pcdh2ab5 protocadherin 2 alpha b 5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pcdh2ab5provided by ZNC
Official Full Name: protocadherin 2 alpha b 5provided by ZNC
Primary source: ZFIN:ZDB-GENE-041118-4
See related: Ensembl:ENSDARG00000090348 AllianceGenome:ZFIN:ZDB-GENE-041118-4
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zcnrv5; pcdh2a29
Summary: Predicted to enable calcium ion binding activity. Predicted to be involved in cell adhesion. Predicted to act upstream of or within homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to several human genes including PCDHA1 (protocadherin alpha 1); PCDHA10 (protocadherin alpha 10); and PCDHA12 (protocadherin alpha 12). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

Location:: chromosome: 14

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (2123123..2209742, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (2204772..2291391, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protocadherin 2 alpha b 5

Names: protocadherin 2 alpha 29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008483.2 → NP_001008483.2 protocadherin 2 alpha b 5 precursor

Status: VALIDATED

Source sequence(s)

CR847851, CT573264

UniProtKB/TrEMBL

Q60I72

Related

ENSDARP00000054888.5, ENSDART00000054889.6

Conserved Domains (4) summary

cd11304
Location:458 → 559

Cadherin_repeat; Cadherin tandem repeat domain

pfam08266
Location:29 → 111

Cadherin_2; Cadherin-like

pfam15974
Location:796 → 913

Cadherin_tail; Cadherin C-terminal cytoplasmic tail, catenin-binding region

pfam16492
Location:687 → 759

Cadherin_C_2; Cadherin cytoplasmic C-terminal