U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    MET MET proto-oncogene, receptor tyrosine kinase [ Gallus gallus (chicken) ]

    Gene ID: 396134, updated on 10-Oct-2024

    Summary

    Go to the top of the page Help
    Symbol
    METprovided by CGNC
    Full Name
    MET proto-oncogene, receptor tyrosine kinaseprovided by CGNC
    Primary source
    CGNC:7139
    See related
    Ensembl:ENSGALG00010001514
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    C-MET
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See MET in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (25079168..25167189, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (25340024..25428023, complement)

    Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101747342 Neighboring gene capping actin protein of muscle Z-line alpha subunit 2 Neighboring gene uncharacterized LOC121106667 Neighboring gene caveolin 1 Neighboring gene caveolin 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Expression of the hepatocyte growth factor gene during chick limb development. Myokai F, et al. Dev Dyn, 1995 Jan. PMID 7703523
    2. Expression of HGF/SF, HGF1/MSP, and c-met suggests new functions during early chick development. Théry C, et al. Dev Genet, 1995. PMID 7554499
    3. HRAS, EGFR, MET, and RON Genes Are Recurrently Activated by Provirus Insertion in Liver Tumors Induced by the Retrovirus Myeloblastosis-Associated Virus 2. Pecenka V, et al. J Virol, 2017 Oct 15. PMID 28768863, Free PMC Article
    4. Comparative analyses of multi-species sequences from targeted genomic regions. Thomas JW, et al. Nature, 2003 Aug 14. PMID 12917688
    5. A comprehensive collection of chicken cDNAs. Boardman PE, et al. Curr Biol, 2002 Nov 19. PMID 12445392

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phagocytosis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    hepatocyte growth factor receptor
    Names
    proto-oncogene, receptor tyrosine kinase
    tyrosine kinase
    NP_990543.3
    XP_015134695.2
    XP_046762746.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205212.3 → NP_990543.3  hepatocyte growth factor receptor precursor

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000012
      UniProtKB/TrEMBL
      A0A8V0XBU6, A0M8T9
      Related
      ENSGALP00010001947.1, ENSGALT00010003505.1
      Conserved Domains (7) summary
      cd11278
      Location:25 → 516
      Sema_MET; The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
      smart00423
      Location:519 → 561
      PSI; domain found in Plexins, Semaphorins and Integrins
      smart00429
      Location:839 → 935
      IPT; ig-like, plexins, transcription factors
      cd01179
      Location:657 → 741
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:563 → 656
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd05058
      Location:1083 → 1344
      PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
      cl15674
      Location:743 → 838
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      25079168..25167189 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015279209.4 → XP_015134695.2  hepatocyte growth factor receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XBU6, A0M8T9
      Conserved Domains (7) summary
      cd11278
      Location:25 → 516
      Sema_MET; The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
      smart00423
      Location:519 → 561
      PSI; domain found in Plexins, Semaphorins and Integrins
      smart00429
      Location:839 → 935
      IPT; ig-like, plexins, transcription factors
      cd01179
      Location:657 → 741
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:563 → 656
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd05058
      Location:1083 → 1344
      PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
      cl15674
      Location:743 → 838
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      25340024..25428023 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046906790.1 → XP_046762746.1  hepatocyte growth factor receptor isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials