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    uacab uveal autoantigen with coiled-coil domains and ankyrin repeats b [ Danio rerio (zebrafish) ]

    Gene ID: 564040, updated on 2-Nov-2024

    Summary

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    Official Symbol
    uacabprovided by ZNC
    Official Full Name
    uveal autoantigen with coiled-coil domains and ankyrin repeats bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030521-32
    See related
    Ensembl:ENSDARG00000060238 AllianceGenome:ZFIN:ZDB-GENE-030521-32
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj33f05; sb:cb472; wu:fj33f05
    Summary
    Predicted to be involved in intrinsic apoptotic signaling pathway; negative regulation of inflammatory response; and negative regulation of non-canonical NF-kappaB signal transduction. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including gut; hindbrain neural plate; midbrain neural keel; musculature system; and nervous system. Orthologous to human UACA (uveal autoantigen with coiled-coil domains and ankyrin repeats). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See uacab in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (33800631..33868878, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (33529481..33597735, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496098 Neighboring gene TLE family member 3, transcriptional corepressor b Neighboring gene relaxin family peptide receptor 3.3a1 Neighboring gene protein inhibitor of activated STAT, 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Genome wide analysis of 3' UTR sequence elements and proteins regulating mRNA stability during maternal-to-zygotic transition in zebrafish. Vejnar CE, et al. Genome Res, 2019 Jul. PMID 31227602, Free PMC Article
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway in response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of non-canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uveal autoantigen with coiled-coil domains and ankyrin repeats b; uveal autoantigen with coiled-coil domains and ankyrin repeats protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      33800631..33868878 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005168952.5 → XP_005169009.1  uveal autoantigen with coiled-coil domains and ankyrin repeats protein isoform X1

      UniProtKB/TrEMBL
      A0A286Y884, A0A8M2BG92
      Related
      ENSDARP00000143336.1, ENSDART00000178746.2
      Conserved Domains (7) summary
      cl14654
      Location:985 → 1265
      V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
      cd12208
      Location:1247 → 1339
      septicolysin_like; putative septicolysin, cholesterol-dependent cytolysin family and related proteins
      cd00204
      Location:54 → 176
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      TIGR04523
      Location:447 → 1212
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam12796
      Location:61 → 153
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:27 → 77
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:56 → 87
      ANK; ANK repeat [structural motif]

    2. XM_021477874.2 → XP_021333549.1  uveal autoantigen with coiled-coil domains and ankyrin repeats protein isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q8P3, F1QM39
      Related
      ENSDARP00000069215.4, ENSDART00000074729.6
      Conserved Domains (5) summary
      cd00204
      Location:50 → 172
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:52 → 83
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:19 → 73
      Ank_4; Ankyrin repeats (many copies)
      cl25732
      Location:413 → 1296
      SMC_N; RecF/RecN/SMC N terminal domain
      cl27539
      Location:269 → 481
      Peptidase_M23; Peptidase family M23
    Nucleotide Protein Strain
    Heading Accession and Version

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