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    arhgap29b Rho GTPase activating protein 29b [ Danio rerio (zebrafish) ]

    Gene ID: 378998, updated on 2-Nov-2024

    Summary

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    Official Symbol
    arhgap29bprovided by ZNC
    Official Full Name
    Rho GTPase activating protein 29bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-031010-44
    See related
    Ensembl:ENSDARG00000017748 AllianceGenome:ZFIN:ZDB-GENE-031010-44
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    arhgap29; sb:cb905; zgc:63950
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of small GTPase mediated signal transduction. Predicted to act upstream of or within signal transduction. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; pectoral fin bud; pectoral fin musculature; periderm; and tail bud. Orthologous to human ARHGAP29 (Rho GTPase activating protein 29). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See arhgap29b in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (15128398..15197920)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (15459542..15529330)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene coagulation factor IIIb Neighboring gene ATP-binding cassette, sub-family D (ALD), member 3b Neighboring gene ATP-binding cassette, sub-family A (ABC1), member 4b Neighboring gene trans-2,3-enoyl-CoA reductase-like 2b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolutionary emergence of the rac3b/rfng/sgca regulatory cluster refined mechanisms for hindbrain boundaries formation. Letelier J, et al. Proc Natl Acad Sci U S A, 2018 Apr 17. PMID 29610331, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of small GTPase mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 29
    Names
    Rho GTPase activating protein 29
    rho-type GTPase-activating protein 29

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200111.2 → NP_956405.2  rho GTPase-activating protein 29

      Status: VALIDATED

      Source sequence(s)
      CR450809
      UniProtKB/Swiss-Prot
      Q6PCS4
      Related
      ENSDARP00000115452.1, ENSDART00000141921.3
      Conserved Domains (3) summary
      smart00109
      Location:677 → 723
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd04409
      Location:735 → 945
      RhoGAP_PARG1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts with Rap2, also ...
      cl12013
      Location:253 → 466
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      15128398..15197920
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005163312.5 → XP_005163369.1  rho GTPase-activating protein 29 isoform X1

      UniProtKB/Swiss-Prot
      Q6PCS4
      UniProtKB/TrEMBL
      A0A8M2BAB9
      Conserved Domains (3) summary
      smart00109
      Location:677 → 723
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd04409
      Location:735 → 945
      RhoGAP_PARG1; RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts ...
      cl12013
      Location:253 → 466
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. XM_005163314.5 → XP_005163371.1  rho GTPase-activating protein 29 isoform X2

      UniProtKB/Swiss-Prot
      Q6PCS4
      UniProtKB/TrEMBL
      A0A8M2BAG0
      Conserved Domains (3) summary
      smart00109
      Location:671 → 717
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd04409
      Location:729 → 939
      RhoGAP_PARG1; RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts ...
      cl12013
      Location:247 → 460
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    3. XM_005163315.5 → XP_005163372.1  rho GTPase-activating protein 29 isoform X3

      UniProtKB/Swiss-Prot
      Q6PCS4
      UniProtKB/TrEMBL
      A0A8M2BAH9
      Conserved Domains (3) summary
      smart00109
      Location:501 → 547
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd04409
      Location:559 → 769
      RhoGAP_PARG1; RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts ...
      cl12013
      Location:77 → 290
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PCS4.1 GenPept UniProtKB/Swiss-Prot:Q6PCS4

    Gene LinkOut

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