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    OR11A1 olfactory receptor family 11 subfamily A member 1 [ Homo sapiens (human) ]

    Gene ID: 26531, updated on 2-Nov-2024

    Summary

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    Official Symbol
    OR11A1provided by HGNC
    Official Full Name
    olfactory receptor family 11 subfamily A member 1provided by HGNC
    Primary source
    HGNC:HGNC:8176
    See related
    Ensembl:ENSG00000204694 AllianceGenome:HGNC:8176
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    6M1-18; OR11A2; hs6M1-18; dJ994E9.6
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
    Orthologs
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    Genomic context

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    See OR11A1 in Genome Data Viewer
    Location:
    6p22.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (29425504..29457071, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (29300160..29331729, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (29393281..29424848, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 12 subfamily D member 2 Neighboring gene olfactory receptor family 12 subfamily D member 1 (gene/pseudogene) Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:29408251-29408751 Neighboring gene uncharacterized LOC105379641 Neighboring gene olfactory receptor family 10 subfamily C member 1 Neighboring gene NANOG hESC enhancer GRCh37_chr6:29415417-29415953 Neighboring gene olfactory receptor family 2 subfamily H member 1 Neighboring gene ubiquitin D pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Complex transcription and splicing of odorant receptor genes. Volz A, et al. J Biol Chem, 2003 May 30. PMID 12637542
    2. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. Barcellos LF, et al. PLoS Genet, 2009 Oct. PMID 19851445, Free PMC Article
    3. The human olfactory receptor gene family. Malnic B, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983052, Free PMC Article
    4. The DNA sequence and analysis of human chromosome 6. Mungall AJ, et al. Nature, 2003 Oct 23. PMID 14574404
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables olfactory receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    olfactory receptor 11A1
    Names
    olfactory receptor 11A2
    olfactory receptor OR6-30
    olfactory receptor, family 11, subfamily A, member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034047.2 RefSeqGene

      Range
      5000..36567
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001394828.1 → NP_001381757.1  olfactory receptor 11A1

      Status: VALIDATED

      Source sequence(s)
      AJ459854, AL645927
      Consensus CDS
      CCDS34363.1
      UniProtKB/Swiss-Prot
      A2BF33, A6NFQ3, B0S7T2, Q5ST16, Q9GZK7, Q9GZK8
      UniProtKB/TrEMBL
      A0A024RCH9, A0A1U9X883, A0A1U9X8A9
      Related
      ENSP00000366354.1, ENST00000377149.5
      Conserved Domains (1) summary
      cd15911
      Location:27 → 295
      7tmA_OR11A-like; olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001394829.1 → NP_001381758.1  olfactory receptor 11A1

      Status: VALIDATED

      Source sequence(s)
      AJ459855, AL645927
      Consensus CDS
      CCDS34363.1
      UniProtKB/Swiss-Prot
      A2BF33, A6NFQ3, B0S7T2, Q5ST16, Q9GZK7, Q9GZK8
      UniProtKB/TrEMBL
      A0A024RCH9, A0A1U9X883, A0A1U9X8A9
      Related
      ENSP00000366353.1, ENST00000377148.5
      Conserved Domains (1) summary
      cd15911
      Location:27 → 295
      7tmA_OR11A-like; olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. NM_013937.4 → NP_039225.1  olfactory receptor 11A1

      See identical proteins and their annotated locations for NP_039225.1

      Status: VALIDATED

      Source sequence(s)
      AL645927
      Consensus CDS
      CCDS34363.1
      UniProtKB/Swiss-Prot
      A2BF33, A6NFQ3, B0S7T2, Q5ST16, Q9GZK7, Q9GZK8
      UniProtKB/TrEMBL
      A0A024RCH9, A0A1U9X883, A0A1U9X8A9
      Related
      ENSP00000493093.1, ENST00000641152.2
      Conserved Domains (1) summary
      cd15911
      Location:27 → 295
      7tmA_OR11A-like; olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      29425504..29457071 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_167244.2 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      691169..722731 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      911953..943524 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

      Range
      691032..722594 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

      Range
      690640..722195 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

      Range
      690872..722445 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

      Range
      690974..722536 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_7

    Genomic

    1. NT_167249.2 Reference GRCh38.p14 ALT_REF_LOCI_7

      Range
      734515..766084 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      29300160..29331729 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9GZK7.1 GenPept UniProtKB/Swiss-Prot:Q9GZK7

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