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    PF3D7_1235600 serine hydroxymethyltransferase [ Plasmodium falciparum 3D7 ]

    Gene ID: 811396, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_1235600
    Gene description
    serine hydroxymethyltransferase
    Locus tag
    PF3D7_1235600
    See related
    PlasmoDB:PF3D7_1235600; VEuPathDB:PF3D7_1235600
    Gene type
    protein coding
    RNA name
    serine hydroxymethyltransferase
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_1235600 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    3
    Sequence:
    Chromosome: 12; NC_037284.1 (1484306..1485911)

    Chromosome 12 - NC_037284.1Genomic Context describing neighboring genes Neighboring gene tetQ family GTPase, putative Neighboring gene mRNA methyltransferase, putative Neighboring gene ATP synthase subunit beta, mitochondrial Neighboring gene conserved Plasmodium protein, unknown function

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037284.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of Plasmodium falciparum serine hydroxymethyltransferase-A potential antimalarial target. Maenpuen S, et al. Mol Biochem Parasitol, 2009 Nov. PMID 19591881
    2. Characterization of three genes encoding enzymes of the folate biosynthetic pathway in Plasmodium falciparum. Lee CS, et al. Parasitology, 2001 Jan. PMID 11197757
    3. Vitamin B6-dependent enzymes in the human malaria parasite Plasmodium falciparum: a druggable target? Kronenberger T, et al. Biomed Res Int, 2014. PMID 24524072, Free PMC Article
    4. Dynamic subcellular localization of isoforms of the folate pathway enzyme serine hydroxymethyltransferase (SHMT) through the erythrocytic cycle of Plasmodium falciparum. Read M, et al. Malar J, 2010 Dec 3. PMID 21129192, Free PMC Article
    5. Catalytic and ligand-binding characteristics of Plasmodium falciparum serine hydroxymethyltransferase. Pang CK, et al. Mol Biochem Parasitol, 2009 Nov. PMID 19591883, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables glycine hydroxymethyltransferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within D-serine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within one-carbon metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apicoplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine hydroxymethyltransferase
    XP_001350750.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037284.1 Reference assembly

      Range
      1484306..1485911
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001350714.1 → XP_001350750.1  serine hydroxymethyltransferase [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001350750.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q8I566
      UniProtKB/TrEMBL
      A0A024V4I3, A0A024W439, A0A024X4Z7, A0A0L0CSS5, A0A0L1I2L6, A0A0L7KB02, A0A0L7LVN3, A0A2I0BYZ6, Q9U638, W4IEG3, W4J1G6, W7FBK8, W7J8G0
      Conserved Domains (1) summary
      PTZ00094
      Location:1 → 441
      PTZ00094; serine hydroxymethyltransferase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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