U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    SH3D21 SH3 domain containing 21 [ Homo sapiens (human) ]

    Gene ID: 79729, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    SH3D21provided by HGNC
    Official Full Name
    SH3 domain containing 21provided by HGNC
    Primary source
    HGNC:HGNC:26236
    See related
    Ensembl:ENSG00000214193 AllianceGenome:HGNC:26236
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C1orf113
    Summary
    Predicted to be involved in actin filament organization and cell migration. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in small intestine (RPKM 7.0), skin (RPKM 5.6) and 23 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See SH3D21 in Genome Data Viewer
    Location:
    1p34.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (36306368..36330236)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (36168306..36192094)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (36771969..36786948)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 131, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr1:36680691-36680811 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 747 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:36689434-36689961 Neighboring gene thyroid hormone receptor associated protein 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:36689962-36690490 Neighboring gene Sharpr-MPRA regulatory regions 10257 and 14041 Neighboring gene ubiquitin conjugating enzyme E2 V2 pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 659 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:36726300-36726456 Neighboring gene Sharpr-MPRA regulatory region 2392 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 660 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36772217-36773017 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36786744-36787628 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36788515-36789399 Neighboring gene eva-1 homolog B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 751 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:36823274-36823774 Neighboring gene serine/threonine kinase 40 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36834695-36835363 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36835364-36836031 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36837681-36838244 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36838245-36838808 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:36839045-36840244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:36844393-36844892 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 666 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 667 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 668 Neighboring gene uncharacterized LOC124904012 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:36851839-36853038

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A genome-scale CRISPR/Cas9 knockout screening reveals SH3D21 as a sensitizer for gemcitabine. Masoudi M, et al. Sci Rep, 2019 Dec 16. PMID 31844142, Free PMC Article
    2. Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra. Yu LR, et al. J Proteome Res, 2007 Nov. PMID 17924679
    3. SUMO-specific protease 2 (SENP2) suppresses keratinocyte migration by targeting NDR1 for de-SUMOylation. Xiao N, et al. FASEB J, 2019 Jan. PMID 29969578
    4. POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1. Wang B, et al. EBioMedicine, 2019 Mar. PMID 30745168, Free PMC Article
    5. Proteome-scale mapping of binding sites in the unstructured regions of the human proteome. Benz C, et al. Mol Syst Biol, 2022 Jan. PMID 35044719, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • FLJ22938

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    SH3 domain-containing protein 21
    Names
    SH3 domain-containing protein C1orf113

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162530.2 → NP_001156002.1  SH3 domain-containing protein 21 isoform 1

      See identical proteins and their annotated locations for NP_001156002.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL591845
      UniProtKB/Swiss-Prot
      A4FU49, B4DLI6, D3DPS6, J3KQM5, Q5VTK7, Q86XZ6, Q8N445, Q96DN4, Q9H5W5
      Related
      ENSP00000403476.2, ENST00000453908.8
      Conserved Domains (3) summary
      cd11874
      Location:87 → 139
      SH3_CD2AP-like_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein and similar proteins
      cd12142
      Location:185 → 239
      SH3_D21-like; Src Homology 3 domain of SH3 domain-containing protein 21 (SH3D21) and similar proteins
      cl17036
      Location:2 → 55
      SH3; Src Homology 3 domain superfamily

    2. NM_024676.5 → NP_078952.4  SH3 domain-containing protein 21 isoform 2

      See identical proteins and their annotated locations for NP_078952.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AL591845
      Consensus CDS
      CCDS30674.2
      UniProtKB/Swiss-Prot
      A4FU49, B4DLI6, D3DPS6, J3KQM5, Q5VTK7, Q86XZ6, Q8N445, Q96DN4, Q9H5W5
      Related
      ENSP00000421294.1, ENST00000505871.7
      Conserved Domains (2) summary
      cd12142
      Location:74 → 128
      SH3_D21-like; Src Homology 3 domain of SH3 domain-containing protein 21 (SH3D21) and similar proteins
      cl17036
      Location:1 → 28
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      36306368..36330236
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017002340.2 → XP_016857829.1  SH3 domain-containing protein 21 isoform X1

    2. XM_017002341.2 → XP_016857830.1  SH3 domain-containing protein 21 isoform X2

    3. XM_017002344.2 → XP_016857833.1  SH3 domain-containing protein 21 isoform X4

      Conserved Domains (4) summary
      cd11874
      Location:87 → 139
      SH3_CD2AP-like_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein and similar proteins
      cd12142
      Location:185 → 239
      SH3_D21-like; Src Homology 3 domain of SH3 domain-containing protein 21 (SH3D21) and similar proteins
      PHA03247
      Location:239 → 675
      PHA03247; large tegument protein UL36; Provisional
      cl17036
      Location:2 → 55
      SH3; Src Homology 3 domain superfamily

    4. XM_017002345.2 → XP_016857834.1  SH3 domain-containing protein 21 isoform X5

    5. XM_017002342.3 → XP_016857831.1  SH3 domain-containing protein 21 isoform X3

      Conserved Domains (3) summary
      cd11874
      Location:87 → 139
      SH3_CD2AP-like_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein and similar proteins
      cd12142
      Location:185 → 239
      SH3_D21-like; Src Homology 3 domain of SH3 domain-containing protein 21 (SH3D21) and similar proteins
      cl17036
      Location:2 → 55
      SH3; Src Homology 3 domain superfamily

    6. XM_047430650.1 → XP_047286606.1  SH3 domain-containing protein 21 isoform X7

    7. XM_047430644.1 → XP_047286600.1  SH3 domain-containing protein 21 isoform X6

    8. XM_047430651.1 → XP_047286607.1  SH3 domain-containing protein 21 isoform X8

    9. XM_047430653.1 → XP_047286609.1  SH3 domain-containing protein 21 isoform X9

    10. XM_047430654.1 → XP_047286610.1  SH3 domain-containing protein 21 isoform X10

    RNA

    1. XR_007063699.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      36168306..36192094
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338756.1 → XP_054194731.1  SH3 domain-containing protein 21 isoform X11

    2. XM_054338753.1 → XP_054194728.1  SH3 domain-containing protein 21 isoform X1

    3. XM_054338754.1 → XP_054194729.1  SH3 domain-containing protein 21 isoform X2

    4. XM_054338755.1 → XP_054194730.1  SH3 domain-containing protein 21 isoform X3

    5. XM_054338757.1 → XP_054194732.1  SH3 domain-containing protein 21 isoform X5

    6. XM_054338759.1 → XP_054194734.1  SH3 domain-containing protein 21 isoform X7

    7. XM_054338758.1 → XP_054194733.1  SH3 domain-containing protein 21 isoform X6

    8. XM_054338760.1 → XP_054194735.1  SH3 domain-containing protein 21 isoform X8

    9. XM_054338761.1 → XP_054194736.1  SH3 domain-containing protein 21 isoform X9

    10. XM_054338762.1 → XP_054194737.1  SH3 domain-containing protein 21 isoform X10

    RNA

    1. XR_008486164.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4FU49.2 GenPept UniProtKB/Swiss-Prot:A4FU49

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools