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    PF3D7_1361400 actin-depolymerizing factor 2 [ Plasmodium falciparum 3D7 ]

    Gene ID: 814286, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_1361400
    Gene description
    actin-depolymerizing factor 2
    Locus tag
    PF3D7_1361400
    See related
    PlasmoDB:PF3D7_1361400; VEuPathDB:PF3D7_1361400
    Gene type
    protein coding
    RNA name
    actin-depolymerizing factor 2
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_1361400 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    2
    Sequence:
    Chromosome: 13; NC_004331.3 (2464135..2464718, complement)

    Chromosome 13 - NC_004331.3Genomic Context describing neighboring genes Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene PH domain-containing protein, putative Neighboring gene Fe-S assembly protein IscX, putative

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_004331.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A mechanism for actin filament severing by malaria parasite actin depolymerizing factor 1 via a low affinity binding interface. Wong W, et al. J Biol Chem, 2014 Feb 14. PMID 24371134, Free PMC Article
    2. Minimal requirements for actin filament disassembly revealed by structural analysis of malaria parasite actin-depolymerizing factor 1. Wong W, et al. Proc Natl Acad Sci U S A, 2011 Jun 14. PMID 21628589, Free PMC Article
    3. A Plasmodium actin-depolymerizing factor that binds exclusively to actin monomers. Schüler H, et al. Mol Biol Cell, 2005 Sep. PMID 15975905, Free PMC Article
    4. Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, et al. Nature, 2002 Oct 3. PMID 12368867
    5. Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, et al. Nature, 2002 Oct 3. PMID 12368864, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. data suggest that a second, low affinity actin-binding site may be universally used by ADF/cofilins for actin filament severing.
      Title: A mechanism for actin filament severing by malaria parasite actin depolymerizing factor 1 via a low affinity binding interface.
    2. Studies indicatet that Plasmodium falciparum contains two members of the actin-depolymerizing factor/cofilin (AC) family of proteins, P. falciparum actin-depolymerizing factor 1 and P. falciparum actin-depolymerizing factor 2.
      Title: Minimal requirements for actin filament disassembly revealed by structural analysis of malaria parasite actin-depolymerizing factor 1.
    3. ADF1 performs vital functions during the pathogenic red blood cell stages of the parasite; recombinant ADF1 interacts with monomeric actin but does not bind to actin polymers.
      Title: A Plasmodium actin-depolymerizing factor that binds exclusively to actin monomers.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    NOT enables actin filament binding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables actin monomer binding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cytoplasmic actin-based contraction involved in cell motility IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    actin-depolymerizing factor 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004331.3 Reference assembly

      Range
      2464135..2464718 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001350289.1 → XP_001350325.1  actin-depolymerizing factor 2 [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001350325.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P86293, Q8ID92
      UniProtKB/TrEMBL
      A0A024V2E2, A0A024VKW2, A0A024WJN7, A0A024X2J3, A0A0L1I7P4, A0A0L7KEH6, W4IAR0, W4IZF3, W7F8Y9, W7FCU6, W7J711, W7KA96
      Conserved Domains (1) summary
      cd11286
      Location:3 → 135
      ADF_cofilin_like; Cofilin, Destrin, and related actin depolymerizing factors
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8ID92.1

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