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    EGFR epidermal growth factor receptor [ Microcebus murinus (gray mouse lemur) ]

    Gene ID: 105877217, updated on 11-Apr-2024

    Summary

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    Gene symbol
    EGFR
    Gene description
    epidermal growth factor receptor
    See related
    Ensembl:ENSMICG00000009640
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Microcebus murinus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes; Cheirogaleidae; Microcebus
    Orthologs
    human mouse all
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    Genomic context

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    See EGFR in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    101 current Mmur_3.0 (GCF_000165445.2) 11 NC_033670.1 (106909715..107096243)
    100 previous assembly Mmur_2.0 (GCF_000165445.1) Unplaced Scaffold NW_012196831.1 (37739..224296, complement)

    Chromosome 11 - NC_033670.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105877231 Neighboring gene 52 kDa repressor of the inhibitor of the protein kinase-like Neighboring gene uncharacterized LOC105877218 Neighboring gene RNA-binding protein PNO1 pseudogene Neighboring gene crossover junction endonuclease MUS81 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables epidermal growth factor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables epidermal growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basal plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    epidermal growth factor receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Microcebus murinus Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmur_3.0 Primary Assembly

    Genomic

    1. NC_033670.1 Reference Mmur_3.0 Primary Assembly

      Range
      106909715..107096243
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_012775592.1 → XP_012631046.1  epidermal growth factor receptor isoform X4

      UniProtKB/TrEMBL
      A0A8B7H412, A0A8C5V761
      Related
      ENSMICP00000008784.3, ENSMICT00000009652.3
      Conserved Domains (7) summary
      smart00219
      Location:712 → 967
      TyrKc; Tyrosine kinase, catalytic domain
      smart00261
      Location:552 → 598
      FU; Furin-like repeats
      cd00064
      Location:231 → 274
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      cd05108
      Location:703 → 1015
      PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
      pfam00757
      Location:185 → 335
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:57 → 168
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:505 → 636
      GF_recep_IV; Growth factor receptor domain IV

    2. XM_012775594.2 → XP_012631048.1  epidermal growth factor receptor isoform X5

      See identical proteins and their annotated locations for XP_012631048.1

      UniProtKB/TrEMBL
      A0A8B7XE99, A0A8C5V761
      Conserved Domains (4) summary
      cd05108
      Location:650 → 962
      PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
      pfam00757
      Location:132 → 282
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:4 → 115
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:452 → 583
      GF_recep_IV; Growth factor receptor domain IV

    3. XM_020289952.1 → XP_020145541.1  epidermal growth factor receptor isoform X5

      UniProtKB/TrEMBL
      A0A8B7XE99, A0A8C5V761
      Conserved Domains (4) summary
      cd05108
      Location:650 → 962
      PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
      pfam00757
      Location:132 → 282
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:4 → 115
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:452 → 583
      GF_recep_IV; Growth factor receptor domain IV

    4. XM_020289951.1 → XP_020145540.1  epidermal growth factor receptor isoform X5

      UniProtKB/TrEMBL
      A0A8B7XE99, A0A8C5V761
      Related
      ENSMICP00000037679.2, ENSMICT00000046366.2
      Conserved Domains (4) summary
      cd05108
      Location:650 → 962
      PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
      pfam00757
      Location:132 → 282
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:4 → 115
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:452 → 583
      GF_recep_IV; Growth factor receptor domain IV

    5. XM_012775589.1 → XP_012631043.1  epidermal growth factor receptor isoform X1

      UniProtKB/TrEMBL
      A0A8B7H454, A0A8C5V761
      Related
      ENSMICP00000044521.1, ENSMICT00000067201.1
      Conserved Domains (7) summary
      smart00219
      Location:659 → 914
      TyrKc; Tyrosine kinase, catalytic domain
      smart00261
      Location:499 → 545
      FU; Furin-like repeats
      cd00064
      Location:178 → 221
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      cd05108
      Location:650 → 962
      PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
      pfam00757
      Location:132 → 282
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:4 → 115
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:452 → 583
      GF_recep_IV; Growth factor receptor domain IV

    6. XM_012775590.1 → XP_012631044.1  epidermal growth factor receptor isoform X2

      UniProtKB/TrEMBL
      A0A8B7H697, A0A8C5V761
      Conserved Domains (7) summary
      smart00219
      Location:659 → 914
      TyrKc; Tyrosine kinase, catalytic domain
      smart00261
      Location:499 → 545
      FU; Furin-like repeats
      cd00064
      Location:178 → 221
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      cd05108
      Location:650 → 962
      PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
      pfam00757
      Location:132 → 282
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:4 → 115
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:452 → 583
      GF_recep_IV; Growth factor receptor domain IV

    7. XM_012775591.1 → XP_012631045.1  epidermal growth factor receptor isoform X3

      UniProtKB/TrEMBL
      A0A8B7H415, A0A8C5V761
      Conserved Domains (7) summary
      smart00219
      Location:659 → 914
      TyrKc; Tyrosine kinase, catalytic domain
      smart00261
      Location:499 → 545
      FU; Furin-like repeats
      cd00064
      Location:178 → 221
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      cd05108
      Location:650 → 962
      PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
      pfam00757
      Location:132 → 282
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:4 → 115
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:452 → 583
      GF_recep_IV; Growth factor receptor domain IV
    Nucleotide Protein
    Heading Accession and Version

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