis of the NS2B-NS3 protease from the 2017 Brazilian circulating strain of Yellow Fever virus.
      Title: Structural characterization and polymorphism analysis of the NS2B-NS3 protease from the 2017 Brazilian circulating strain of Yellow Fever virus.
    2. The structure of the full-length NS5 protein, a key enzyme for the replication of flaviviruses that contains both a methyltransferase domain and an RNA dependent RNA polymerase domain, at 3.1 A resolution.
      Title: Structure of the yellow fever NS5 protein reveals conserved drug targets shared among flaviviruses.
    3. Host-Specific NS5 Ubiquitination Determines Yellow Fever Virus Tropism.
      Title: Host-Specific NS5 Ubiquitination Determines Yellow Fever Virus Tropism.
    4. adaptive genetic diversification has occurred on viral nonstructural protein 5 in African and South American yellow fever virus populations
      Title: Adaptive Diversification Between Yellow Fever Virus West African and South American Lineages: A Genome-Wide Study.
    5. This suggests that DNAJC14's folding activity normally modulates yellow fever virus NS3/4A/2K cleavage events to liberate appropriate levels of NS3 and NS4A and promote replication complex formation.
      Title: Chaperone-Assisted Protein Folding Is Critical for Yellow Fever Virus NS3/4A Cleavage and Replication.
    6. These data support a complex interplay between yellow fever virus NS2A and NS3 in virion assembly and identify a basic cluster in the NS2A N terminus to be critical in this process.[NS2A, NS3]
      Title: A basic cluster in the N terminus of yellow fever virus NS2A contributes to infectious particle production.
    7. Binding of Yellow fever virus NS5 to the IFN-activated transcription factor STAT2 only in cells that have been stimulated with IFN-beta.
      Title: The interferon signaling antagonist function of yellow fever virus NS5 protein is activated by type I interferon.
    8. While the increase of the positive charge in the envelope protein domain III may reduce the virulence of YFV in mice, this mutation favored the establishment of the viral infection in Aedes aegypti.
      Title: Mutagenesis analysis of T380R mutation in the envelope protein of yellow fever virus.
    9. These results indicate an interaction of human eIF3L with yellow fever virus NS5 and that eIF3L overexpression facilitates translation, which has potential implications for virus replication.
      Title: The eukaryotic translation initiation factor 3 subunit L protein interacts with Flavivirus NS5 and may modulate yellow fever virus replication.
    10. study shows that the yellow fever virus (YFV) NS5 protein is able to interact with U1A, a protein involved in splicing and polyadenylation; a region between amino acids 368 and 448 was identified as the site of interaction of the NS5 protein with U1A
      Title: The small nuclear ribonucleoprotein U1A interacts with NS5 from yellow fever virus.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

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    Preferred Names
    polyprotein
    Names
    core protein C
    anchored core protein C
    M protein precursor
    matrix protein M
    envelope protein
    non-structural protein NS1
    non-structural protein NS2a
    non-structural protein NS2b
    non-structural protein NS3
    non-structural protein NS4a
    2K protein
    non-structural protein NS4b
    RNA-dependent RNA polymerase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002031.1 Reference assembly

      Range
      1..10862
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_041726.1 polyprotein precursor [Yellow fever virus]

      See identical proteins and their annotated locations for NP_041726.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O42028, O91857, P03314, P19901, Q102J3, Q45RQ2, Q89275, Q89276, Q9W878, Q9YWN0, Q9YWN1, Q9YWN2
      UniProtKB/TrEMBL
      A0A2R4G6T0
      Conserved Domains (20) summary
      pfam01003
      Location:5 → 101
      Flavi_capsid; Flavivirus capsid protein C
      pfam01003
      Location:5 → 119
      Flavi_capsid; Flavivirus capsid protein C
      pfam01004
      Location:91 → 164
      Flavi_M; Flavivirus envelope glycoprotein M
      pfam01570
      Location:5 → 82
      Flavi_propep; Flavivirus polyprotein propeptide
      pfam01004
      Location:2 → 75
      Flavi_M; Flavivirus envelope glycoprotein M
      TIGR04240
      Location:397 → 493
      flavi_E_stem; flavivirus envelope glycoprotein E, stem/anchor domain
      pfam00869
      Location:2 → 294
      Flavi_glycoprot; Flavivirus glycoprotein, central and dimerization domains
      pfam02832
      Location:296 → 391
      Flavi_glycop_C; Flavivirus glycoprotein, immunoglobulin-like domain
      pfam00948
      Location:2 → 352
      Flavi_NS1; Flavivirus non-structural Protein NS1
      pfam01005
      Location:9 → 194
      Flavi_NS2A; Flavivirus non-structural protein NS2A
      pfam01002
      Location:4 → 130
      Flavi_NS2B; Flavivirus non-structural protein NS2B
      smart00487
      Location:184 → 330
      DEXDc; DEAD-like helicases superfamily
      cd00079
      Location:366 → 478
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00949
      Location:21 → 170
      Peptidase_S7; Peptidase S7, Flavivirus NS3 serine protease
      pfam07652
      Location:190 → 335
      Flavi_DEAD; Flavivirus DEAD domain
      pfam01350
      Location:4 → 126
      Flavi_NS4A; Flavivirus non-structural protein NS4A
      pfam01350
      Location:1 → 21
      Flavi_NS4A; Flavivirus non-structural protein NS4A
      pfam01349
      Location:1 → 244
      Flavi_NS4B; Flavivirus non-structural protein NS4B
      pfam00972
      Location:252 → 897
      Flavi_NS5; Flavivirus RNA-directed RNA polymerase
      cd20761
      Location:8 → 237
      capping_2-OMTase_Flaviviridae; Cap-0 specific (nucleoside-2'-O-)-methyltransferase of flaviviridae
    Nucleotide Protein
    Heading Accession and Version

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