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    Phactr4 phosphatase and actin regulator 4 [ Mus musculus (house mouse) ]

    Gene ID: 100169, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Phactr4provided by MGI
    Official Full Name
    phosphatase and actin regulator 4provided by MGI
    Primary source
    MGI:MGI:2140327
    See related
    Ensembl:ENSMUSG00000066043 AllianceGenome:MGI:2140327
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA4120; 3110001B12Rik; C330013F19Rik
    Summary
    Enables actin binding activity; protein phosphatase 1 binding activity; and protein phosphatase activator activity. Involved in several processes, including enteric nervous system development; morphogenesis of embryonic epithelium; and negative regulation of integrin-mediated signaling pathway. Located in lamellipodium. Is expressed in several structures, including 1st branchial arch mandibular component; central nervous system; facial prominence; and retina. Orthologous to human PHACTR4 (phosphatase and actin regulator 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 6.0), limb E14.5 (RPKM 5.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Phactr4 in Genome Data Viewer
    Location:
    4 D2.3; 4 65.24 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (132083233..132149765, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (132355922..132422446, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element for Atpif1, Phactr4, Ptpru, Rcc1 and Snhg3 Neighboring gene small nucleolar RNA, H/ACA box 73b Neighboring gene small nucleolar RNA, H/ACA box 73a Neighboring gene small nucleolar RNA host gene 3 Neighboring gene predicted gene, 23055 Neighboring gene STARR-seq mESC enhancer starr_11566 Neighboring gene STARR-positive B cell enhancer ABC_E9596 Neighboring gene mediator complex subunit 18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Actin-regulated feedback loop based on Phactr4, PP1 and cofilin maintains the actin monomer pool. Huet G, et al. J Cell Sci, 2013 Jan 15. PMID 23203801
    2. A role for natural regulatory T cells in the pathogenesis of experimental cerebral malaria. Amante FH, et al. Am J Pathol, 2007 Aug. PMID 17600128, Free PMC Article
    3. Estrogen receptor beta increases clear cell renal cell carcinoma stem cell phenotype via altering the circPHACTR4/miR-34b-5p/c-Myc signaling. Wang Y, et al. FASEB J, 2022 Feb. PMID 35061326
    4. Spatial arrangement of an RNA zipcode identifies mRNAs under post-transcriptional control. Patel VL, et al. Genes Dev, 2012 Jan 1. PMID 22215810, Free PMC Article
    5. Phosphatase and actin regulator 4 is associated with intermediate filaments in adult neural stem cells and their progenitor astrocytes. Cho HM, et al. Histochem Cell Biol, 2014 Oct. PMID 24748504

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Estrogen receptor beta increases clear cell renal cell carcinoma stem cell phenotype via altering the circPHACTR4/miR-34b-5p/c-Myc signaling.
      Title: Estrogen receptor beta increases clear cell renal cell carcinoma stem cell phenotype via altering the circPHACTR4/miR-34b-5p/c-Myc signaling.
    2. The Phactr4 forms functional associations with intermediate filament networks in adult neural stem cells.
      Title: Phosphatase and actin regulator 4 is associated with intermediate filaments in adult neural stem cells and their progenitor astrocytes.
    3. Data discloses the central role of Phactr4 in a feedback loop, where actin monomers regulate their own number via the activation of a key regulator of actin dynamics.
      Title: Actin-regulated feedback loop based on Phactr4, PP1 and cofilin maintains the actin monomer pool.
    4. This study demonistrated that the mRNA expression of phactr4 was progressively increased in the injury penumbra.
      Title: Different expression patterns of Phactr family members in normal and injured mouse brain.
    5. hactr4 negatively regulates integrin signaling through the RHO/ROCK pathway and coordinates protein phosphatase 1 (PP1) with cofilin activity to regulate cytoskeletal dynamics
      Title: Phactr4 regulates directional migration of enteric neural crest through PP1, integrin signaling, and cofilin activity.
    6. Phactr4 is critical for the spatially and temporally regulated transition in proliferation through differential regulation of PP1 and the cell cycle during neurulation and eye development
      Title: Phactr4 regulates neural tube and optic fissure closure by controlling PP1-, Rb-, and E2F1-regulated cell-cycle progression.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ13171, KIAA4120

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein phosphatase 1 binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein phosphatase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein phosphatase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in closure of optic fissure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in enteric nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of integrin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neural crest cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neural crest cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neural tube closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of catalytic activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphatase and actin regulator 4
    Names
    humdy
    protein Humpty dumpty

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161797.2 → NP_001155269.1  phosphatase and actin regulator 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL805897
      Consensus CDS
      CCDS51318.1
      UniProtKB/Swiss-Prot
      Q501J7
      Related
      ENSMUSP00000081185.6, ENSMUST00000084170.12
      Conserved Domains (1) summary
      smart00707
      Location:549 → 573
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2

    2. NM_175306.5 → NP_780515.2  phosphatase and actin regulator 4 isoform 1

      See identical proteins and their annotated locations for NP_780515.2

      Status: VALIDATED

      Source sequence(s)
      AL805897
      Consensus CDS
      CCDS18724.1
      UniProtKB/Swiss-Prot
      A2ALF7, A2ALG0, F6QNZ3, Q501J7, Q5DTM4, Q6DI97, Q8C7U9
      Related
      ENSMUSP00000099628.4, ENSMUST00000102568.10
      Conserved Domains (2) summary
      smart00707
      Location:576 → 600
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:64 → 86
      RPEL; RPEL repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      132083233..132149765 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163538.1 → XP_036019431.1  phosphatase and actin regulator 4 isoform X3

      Conserved Domains (1) summary
      smart00707
      Location:491 → 515
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2

    2. XM_006538456.5 → XP_006538519.1  phosphatase and actin regulator 4 isoform X1

      UniProtKB/Swiss-Prot
      Q501J7
      Related
      ENSMUSP00000081270.5, ENSMUST00000084249.11
      Conserved Domains (2) summary
      smart00707
      Location:586 → 610
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:75 → 97
      RPEL; RPEL repeat

    3. XM_006538457.5 → XP_006538520.1  phosphatase and actin regulator 4 isoform X2

      Conserved Domains (1) summary
      smart00707
      Location:559 → 583
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2

    4. XM_011250172.2 → XP_011248474.1  phosphatase and actin regulator 4 isoform X5

      Conserved Domains (1) summary
      smart00707
      Location:302 → 326
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2

    5. XM_036163539.1 → XP_036019432.1  phosphatase and actin regulator 4 isoform X4

      Conserved Domains (1) summary
      pfam02755
      Location:75 → 97
      RPEL; RPEL repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q501J7.2 GenPept UniProtKB/Swiss-Prot:Q501J7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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