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    HHV8GK18_gp78 ORF69 [ Human gammaherpesvirus 8 ]

    Gene ID: 4961444, updated on 18-Aug-2023

    Summary

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    Gene symbol
    HHV8GK18_gp78
    Gene description
    ORF69
    Locus tag
    HHV8GK18_gp78
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Human gammaherpesvirus 8 (strain: GK18, type: P, common: Kaposi's sarcoma-associated herpesvirus, acronym: HHV-8, acronym: KSHV, nat-host: Homo sapiens)
    Lineage
    Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus
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    Genomic context

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    Sequence:
    NC_009333.1 (116544..117514)

    NC_009333.1Genomic Context describing neighboring genes Neighboring gene ORF58 Neighboring gene ORF60 Neighboring gene ORF61 Neighboring gene ORF59 Neighboring gene ORF62 Neighboring gene ORF63 Neighboring gene ORF64 Neighboring gene ORF67A Neighboring gene ORF65 Neighboring gene ORF66 Neighboring gene ORF67 Neighboring gene ORF68 Neighboring gene K12 Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009333.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interactions of the Kaposi's Sarcoma-associated herpesvirus nuclear egress complex: ORF69 is a potent factor for remodeling cellular membranes. Luitweiler EM, et al. J Virol, 2013 Apr. PMID 23365436, Free PMC Article
    2. Identification and characterization of the product encoded by ORF69 of Kaposi's sarcoma-associated herpesvirus. Santarelli R, et al. J Virol, 2008 May. PMID 18305046, Free PMC Article
    3. Reconstitution of the Kaposi's sarcoma-associated herpesvirus nuclear egress complex and formation of nuclear membrane vesicles by coexpression of ORF67 and ORF69 gene products. Desai PJ, et al. J Virol, 2012 Jan. PMID 22013050, Free PMC Article
    4. Identification of a spliced gene from Kaposi's sarcoma-associated herpesvirus encoding a protein with similarities to latent membrane proteins 1 and 2A of Epstein-Barr virus. Glenn M, et al. J Virol, 1999 Aug. PMID 10400794, Free PMC Article
    5. Kaposi's sarcoma-associated herpesvirus immune modulation: an overview. Rezaee SAR, et al. J Gen Virol, 2006 Jul. PMID 16760382

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ORF69 is the factor required to remodel cellular membranes into circular-virion-size vesicles.
      Title: Interactions of the Kaposi's Sarcoma-associated herpesvirus nuclear egress complex: ORF69 is a potent factor for remodeling cellular membranes.
    2. ORF67 and ORF69 proteins form a complex at the nuclear membrane derived vesicles.
      Title: Reconstitution of the Kaposi's sarcoma-associated herpesvirus nuclear egress complex and formation of nuclear membrane vesicles by coexpression of ORF67 and ORF69 gene products.
    3. shares many similarities with EBV homolog BFLF2; Following ectopic expression in KSHV-negative cells, the protein never associated with the nuclear membrane, suggesting that p33 needs to interact with additional viral proteins to reach the nuclear rim.
      Title: Identification and characterization of the product encoded by ORF69 of Kaposi's sarcoma-associated herpesvirus.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    regulatory

    • Loc: 117509-117514 regulatory_class = polyA_signal_sequence

    General protein information

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    Preferred Names
    ORF69
    YP_001129427.1
    • herpesvirus core gene UL31 family

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_009333.1 Reference assembly

      Range
      116544..117514
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_001129427.1 ORF69 [Human gammaherpesvirus 8]

      See identical proteins and their annotated locations for YP_001129427.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      F5H982
      UniProtKB/TrEMBL
      A0A7D5YR20, O40945, Q77Q39
      Conserved Domains (1) summary
      pfam02718
      Location:38 → 300
      Herpes_UL31; Herpesvirus UL31-like protein
    Nucleotide Protein
    Heading Accession and Version

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