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    F8 coagulation factor VIII [ Pongo abelii (Sumatran orangutan) ]

    Gene ID: 100174452, updated on 6-Jun-2024

    Summary

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    Gene symbol
    F8
    Gene description
    coagulation factor VIII
    Locus tag
    CR201_G0049972
    See related
    Ensembl:ENSPPYG00000020895
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pongo abelii
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: X
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPonAbe1-v2.0_pri (GCF_028885655.2) X NC_072008.2 (161333890..161553381, complement)
    RS_2023_04 previous assembly NHGRI_mPonAbe1-v1.1-hic.freeze_pri (GCF_028885655.1) X NC_072008.1 (161333917..161557019, complement)

    Chromosome X - NC_072008.2Genomic Context describing neighboring genes Neighboring gene non-histone chromosomal protein HMG-14-like Neighboring gene small integral membrane protein 9 Neighboring gene histone H2A-Bbd type 2/3 Neighboring gene coagulation factor VIII associated 1 Neighboring gene FUN14 domain containing 2 Neighboring gene mature T cell proliferation 1 Neighboring gene C-X9-C motif containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp459D2216

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    coagulation factor VIII
    Names
    coagulation factor VIII, procoagulant component

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_028885655.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

    Genomic

    1. NC_072008.2 Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

      Range
      161333890..161553381 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024240562.3 → XP_024096330.1  coagulation factor VIII isoform X2

      UniProtKB/TrEMBL
      A0A2J8RMD1, A0A8I5YK92, Q5RAM1
      Related
      ENSPPYP00000028171.1
      Conserved Domains (2) summary
      cd00057
      Location:60 → 209
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cl25480
      Location:4 → 52
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    2. XM_054545278.2 → XP_054401253.1  coagulation factor VIII isoform X1

      UniProtKB/TrEMBL
      Q5RAM1

    3. XM_024240561.3 → XP_024096329.1  coagulation factor VIII isoform X3

      UniProtKB/TrEMBL
      A0A2J8RM48, H2PXB0
      Related
      ENSPPYP00000023391.3
      Conserved Domains (7) summary
      cd00057
      Location:2195 → 2344
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd04227
      Location:399 → 575
      CuRO_3_FVIII_like; The third cupredoxin domain of coagulation factor VIII and similar proteins
      cd04228
      Location:1714 → 1880
      CuRO_5_FVIII_like; The fifth cupredoxin domain of coagulation factor VIII and similar proteins
      cd11015
      Location:211 → 345
      CuRO_2_FVIII_like; The second cupredoxin domain of coagulation factor VIII and similar proteins
      cd11016
      Location:588 → 730
      CuRO_4_FVIII_like; The fourth cupredoxin domain of coagulation factor VIII and similar proteins
      cd11018
      Location:1892 → 2035
      CuRO_6_FVIII_like; The sixth cupredoxin domain of coagulation factor VIII and similar proteins
      cd14452
      Location:22 → 201
      CuRO_1_FVIII_like; The first cupredoxin domain of coagulation factor VIII and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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