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    PAEP progestagen associated endometrial protein [ Homo sapiens (human) ]

    Gene ID: 5047, updated on 9-Dec-2024

    Summary

    Official Symbol
    PAEPprovided by HGNC
    Official Full Name
    progestagen associated endometrial proteinprovided by HGNC
    Primary source
    HGNC:HGNC:8573
    See related
    Ensembl:ENSG00000122133 MIM:173310; AllianceGenome:HGNC:8573
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GD; GdA; GdF; GdS; PEP; PAEG; PP14; ZIF-1
    Summary
    This gene is a member of the kernel lipocalin superfamily whose members share relatively low sequence similarity but have highly conserved exon/intron structure and three-dimensional protein folding. Most lipocalins are clustered on the long arm of chromosome 9. The encoded glycoprotein has been previously referred to as pregnancy-associated endometrial alpha-2-globulin, placental protein 14, and glycodelin, but has been officially named progestagen-associated endometrial protein. Three distinct forms, with identical protein backbones but different glycosylation profiles, are found in amniotic fluid, follicular fluid and seminal plasma of the reproductive system. These glycoproteins have distinct and essential roles in regulating a uterine environment suitable for pregnancy and in the timing and occurrence of the appropriate sequence of events in the fertilization process. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
    Expression
    Restricted expression toward endometrium (RPKM 125.9) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PAEP in Genome Data Viewer
    Location:
    9q34.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (135561756..135566955)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (147789564..147794795)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (138453602..138458801)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene odorant binding protein 2A Neighboring gene uncharacterized LOC107987040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:138457239-138457870 Neighboring gene long intergenic non-protein coding RNA 1502 Neighboring gene uncharacterized LOC105376316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:138479168-138479918 Neighboring gene progestagen associated endometrial protein pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env 3-hydroxyphthalic anhydride (3HP) modified glycodelin GdA and GdS proteins inhibit HIV-1 gp120-CD4 binding and induce anti-HIV activity PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    glycodelin
    Names
    PEG
    PP14 protein (placental protein 14)
    alpha uterine protein
    glycodelin-A
    glycodelin-F
    glycodelin-S
    placental protein 14
    pregnancy-associated endometrial alpha-2 globulin
    progestagen-associated endometrial protein (placental protein 14, pregnancy-associated endometrial a
    progesterone-associated endometrial protein
    zona-binding inhibitory factor-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001018048.2NP_001018058.1  glycodelin isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate, in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
      Source sequence(s)
      AK304657, AL050169, AL354761, DC421713
      UniProtKB/TrEMBL
      B4E3C0
      Conserved Domains (1) summary
      pfam00061
      Location:32153
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
    2. NM_001018049.3NP_001018059.1  glycodelin isoform 1 precursor

      See identical proteins and their annotated locations for NP_001018059.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK309983, AL050169, AL354761, BC113728, M61886
      Consensus CDS
      CCDS35173.1
      UniProtKB/Swiss-Prot
      P09466, Q5T6T1, Q9UG92
      UniProtKB/TrEMBL
      B2R4F9
      Related
      ENSP00000277508.5, ENST00000277508.9
      Conserved Domains (1) summary
      pfam00061
      Location:34175
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
    3. NM_002571.4NP_002562.2  glycodelin isoform 1 precursor

      See identical proteins and their annotated locations for NP_002562.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate, in-frame splice site in the 3' UTR, compared to variant 1. It encodes the same protein as variant 1.
      Source sequence(s)
      AK311813, AL050169, AL354761, J04129
      Consensus CDS
      CCDS35173.1
      UniProtKB/Swiss-Prot
      P09466, Q5T6T1, Q9UG92
      UniProtKB/TrEMBL
      B2R4F9
      Related
      ENSP00000417898.1, ENST00000479141.6
      Conserved Domains (1) summary
      pfam00061
      Location:34175
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      135561756..135566955
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011518746.3XP_011517048.1  glycodelin isoform X1

      See identical proteins and their annotated locations for XP_011517048.1

      Conserved Domains (1) summary
      pfam00061
      Location:34199
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
    2. XM_011518745.3XP_011517047.1  glycodelin isoform X1

      See identical proteins and their annotated locations for XP_011517047.1

      Conserved Domains (1) summary
      pfam00061
      Location:34199
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
    3. XM_011518752.3XP_011517054.1  glycodelin isoform X5

      See identical proteins and their annotated locations for XP_011517054.1

      UniProtKB/TrEMBL
      A6XNE0
      Related
      ENSP00000484659.1, ENST00000611414.4
      Conserved Domains (1) summary
      pfam00061
      Location:34104
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
    4. XM_011518748.2XP_011517050.1  glycodelin isoform X2

      UniProtKB/TrEMBL
      B4E3C0
      Conserved Domains (1) summary
      pfam00061
      Location:32177
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
    5. XM_011518751.2XP_011517053.1  glycodelin isoform X4

      See identical proteins and their annotated locations for XP_011517053.1

      UniProtKB/TrEMBL
      B4E3C0
      Conserved Domains (1) summary
      pfam00061
      Location:32153
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
    6. XM_017014782.3XP_016870271.1  glycodelin isoform X6

    7. XM_011518747.2XP_011517049.1  glycodelin isoform X1

      See identical proteins and their annotated locations for XP_011517049.1

      Conserved Domains (1) summary
      pfam00061
      Location:34199
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
    8. XM_011518749.2XP_011517051.1  glycodelin isoform X3

      See identical proteins and their annotated locations for XP_011517051.1

      UniProtKB/Swiss-Prot
      P09466, Q5T6T1, Q9UG92
      UniProtKB/TrEMBL
      B2R4F9
      Related
      ENSP00000360831.1, ENST00000371766.6
      Conserved Domains (1) summary
      pfam00061
      Location:34175
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
    9. XM_017014783.2XP_016870272.1  glycodelin isoform X7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      147789564..147794795
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)