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    PF3D7_1147800.1 membrane associated erythrocyte binding-like protein [ Plasmodium falciparum 3D7 ]

    Gene ID: 811029, updated on 10-Jul-2024

    Summary

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    Gene symbol
    PF3D7_1147800.1
    Gene description
    membrane associated erythrocyte binding-like protein
    Locus tag
    PF3D7_1147800.1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Old locus tag
    PF3D7_1147800.2
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    Genomic context

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    See PF3D7_1147800.1 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    5
    Sequence:
    Chromosome: 11; NC_037282.1 (1899181..1905942)

    Chromosome 11 - NC_037282.1Genomic Context describing neighboring genes Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene ATP synthase subunit delta, mitochondrial, putative Neighboring gene peroxisome assembly protein 22, putative Neighboring gene serine/threonine protein kinase, putative

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037282.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The transmembrane isoform of Plasmodium falciparum MAEBL is essential for the invasion of Anopheles salivary glands. Saenz FE, et al. PLoS One, 2008 May 28. PMID 18509478, Free PMC Article
    2. Comparative analysis of molecular variation in Plasmodium falciparum and P. reichenowi maebl gene. Verra F, et al. Parassitologia, 2006 Dec. PMID 17688178
    3. Conservation and developmental control of alternative splicing in maebl among malaria parasites. Singh N, et al. J Mol Biol, 2004 Oct 22. PMID 15465047
    4. AMA1 and MAEBL are important for Plasmodium falciparum sporozoite infection of the liver. Yang ASP, et al. Cell Microbiol, 2017 Sep. PMID 28371168
    5. Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, et al. Nature, 2002 Oct 3. PMID 12368864, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study shows that AMA1 and MAEBL are important for P. falciparum sporozoites to perform typical functions necessary for infection of human hepatocytes. These two proteins therefore have important roles during infection at distinct points in the life cycle, including the blood, mosquito, and liver stages.
      Title: AMA1 and MAEBL are important for Plasmodium falciparum sporozoite infection of the liver.
    2. The transmembrane isoform of Plasmodium falciparum MAEBL is essential for the invasion of Anopheles salivary glands
      Title: The transmembrane isoform of Plasmodium falciparum MAEBL is essential for the invasion of Anopheles salivary glands.
    3. MAEBL is the first P. falciparum ligand experimentally determined to be essential for this important step in the life cycle where the vector becomes infectious for transmitting sporozoites to people
      Title: The transmembrane isoform of Plasmodium falciparum MAEBL is essential for the invasion of Anopheles salivary glands.
    4. The M2 domain was sequenced from 3D7 and lab isolates and African samples. No evidence of diversifying or positive selection was found in the pattern of base substitutions.
      Title: Comparative analysis of molecular variation in Plasmodium falciparum and P. reichenowi maebl gene.
    5. mRNA processing and alternative splicing of maebl was developmentally regulated
      Title: Conservation and developmental control of alternative splicing in maebl among malaria parasites.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables host cell surface binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within symbiont entry into host IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in rhoptry IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    membrane associated erythrocyte binding-like protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037282.1 Reference assembly

      Range
      1899181..1905942
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001348117.1 → XP_001348153.1  membrane associated erythrocyte binding-like protein [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001348153.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0L7KA77, Q8IHP3, Q8T5C7
      Conserved Domains (1) summary
      PTZ00121
      Location:1 → 2055
      PTZ00121; MAEBL; Provisional

    2. XM_024473334.1 → XP_024329139.1  membrane associated erythrocyte binding-like protein [Plasmodium falciparum 3D7]

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A144A3C7, Q7K5Q5, Q7K5Q6
      Conserved Domains (1) summary
      PTZ00121
      Location:1 → 1991
      PTZ00121; MAEBL; Provisional
    Nucleotide Protein
    Heading Accession and Version

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