nrp1.L neuropilin 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: nrp1.L
Official Full Name: neuropilin 1 L homeolog
Primary source: Xenbase:XB-GENE-865400
Locus tag: XELAEV_18032864mg
See related: EnsemblRapid:ENSXLAG00005027874
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: nrp; np-1; nrp1; npn-1; nrp-1; pNPG152; neuropilin
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Genomic context

Location:: chromosome: 6S

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	6S	NC_054382.1 (16180382..16293822)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	6S	NC_030735.1 (15816199..15929634)

Chromosome 6S - NC_054382.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hermes negatively controls the translation of the guidance cue receptor Neuropilin-1 in retinal ganglion cells
Title: Hermes Regulates Axon Sorting in the Optic Tract by Post-Trancriptional Regulation of Neuropilin 1.
Neuropilin-1 and its co-receptor plexinA1 are necessary to bias the extension of the dendrites of retinal ganglion cells to the apical side of the cell, and ectopically expressed class III semaphorins (Sema3s) disrupt this process.
Title: Neuropilin-1 biases dendrite polarization in the retina.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables semaphorin receptor activity	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor binding	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axon guidance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neural crest cell migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of endothelial cell migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of filopodium assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of plasma membrane bounded cell projection organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of vascular endothelial growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to wounding	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sprouting angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vascular endothelial growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vasculogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neuropilin-1

Names: A5 antigen; A5-protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087911.1 → NP_001081380.1 neuropilin-1 precursor

See identical proteins and their annotated locations for NP_001081380.1

Status: PROVISIONAL

Source sequence(s)

BC084198

UniProtKB/Swiss-Prot

P28824

UniProtKB/TrEMBL

Q5XH75

Related

ENSXLAP00005083368.1, ENSXLAT00005085006.1

Conserved Domains (7) summary

cd06263
Location:651 → 804

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

pfam11980
Location:841 → 917

DUF3481; Domain of unknown function (DUF3481)

smart00137
Location:646 → 805

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00231
Location:275 → 424

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:147 → 264

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:277 → 423

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

pfam00431
Location:27 → 138

CUB; CUB domain