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    POLY polyprotein [ Guereza hepacivirus ]

    Gene ID: 30313404, updated on 18-Aug-2023

    Summary

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    Gene symbol
    POLY
    Gene description
    polyprotein
    Locus tag
    BRL49_gp1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Guereza hepacivirus (isolate: GHV-2 BWC04, nat-host: black-and-white colobus)
    Lineage
    Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes; Amarillovirales; Flaviviridae; Hepacivirus
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    Genomic context

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    Sequence:
    NC_031950.1 (271..10272)

    NC_031950.1Genomic Context describing neighboring genes

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_031950.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel hepacivirus with an unusually long and intrinsically disordered NS5A protein in a wild Old World primate. Lauck M, et al. J Virol, 2013 Aug. PMID 23740998, Free PMC Article
    2. Natural reservoirs for homologs of hepatitis C virus. Pfaender S, et al. Emerg Microbes Infect, 2014 Mar. PMID 26038514, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General protein information

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    Preferred Names
    polyprotein
    Names
    core protein C
    envelope protein E1
    envelope protein E2
    protein p7
    nonstructural protein NS2
    protease-helicase NS3
    nonstructural protein NS4A
    nonstructural protein NS4B
    nonstructural protein NS5A
    RNA-dependent RNA polymerase NS5B
    YP_009325369.1
    • Cleavage sites were added by NCBI staff based on PMID: 26038514 and homology to other hepaciviruses

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_031950.1 Reference assembly

      Range
      271..10272
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_009325369.1 polyprotein [Guereza hepacivirus]

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      S5DS99, S5DV86
      Conserved Domains (11) summary
      pfam01001
      Location:1639 → 1809
      HCV_NS4b; Hepatitis C virus non-structural protein NS4b
      pfam01539
      Location:207 → 383
      HCV_env; Hepatitis C virus envelope glycoprotein E1
      pfam01560
      Location:453 → 632
      HCV_NS1; Hepatitis C virus non-structural protein E2/NS1
      PHA03247
      Location:2225 → 2531
      PHA03247; large tegument protein UL36; Provisional
      COG3827
      Location:2625 → 2780
      PopZ; Cell pole-organizing protein PopZ [Cell cycle control, cell division, chromosome partitioning]
      pfam01542
      Location:109 → 159
      HCV_core; Hepatitis C virus core protein
      cl38915
      Location:1264 → 1385
      DEAD-like_helicase_C; C-terminal helicase domain of the DEAD-like helicases
      pfam01538
      Location:836 → 907
      HCV_NS2; Hepatitis C virus non-structural protein NS2
      pfam02907
      Location:957 → 1097
      Peptidase_S29; Hepatitis C virus NS3 protease
      cl02808
      Location:2762 → 3248
      RT_like; Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons, retroviruses, group ...
      cl28899
      Location:1127 → 1268
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    2. YP_009684354.1 core protein C

      Conserved Domains (1) summary
      pfam01542
      Location:109 → 159
      HCV_core; Hepatitis C virus core protein

    3. YP_009684355.1 envelope protein E1

      Conserved Domains (1) summary
      pfam01539
      Location:26 → 202
      HCV_env; Hepatitis C virus envelope glycoprotein E1

    4. YP_009684356.1 envelope protein E2

      Conserved Domains (1) summary
      pfam01560
      Location:86 → 240
      HCV_NS1; Hepatitis C virus non-structural protein E2/NS1

    5. YP_009684357.1 protein p7

    6. YP_009684358.1 nonstructural protein NS2

      Conserved Domains (1) summary
      pfam01538
      Location:117 → 188
      HCV_NS2; Hepatitis C virus non-structural protein NS2

    7. YP_009684359.1 protease-helicase NS3

      Conserved Domains (3) summary
      cl38915
      Location:337 → 458
      DEAD-like_helicase_C; C-terminal helicase domain of the DEAD-like helicases
      pfam02907
      Location:30 → 170
      Peptidase_S29; Hepatitis C virus NS3 protease
      cl28899
      Location:200 → 341
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    8. YP_009684360.1 nonstructural protein NS4A

    9. YP_009684361.1 nonstructural protein NS4B

      Conserved Domains (1) summary
      pfam01001
      Location:27 → 197
      HCV_NS4b; Hepatitis C virus non-structural protein NS4b

    10. YP_009684362.1 nonstructural protein NS5A

      Conserved Domains (2) summary
      PHA03247
      Location:365 → 671
      PHA03247; large tegument protein UL36; Provisional
      pfam08300
      Location:39 → 65
      HCV_NS5a_1a; Hepatitis C virus non-structural 5a zinc finger domain

    11. YP_009684363.1 RNA-dependent RNA polymerase NS5B

      Conserved Domains (1) summary
      cl02808
      Location:20 → 506
      RT_like; Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons, retroviruses, group ...
    Nucleotide Protein
    Heading Accession and Version

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